Tree Turmeric + Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan brand name: Byvalson.
Nebivolol Hydrochloride, Valsartan falls into 3 drug categories that Tree Turmeric can interact with; the most serious is rated moderate. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full interaction reportTree Turmeric and Nebivolol Hydrochloride, Valsartan
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Tree Turmeric interacts with whole categories of medication. Nebivolol Hydrochloride, Valsartan falls into 3 of those categories, so it can interact with Tree Turmeric in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 3Why this applies to Nebivolol Hydrochloride, Valsartan
Nebivolol Hydrochloride, Valsartan falls under ANTIHYPERTENSIVE DRUGS — the group Tree Turmeric interacts with.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two blood pressure medicines: nebivolol (a beta-blocker) and valsartan (an ARB). The concern here isn't about your liver breaking down the drug differently. Instead, tree turmeric (through its main compound, berberine) may gently lower blood pressure on its own. Stacked on top of Byvalson, the two could add up and push your pressure a bit too low.
If that happens, you might feel dizzy, lightheaded, unusually tired, or notice your heart beating slowly, especially when standing up quickly. I want to be honest though: this is mostly theoretical, based on animal studies and limited human data, so it may not affect you at all. Still, if you'd like to try tree turmeric, check with your pharmacist or doctor first and keep an eye on your readings.
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two medicines: nebivolol (a beta-blocker) and valsartan. The piece that matters here is nebivolol, which your body clears mainly through a liver enzyme called CYP2D6. Berberine, the active part of tree turmeric, appears to slow that enzyme down. So in theory, taking concentrated tree turmeric supplements could let nebivolol build up a bit more than usual.
If that happens, you might notice the beta-blocker effects getting stronger: a slower heart rate, lower blood pressure, dizziness, or feeling unusually tired. The evidence here is still limited and partly theoretical, so this is not a reason to panic. But since both work on blood pressure, it's worth a quick chat with your pharmacist or doctor before adding this supplement.
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 3Nebivolol Hydrochloride, Valsartan also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Byvalson combines two blood pressure medicines: nebivolol (a beta-blocker) and valsartan. Berberine, the active part of tree turmeric, may gently block an enzyme called CYP2C9, which is one of the pathways your body uses to clear the valsartan piece of this combo. If that pathway slows down, valsartan could build up a little, which might lower your blood pressure more than expected.
In real life, that could mean feeling dizzy, lightheaded, unusually tired, or faint when you stand up. Keep in mind this is mostly theoretical and based on early, lower-quality evidence, so it may not happen at all. Still, before adding a berberine supplement, check with your pharmacist or doctor. Please don't stop or change your Byvalson on your own.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Tree Turmeric Also Interacts With Other Medications
Tree Turmeric has 2 major, 1,157 moderate known drug interactions in our database — the Nebivolol Hydrochloride, Valsartan one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Tree Turmeric
We haven’t checked that one against Tree Turmeric yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Tree Turmeric. Pick one to open its full report.
See Every Supplement That Interacts With Nebivolol Hydrochloride, Valsartan
This page covers Tree Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nebivolol Hydrochloride, Valsartan page lists 213 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
By severity: 5 major · 173 moderate · 35 minor.
From our pharmacist’s overview on the Nebivolol Hydrochloride, Valsartan page
“Nebivolol with valsartan (Byvalson) packs two blood pressure medicines into one pill, and I would treat this list with genuine care, especially its handful of serious entries. Most of the interactions tug on blood pressure itself, some deepening the drop until dizziness or fainting becomes a risk, others, tyramine among them, pushing p…”
Reviewed by 2 · Jul 18, 2026
Open the Nebivolol Hydrochloride, Valsartan interaction page
Taking Tree Turmeric as Part of a Dietary Supplement Product? Check It for Interactions
We hold 51 real supplement products containing Tree Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tree Turmeric. Your product may carry other ingredients that interact with Nebivolol Hydrochloride, Valsartan too, on top of Tree Turmeric — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Tree Turmeric and Nebivolol Hydrochloride, Valsartan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#750 of 1,452 supplements looked up here in the last 7 days
#281 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Tree Turmeric
What is Tree Turmeric?
- Blood sugar support
- High cholesterol
- Digestive complaints
- Skin and eye conditions
- Antimicrobial uses
- Liver support
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research suggests possible benefits for blood sugar and cholesterol, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & Tree Turmeric
Browse every other medication we’ve checked against Tree Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
1,157 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Guaifenesin ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Lofepramine ›
Showing 60 of 1,157 moderate interactions — see all 1,157 on the Tree Turmeric page.
No interaction 1,670 drugs checked — show the list
We also checked Tree Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Isotretinoin ›
- Docusate ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Methotrexate ›
- Amoxicillin ›
- Levothyroxine, Liothyronine ›
- Bupropion ›
- Bendamustine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Ezetimibe ›
- Cyclopentolate ›
- Cephalexin ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Thyroid Hormone ›
- Levodopa ›
- Carbidopa, Levodopa ›
- Roxithromycin ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Alginic Acid, Aluminum Hydroxide ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Mitomycin ›
- Magnesium Hydroxide (otc Drug) ›
- Avatrombopag Maleate ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Flutemetamol F-18 ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Cefaclor ›
- Articaine, Epinephrine ›
- Daptomycin ›
- Peginterferon Alfa-2a, Ribavirin ›
- Acetaminophen, Butalbital ›
- Charcoal (otc Drug) ›
- Digoxin ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Hydroxychloroquine ›
- Alpha-1 Proteinase Inhibitor ›
- Colistin, Neomycin, Hydrocortisone ›
- Aminolevulinic Acid Hydrochloride ›
- Daunorubicin, Cytarabine ›
- Alendronate Sodium, Cholecalciferol ›
- Factor 7a ›
- Efgartigimod Alfa-fcab ›
- Hexobarbitone ›
- Rosuvastatin Calcium, Ezetimibe ›
- Pegunigalsidase Alfa-iwxj ›
Showing the 60 most looked-up of 1,670 medications checked with no known interaction — see the full Tree Turmeric list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Nebivolol Hydrochloride, Valsartan Is Linked to Lower Levels of One Nutrient
Natural Medicines records Nebivolol Hydrochloride, Valsartan as a medicine that can lower these. This is not an interaction with Tree Turmeric — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Nebivolol Hydrochloride, Valsartan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Tree Turmeric and Nebivolol Hydrochloride, Valsartan Together: Common Questions
Can you take Tree Turmeric with Nebivolol Hydrochloride, Valsartan?
Why are there 3 interactions listed for Tree Turmeric and Nebivolol Hydrochloride, Valsartan?
How serious is the Tree Turmeric and Nebivolol Hydrochloride, Valsartan interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.