Drug & supplement interaction

Pu-erh Tea + Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,

Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, brand name: Allerstat.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pu-erh Tea has a moderate interaction with Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,. Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Pu-erh Tea and Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,

Here is the interaction we found between these two, with the evidence behind it.

Moderate

STIMULANT DRUGS

Why this applies to Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,

Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, falls under STIMULANT DRUGS — the group Pu-erh Tea interacts with.

Theoretically, concomitant use might increase stimulant adverse effects.
Pu-erh tea contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.
Severity Moderate Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination cold-and-allergy product, sold as Allerstat, includes phenylephrine, a decongestant that gently stimulates your system to shrink swollen nasal blood vessels. Pu-erh tea brings its own kick because it contains caffeine. When you stack a stimulant decongestant with the caffeine in pu-erh, the mild stimulant effects can add up. You might notice a faster or pounding heartbeat, jitteriness, trouble sleeping, a bump in blood pressure, or feeling wired and restless.

To be fair, this is mostly a theoretical concern based on expert opinion, and a cup or two of tea is unlikely to cause real trouble for most folks. Still, if you have high blood pressure or heart issues, or if you tend to feel buzzed from caffeine, mention it to your pharmacist or doctor before pairing them regularly.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Pu-erh Tea Also Interacts With Other Medications

Pu-erh Tea has 9 major, 447 moderate, 210 minor known drug interactions in our database — the Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, one above is one of them. If you take anything else, check it against the full list below.

Major 9 Moderate 447 Minor 210 No known interaction 2,164 (incl. Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,)
Taking anything else?

Check Another of Your Medications Against Pu-erh Tea

Covers the 2,830 medications we’ve checked against Pu-erh Tea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,

This page covers Pu-erh Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, page lists 91 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Henbane (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 7 major · 69 moderate · 15 minor.

From our pharmacist’s overview on the Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, page

“Allerstat packs two antihistamines (pheniramine and pyrilamine) alongside two decongestants (phenylephrine and phenylpropanolamine), so supplements can collide with it two ways, and this is a list I would not skim. Seven of the 91 ingredients rate major, and the rest split 69 moderate, 15 minor.”

Reviewed by 2 · Jul 18, 2026

Open the Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, interaction page

How much people look this up

Where Pu-erh Tea and Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pu-erh Tea
Steady interest

#933 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,
Top 25%

#417 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Pu-erh Tea

What is Pu-erh Tea?

  • Weight management
  • Cholesterol and heart health
  • Digestion after meals
  • Mental alertness
  • General antioxidant support

Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea. It is enjoyed worldwide as a beverage and is sometimes promoted for weight loss, cholesterol, and digestion, but human evidence for these uses is limited. As a normal drink it is generally well tolerated, though it does contain caffeine.

Read the full Pu-erh Tea monograph & all interactions
Keep checking

Other Drugs & Pu-erh Tea

Browse every other medication we’ve checked against Pu-erh Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
447Moderate
210Minor
2,163No known interaction
9 Major 447 Moderate 210 Minor 2,163 No interaction
Major

9 interactions

Moderate

447 interactions

Showing 60 of 447 moderate interactions — see all 447 on the Pu-erh Tea page.

Minor

210 interactions

Showing 60 of 210 minor interactions — see all 210 on the Pu-erh Tea page.

No interaction 2,163 drugs checked — show the list

We also checked Pu-erh Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,163 medications checked with no known interaction — see the full Pu-erh Tea list.

See the full Pu-erh Tea interactions page
See every supplement checked against Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pu-erh Tea monograph › Uses, safety, and every drug interaction in one place Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, supplement interactions › Every supplement checked against Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pu-erh Tea and Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, Together: Common Questions

Can you take Pu-erh Tea with Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine,?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Pu-erh Tea and Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pheniramine, Phenylephrine, Phenylpropan, Pyrilamine, and Pu-erh Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.