Drug & supplement interaction

Khat + Isopropamide, Prochlorperazine

Isopropamide, Prochlorperazine brand name: Combid.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Khat has a moderate interaction with Isopropamide, Prochlorperazine. Khat may affect response to antipsychotic treatment.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Khat and Isopropamide, Prochlorperazine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIPSYCHOTIC DRUGS

Why this applies to Isopropamide, Prochlorperazine

Isopropamide, Prochlorperazine falls under ANTIPSYCHOTIC DRUGS — the group Khat interacts with.

Khat may affect response to antipsychotic treatment. In a large retrospective study of adults with newly diagnosed schizophrenia, chewing khat was associated with a decreased retention rate with the initial antipsychotic agent when compared with non-chewers, and lack of efficacy was the most commonly reported reason for switching antipsychotic agents among khat users. Until more is known, avoid khat in patients taking antipsychotic agents.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Combid is a combination product, and the part doing the heavy lifting here is prochlorperazine, an antipsychotic that calms overactive dopamine signaling in the brain (it's also used for nausea). Khat works in the opposite direction. Its stimulant compounds (cathinone and cathine, which act a lot like amphetamine) boost dopamine and norepinephrine release. So khat can essentially push against what prochlorperazine is trying to do.

In a large study of people newly treated for schizophrenia, khat chewers were more likely to switch medications because the drug just wasn't working as well. In plain terms, khat may blunt the benefit you're getting. Setting aside that khat is illegal in the U.S. and risky on its own, please don't combine these without talking to your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hakami T, Mahmoud M, Mohammed B, El-Setouhy M. Effects of khat use on response to antipsychotic medications in patients with newly diagnosed schizophrenia: a retrospective study. East Mediterr Health J 2021;27(4):353-360. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Khat Also Interacts With Other Medications

Khat has 4 major, 400 moderate known drug interactions in our database — the Isopropamide, Prochlorperazine one above is one of them. If you take anything else, check it against the full list below.

Major 4 Moderate 400 No known interaction 2,426 (incl. Isopropamide, Prochlorperazine)
Taking anything else?

Check Another of Your Medications Against Khat

Covers the 2,830 medications we’ve checked against Khat. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Isopropamide, Prochlorperazine

This page covers Khat only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isopropamide, Prochlorperazine page lists 96 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).

By severity: 5 major · 67 moderate · 24 minor.

From our pharmacist’s overview on the Isopropamide, Prochlorperazine page

“Combid combines isopropamide, which quiets an overactive gut, with prochlorperazine, a phenothiazine used for nausea, and its interaction list warrants genuine care rather than a quick skim. Five of the 96 supplement ingredients on file carry a major rating.”

Reviewed by 2 · Jul 18, 2026

Open the Isopropamide, Prochlorperazine interaction page

How much people look this up

Where Khat and Isopropamide, Prochlorperazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Khat
Top half

#392 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isopropamide, Prochlorperazine
Steady interest

#1,734 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Khat

What is Khat?

Khat
  • Stimulant for energy and alertness
  • Euphoria and mood elevation
  • Reducing fatigue
  • Appetite suppression
  • Social and traditional ceremonies

Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problems, mental health effects, and dependence. It is a controlled substance and illegal in the United States and many other countries, so it should not be used.

Read the full Khat monograph & all interactions
Keep checking

Other Drugs & Khat

Browse every other medication we’ve checked against Khat — both the ones with a known interaction and the ones without. Select any drug for the full detail.

4Major
400Moderate
0Minor
2,425No known interaction
4 Major 400 Moderate 2,425 No interaction
Major

4 interactions

Moderate

400 interactions

Showing 60 of 400 moderate interactions — see all 400 on the Khat page.

No interaction 2,425 drugs checked — show the list

We also checked Khat against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,425 medications checked with no known interaction — see the full Khat list.

See the full Khat interactions page
See every supplement checked against Isopropamide, Prochlorperazine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Khat monograph › Uses, safety, and every drug interaction in one place Isopropamide, Prochlorperazine supplement interactions › Every supplement checked against Isopropamide, Prochlorperazine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Khat and Isopropamide, Prochlorperazine Together: Common Questions

Can you take Khat with Isopropamide, Prochlorperazine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Khat and Isopropamide, Prochlorperazine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Isopropamide, Prochlorperazine and Khat?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.