Tree Turmeric + Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.
Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 drug categories that Tree Turmeric can interact with; the most serious is rated moderate. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full interaction reportTree Turmeric and Diphenhydramine Hydrochloride, Naproxen Sodium
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Tree Turmeric interacts with whole categories of medication. Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 of those categories, so it can interact with Tree Turmeric in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 3Why this applies to Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium falls under CNS DEPRESSANTS — the group Tree Turmeric interacts with.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with Aleve PM: it already contains diphenhydramine, the same sedating antihistamine found in many nighttime products. That's what makes you drowsy. Animal studies hint that berberine, the main active compound in tree turmeric, may have its own calming, sedative effect. So in theory, taking the two together could stack that drowsiness, leaving you groggier, dizzier, or more out of it than you expect.
I want to be honest though: this is based on lab and animal research, not strong human studies, so it's more of a theoretical caution than a proven problem. Still, if you tend to feel knocked out by Aleve PM, go easy and check with your pharmacist before pairing it with a berberine supplement.
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
2 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM combines naproxen (a pain and inflammation reliever) with diphenhydramine (a sedating antihistamine to help you sleep). The naproxen part is cleared by a liver enzyme called CYP2C9. Berberine, the active piece of tree turmeric, may slow that enzyme down a bit. In plain terms, your body could hang onto naproxen a little longer, which might bump up its effects and side effects.
With naproxen, that usually means more stomach upset, heartburn, or in some cases an increased risk of stomach bleeding, especially with regular use. Keep in mind this is mostly theoretical and based on weak evidence, so it may not amount to much for occasional doses. Still, it's worth a quick chat with your pharmacist or doctor before combining them, particularly if you take it often.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
3 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM is a combo of naproxen (an NSAID pain reliever) and diphenhydramine (an antihistamine that makes you sleepy). The piece that matters here is the naproxen. Like other NSAIDs, naproxen already nudges up bleeding risk on its own because it makes platelets a little less sticky and can irritate the stomach lining.
Tree turmeric (its active part, berberine) has shown in lab and animal studies that it may also slow platelets from clumping. Put the two together and, in theory, you could see a bit more bruising, nosebleeds, or stomach upset. This is only weak, theoretical evidence, so don't panic. Still, if you take Aleve PM often or have stomach or bleeding concerns, check with your pharmacist or doctor first.
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Tree Turmeric Also Interacts With Other Medications
Tree Turmeric has 2 major, 1,157 moderate known drug interactions in our database — the Diphenhydramine Hydrochloride, Naproxen Sodium one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Tree Turmeric
We haven’t checked that one against Tree Turmeric yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Tree Turmeric. Pick one to open its full report.
See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium
This page covers Tree Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 13 major · 320 moderate · 45 minor.
From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page
“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”
Reviewed by 2 · Jul 18, 2026
Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page
Taking Tree Turmeric as Part of a Dietary Supplement Product? Check It for Interactions
We hold 51 real supplement products containing Tree Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tree Turmeric. Your product may carry other ingredients that interact with Diphenhydramine Hydrochloride, Naproxen Sodium too, on top of Tree Turmeric — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Tree Turmeric and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#955 of 1,452 supplements looked up here in the last 7 days
#162 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Tree Turmeric
What is Tree Turmeric?
- Blood sugar support
- High cholesterol
- Digestive complaints
- Skin and eye conditions
- Antimicrobial uses
- Liver support
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research suggests possible benefits for blood sugar and cholesterol, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & Tree Turmeric
Browse every other medication we’ve checked against Tree Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
1,157 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Guaifenesin ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Lofepramine ›
Showing 60 of 1,157 moderate interactions — see all 1,157 on the Tree Turmeric page.
No interaction 1,670 drugs checked — show the list
We also checked Tree Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Isotretinoin ›
- Docusate ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Azithromycin ›
- Doxycycline ›
- Bendamustine ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Ezetimibe ›
- Cephalexin ›
- Cyclopentolate ›
- Avatrombopag Maleate ›
- Levodopa ›
- Thyroid Hormone ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Carbidopa, Levodopa ›
- Daunorubicin, Cytarabine ›
- Alginic Acid, Aluminum Hydroxide ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Efgartigimod Alfa-fcab ›
- Roxithromycin ›
- Charcoal (otc Drug) ›
- Cytomegalovirus Immune Globulin ›
- Peginterferon Alfa-2a, Ribavirin ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Aminolevulinic Acid Hydrochloride ›
- Magnesium Hydroxide (otc Drug) ›
- Levothyroxine Sodium ›
- Sodium Bicarbonate (otc Drug) ›
- Alpha-1 Proteinase Inhibitor ›
- Articaine, Epinephrine ›
- Tubocurarine ›
- Mitomycin ›
- Acetaminophen, Butalbital ›
- Ephedrine, Hydroxyzine, Theophylline ›
- Glycerol Phenylbutyrate ›
- Daxibotulinumtoxina-lanm ›
- Pyrilamine Maleate ›
- Ephedrine Sulfate, Hydroxyzine, Theophylline ›
- Acetaminophen, Phenylpropanolamine, Phenyltoloxamine ›
- Sulfadiazine, Trimethoprim ›
- Imipenem, Cilastatin, Relebactam ›
Showing the 60 most looked-up of 1,670 medications checked with no known interaction — see the full Tree Turmeric list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diphenhydramine Hydrochloride, Naproxen Sodium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diphenhydramine Hydrochloride, Naproxen Sodium as a medicine that can lower these. This is not an interaction with Tree Turmeric — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diphenhydramine Hydrochloride, Naproxen Sodium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Tree Turmeric and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions
Can you take Tree Turmeric with Diphenhydramine Hydrochloride, Naproxen Sodium?
Why are there 3 interactions listed for Tree Turmeric and Diphenhydramine Hydrochloride, Naproxen Sodium?
How serious is the Tree Turmeric and Diphenhydramine Hydrochloride, Naproxen Sodium interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.