Drug & supplement interaction

Panax Notoginseng + Irbesartan

Irbesartan brand names: Avapro, Aprovel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Panax Notoginseng and Irbesartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Panax Notoginseng and Irbesartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Irbesartan and Panax Notoginseng in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Panax Notoginseng safety at a glance

Panax Notoginseng overall Use caution May be tolerated short-term by healthy adults, but quality human safety data are limited.
Pregnancy Likely Unsafe When used orally. Ginsenoside Rb1, an active constituent of Panax notoginseng, has teratogenic effects in animal models. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Ginsenoside Rb1, an active constituent of Panax notoginseng, has teratogenic effects in animal models. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Irbesartan and Panax Notoginseng? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Irbesartan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Irbesartan is filed under 4 classifications — including angiotensin receptor blockers (arbs), cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. Panax Notoginseng has documented interactions with 4 drug classes — the most serious being aspirin (moderate), caffeine (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Irbesartan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Panax Notoginseng Does Interact With Other Medications

Panax Notoginseng has 207 moderate known drug interactions in our database — Irbesartan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Irbesartan)
Taking anything else?

Check Another of Your Medications Against Panax Notoginseng

Covers the 2,830 medications we’ve checked against Panax Notoginseng. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Panax Notoginseng and Irbesartan May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Swelling Additional detail

    Panax Notoginseng

    “Intravenously, Panax notoginseng saponins have been associated with five cases of pustular drug eruption due to acute generalized exanthematous pustulosis. The skin eruption was associated with fever and an increased neutrophil count in some cases. Symptoms were deemed to be probably or likely due to the Panax notoginseng product.”

    Panax Notoginseng · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    2 sources cited
    1. 94327. Yin Z, Ma L, Xu J, Xia J, Luo D. Pustular drug eruption due to Panax notoginseng saponins. Drug Des Devel Ther. 2014 Jul 16;8:957-61. PubMed
    2. 98976. Li C, Xu T, Zhou P, et al. Post-marketing safety surveillance and re-evaluation of Xueshuantong injection. BMC Complement Altern Med. 2018;18(1):277. PubMed

    Irbesartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Irbesartan. Read the label on DailyMed ›

Reported for Panax Notoginseng but not commonly for Irbesartan: a skin rash, numbness or tingling, anxiety or restlessness and dry mouth.

Effects for Irbesartan come from the ADVERSE REACTIONS section of its FDA label; effects for Panax Notoginseng come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 49,395 voluntary FDA FAERS reports for Irbesartan that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Panax Notoginseng in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally. Ginsenoside Rb1, an active constituent of Panax notoginseng, has teratogenic effects in animal models.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Irbesartan Is Prescribed For, and What Panax Notoginseng Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Irbesartan is a prescription medicine with approved uses on its FDA label. Panax Notoginseng is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Irbesartan is prescribed for: Irbesartan tablets — sold as Avapro and under the generic name Irbesartan — are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events, including stroke and heart attack. The medication can be used alone or combined with other blood pressure medicines. Irbesartan tablets are also used to treat diabetic nephropathy (kidney disease caused by diabetes) in adults who have type 2 diabetes, high blood pressure, elevated creatinine levels, and significant protein in the urine.

Read the rest of what Irbesartan is prescribed for

In these patients, it slows the worsening of kidney disease.

Panax Notoginseng has been studied for:

  • Stroke Natural Medicines rates the evidence for Panax Notoginseng: Possibly Effective Read what the research shows

    Panax Notoginseng for stroke

    Low-quality clinical research in patients with ischemic stroke shows that oral or intravenous Panax notoginseng may improve recovery as well as neurologic and functional scores.

  • Hypertension studied, not established Panax Notoginseng has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Panax Notoginseng for hypertension

    Although there has been interest in using oral Panax notoginseng for hypertension, there is insufficient reliable information about the clinical effects of Panax notoginseng for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Irbesartan on your own; if you are taking Panax Notoginseng for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Panax Notoginseng or Irbesartan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Panax Notoginseng or Irbesartan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Irbesartan

This page covers Panax Notoginseng only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Irbesartan page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 145 moderate · 33 minor.

Open the Irbesartan interaction page

One more smart check

Taking Panax Notoginseng as Part of a Dietary Supplement Product? Check It for Interactions

We hold 55 real supplement products containing Panax Notoginseng, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Panax Notoginseng. Even though Panax Notoginseng itself has no known interaction with Irbesartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Panax Notoginseng and Irbesartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Panax Notoginseng
Top half

#488 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Irbesartan
Top half

#1,286 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Panax Notoginseng reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Panax Notoginseng and Irbesartan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Panax Notoginseng

What is Panax Notoginseng?

Panax Notoginseng
  • Bleeding and bruising
  • Heart and circulation health
  • High blood pressure
  • Chest pain (angina)
  • Inflammation and swelling

Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evidence for these uses is limited and mostly early, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Panax notoginseng · Araliaceae · Root (and sometimes flowers and leaves) · Capsules, tablets, powders, topical preparations, and dried root used in traditional formulas

An interaction check asks whether these two react with each other — it does not ask whether Panax Notoginseng is a good idea for someone in your situation. Here is what our Panax Notoginseng record says about it on its own.

Panax Notoginseng: dosing

There is no well-established standard dose of Panax notoginseng for supplement use. Doses used in traditional practice and in studies have varied widely depending on the form and product.If you choose to use it, follow the directions on the product label and do not exceed them.

From our Panax Notoginseng monograph — the full record covers uses, side effects and every documented interaction.

Read the full Panax Notoginseng monograph & all interactions
Medication

About Irbesartan

What Is Irbesartan Used For?

Brand names: Avapro, Aprovel

Irbesartan tablets — sold as Avapro and under the generic name Irbesartan — are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events, including stroke and heart attack. The medication can be used alone or combined with other blood pressure medicines.

Irbesartan tablets are also used to treat diabetic nephropathy (kidney disease caused by diabetes) in adults who have type 2 diabetes, high blood pressure, elevated creatinine levels, and significant protein in the urine. In these patients, it slows the worsening of kidney disease.

Most-Reported Side Effects for Irbesartan

From FAERS, the FDA’s public side-effect reporting system (49,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,816 reports
Nausea 2,812 reports
Diarrhea 2,533 reports
Dizziness 2,346 reports
Dyspnea 2,251 reports
See full Irbesartan drug information
Keep checking

Other Drugs & Panax Notoginseng

Browse every other medication we’ve checked against Panax Notoginseng — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Panax Notoginseng page.

No interaction 2,622 drugs checked — show the list

We also checked Panax Notoginseng against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Panax Notoginseng list.

See the full Panax Notoginseng interactions page
See every supplement checked against Irbesartan, ranked by severity
Evidence & sources

Panax Notoginseng References

The 15 references that drive our Panax Notoginseng monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. New York, NY: CRC Press, LLC 1999:101-102.
  2. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press, 1996:359-60.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Du XF, Yin XP, Zhang GL, Shi HJ, Shao MH. Interstitial granulomatous drug reaction to a Chinese herb extract. Eur J Dermatol. 2012 May-Jun;22(3):419-20. PubMed
  5. Liu R, Qin M, Hang P, Liu Y, Zhang Z, Liu G. Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytother Res. 2012 Aug;26(8):1113-8.
  6. Shang Q, Xu H, Liu Z, Chen K, Liu J. Oral Panax notoginseng Preparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2013;2013:940125.
  7. Tian Z, Pang H, Du S, Lu Y, Zhang L, Wu H, Guo S, Wang M, Zhang Q. Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:136-143. PubMed
  8. Xu D, Huang P, Yu Z, Xing DH, Ouyang S, Xing G. Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action. Front Neurol. 2015 Jan 7;5:274. PubMed
  9. Yang X, Xiong X, Wang J. Sanqi panax notoginseng injection for angina pectoris. Evid Based Complement Alternat Med. 2014;2014:963208. PubMed
  10. Yin Z, Ma L, Xu J, Xia J, Luo D. Pustular drug eruption due to Panax notoginseng saponins. Drug Des Devel Ther. 2014 Jul 16;8:957-61. PubMed
  11. Song H, Wang P, Liu J, Wang C. Panax notoginseng Preparations for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis. Phytother Res. 2017 Jun 20.
  12. Tian Z, Pang H, Zhang Q, et al. Effect of aspirin on the pharmacokinetics and absorption of panax notoginsengsaponins. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 2;1074-75.
  13. Li C, Xu T, Zhou P, et al. Post-marketing safety surveillance and re-evaluation of Xueshuantong injection. BMC Complement Altern Med. 2018;18(1):277. PubMed
  14. Liu L, Shen XJ, Xue LJ, Yao SK, Zhu JY. Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report. World J Clin Cases 2021;9(20):5683-5688. PubMed
  15. Qian J, Chen W, Wu J, et al. Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin. Eur J Drug Metab Pharmacokinet 2022;47(3):331-342. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Panax Notoginseng and Irbesartan Together: Common Questions

Is it safe to take Panax Notoginseng with Irbesartan?
We do not list a known interaction between Panax Notoginseng and Irbesartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Panax Notoginseng and Irbesartan have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Panax Notoginseng and Irbesartan used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Panax Notoginseng in each. That is a conversation for your prescriber, especially if Irbesartan is being adjusted to a target.
How was the Panax Notoginseng and Irbesartan combination checked?
Interactions in our licensed database are recorded against drug classes. Irbesartan is filed under 4 classifications, and Panax Notoginseng has documented interactions with 4 drug classes — none of Irbesartan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Panax Notoginseng interact with any other medications?
Yes. Panax Notoginseng has 207 documented drug interactions in our database — Irbesartan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Irbesartan interact with any supplements?
Yes. Irbesartan has documented interactions with 182 supplements in our database — Panax Notoginseng is not one of them. The Irbesartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Panax Notoginseng monograph Uses, safety profile, and every drug interaction in one place Irbesartan drug information The full plain-English guide to this medication Irbesartan supplement interactions Every supplement checked against Irbesartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Irbesartan and Panax Notoginseng?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.