Drug & supplement interaction

Schizonepeta + Pretomanid

Pretomanid brand name: Pretomanid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Schizonepeta and Pretomanid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pretomanid states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Schizonepeta and Pretomanid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pretomanid and Schizonepeta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Schizonepeta safety at a glance

Schizonepeta overall Use caution Generally used in small amounts in traditional formulas, but high-quality safety data in humans are limited.
Pregnancy Avoid Safety in pregnancy has not been established, so it is best avoided.
Breastfeeding Avoid There is not enough information to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pretomanid and Schizonepeta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pretomanid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pretomanid is filed under 5 classifications — including immunosuppressants, qt interval-prolonging drugs, antibiotic drugs. Schizonepeta has documented interactions with 4 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2d6 (cyp2d6) substrates (moderate) and cytochrome p450 2e1 (cyp2e1) substrates (moderate) — and none of Pretomanid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Schizonepeta Does Interact With Other Medications

Schizonepeta has 797 moderate known drug interactions in our database — Pretomanid isn’t one of them. If you take anything else, check it against the full list below.

Moderate 797 No known interaction 2,033 (incl. Pretomanid)
Taking anything else?

Check Another of Your Medications Against Schizonepeta

Covers the 2,830 medications we’ve checked against Schizonepeta. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Schizonepeta and Pretomanid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Nausea / Vomiting reported in 6.2% of FDA reports for Pretomanid Additional detail

    Schizonepeta

    “There is currently a limited amount of information available about the adverse effects of schizonepeta. Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause nausea, vomiting, colic, dyspepsia, dizziness, headache, and hair loss.”

    Schizonepeta · Natural Medicines adverse-effect record, reported in alopecia.

    2 sources cited
    1. 12620. Fung D, Lau CB. Schizonepeta tenuifolia: chemistry, pharmacology, and clinical applications. J Clin Pharmacol 2002;42:30-6. PubMed
    2. 12626. Zhou S, Koh HL, Gao Y, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68. PubMed

    “Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause nausea, vomiting, colic, and dyspepsia. However, it is unclear if these effects are due to schizonepeta or the other ingredients.”

    Schizonepeta · Natural Medicines adverse-effect record, reported in dyspepsia.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Schizonepeta

    “Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause dizziness and headache. However, it is unclear if these effects are due to schizonepeta or the other ingredients.”

    Schizonepeta · Natural Medicines adverse-effect record, reported in cluster headache.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

Reported for Schizonepeta but not commonly for Pretomanid: hair loss.

Effects for Pretomanid come from the ADVERSE REACTIONS section of its FDA label; effects for Schizonepeta come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 647 voluntary FDA FAERS reports for Pretomanid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Pretomanid Products Have a Food Rule — Schizonepeta Should Not Break It

At least one FDA label for a product containing Pretomanid says to take it with food. If you take Schizonepeta on an empty stomach out of habit, keep them separate — and take Pretomanid with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pretomanid products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage Pretomanid Tablets must be administered in combination with bedaquiline and linezolid with food [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Pretomanid — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pretomanid

This page covers Schizonepeta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pretomanid page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 10 major · 122 moderate · 11 minor.

From our pharmacist’s overview on the Pretomanid page

“Pretomanid is reserved for highly drug-resistant tuberculosis, and it can stress the liver and lengthen the heart's QT interval, so the supplements on this page deserve genuine care. Ten of the 143 ingredients on file carry a major rating, and nearly all of those either compound the liver risk (alcohol in beer or wine is the plainest e…”

Reviewed by 2 · Jul 18, 2026

Open the Pretomanid interaction page

One more smart check

Taking Schizonepeta as Part of a Dietary Supplement Product? Check It for Interactions

We hold 285 real supplement products containing Schizonepeta, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Schizonepeta. Even though Schizonepeta itself has no known interaction with Pretomanid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Schizonepeta and Pretomanid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Schizonepeta
Top half

#371 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pretomanid
Steady interest

#2,135 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Schizonepeta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Schizonepeta and Pretomanid records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Schizonepeta

What is Schizonepeta?

  • Common cold and early-stage fever
  • Itchy skin rashes and hives
  • Sore throat
  • Headache
  • Measles and other skin eruptions (traditional use)

Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and itchy skin conditions. Modern human evidence is very limited, so its benefits are not well proven. Talk to a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Schizonepeta tenuifolia · Lamiaceae · Dried aerial parts (stems and flower spikes); sometimes the essential oil · Dried herb for decoctions (tea), powders, capsules, and as part of traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Schizonepeta is a good idea for someone in your situation. Here is what our Schizonepeta record says about it on its own.

Schizonepeta: dosing

There is no well-established standardized dose for Schizonepeta. In traditional Chinese medicine it is typically used as a dried herb in a decoction, often combined with other herbs, and amounts are tailored by a trained practitioner.For commercial supplements, follow the directions on the product label.

From our Schizonepeta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Schizonepeta monograph & all interactions
Medication

About Pretomanid

What Is Pretomanid Used For?

Brand name: Pretomanid

Pretomanid Tablet is used only as part of a three-drug regimen — together with bedaquiline and linezolid — to treat adults with pulmonary (lung) tuberculosis that is resistant to multiple antibiotics, including isoniazid, rifamycins, a fluoroquinolone, and a second-line injectable TB drug. It is also used for adults whose TB is resistant to isoniazid and rifampin and who cannot tolerate or are not responding to standard TB therapy.

Pretomanid Tablets are not for drug-sensitive TB, latent (inactive) TB infection, TB outside the lungs, or TB that responds to standard treatment. They should only be used in combination with bedaquiline and linezolid — safety and effectiveness with other drug combinations have not been established.

See full Pretomanid drug information
Keep checking

Other Drugs & Schizonepeta

Browse every other medication we’ve checked against Schizonepeta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
797Moderate
0Minor
2,032No known interaction
797 Moderate 2,032 No interaction
Moderate

797 interactions

Showing 60 of 797 moderate interactions — see all 797 on the Schizonepeta page.

No interaction 2,032 drugs checked — show the list

We also checked Schizonepeta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,032 medications checked with no known interaction — see the full Schizonepeta list.

See the full Schizonepeta interactions page
See every supplement checked against Pretomanid, ranked by severity
Evidence & sources

Schizonepeta References

The 4 references that drive our Schizonepeta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fung D, Lau CB. Schizonepeta tenuifolia: chemistry, pharmacology, and clinical applications. J Clin Pharmacol 2002;42:30-6. PubMed
  2. Zhou S, Koh HL, Gao Y, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68. PubMed
  3. Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 . PubMed
  4. Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Schizonepeta and Pretomanid Together: Common Questions

Is it safe to take Schizonepeta with Pretomanid?
We do not list a known interaction between Schizonepeta and Pretomanid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Schizonepeta and Pretomanid have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Schizonepeta and Pretomanid at the same time of day?
At least one FDA label for a product containing Pretomanid says to take it with food. If you take Schizonepeta on an empty stomach out of habit, keep them separate and take Pretomanid with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pretomanid products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Schizonepeta and Pretomanid combination checked?
Interactions in our licensed database are recorded against drug classes. Pretomanid is filed under 5 classifications, and Schizonepeta has documented interactions with 4 drug classes — none of Pretomanid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Schizonepeta interact with any other medications?
Yes. Schizonepeta has 797 documented drug interactions in our database — Pretomanid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pretomanid interact with any supplements?
Yes. Pretomanid has documented interactions with 143 supplements in our database — Schizonepeta is not one of them. The Pretomanid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Schizonepeta monograph Uses, safety profile, and every drug interaction in one place Pretomanid drug information The full plain-English guide to this medication Pretomanid supplement interactions Every supplement checked against Pretomanid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pretomanid and Schizonepeta?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.