Drug & supplement interaction

Tronadora + Metformin, Rosiglitazone

Metformin, Rosiglitazone brand name: Avandamet.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Tronadora has a moderate interaction with Metformin, Rosiglitazone. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Tronadora and Metformin, Rosiglitazone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Metformin, Rosiglitazone

Metformin, Rosiglitazone falls under ANTIDIABETES DRUGS — the group Tronadora interacts with.

Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia. Clinical research suggests that a combination of tronadora and Guazuma ulmifolia reduce levels of fasting glucose in patients with type 2 diabetes, including those already taking antidiabetes agents. The effect of tronadora alone is unknown. Animal research is conflicting.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Avandamet combines two diabetes medicines, metformin and rosiglitazone, both of which work to lower your blood sugar. Tronadora is a folk-remedy plant tea that some small studies suggest may nudge blood sugar down too. Stack the two together and the worry is simple: your sugar could drop lower than intended. That's called hypoglycemia, and it can leave you shaky, sweaty, dizzy, hungry, or confused.

I want to be honest about how solid this is. The evidence is thin and partly theoretical, and the studies that showed an effect actually paired tronadora with another herb, so tronadora's effect on its own isn't really known. Still, since it's about your blood sugar, please check with your pharmacist or doctor before combining them, and keep an eye on your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Costantino L, Raimondi L, Pirisino R, et al. Isolation and pharmacological activities of the Tecoma stans alkaloids. Farmaco 2003;58:781-5. PubMed
  2. Meckes-Lozoya M, Ibanez-Camacho R. Hepatic glycogenolysis produced by intraperitoneal administration of total extract of Tecoma stans in rats. Arch Invest Med (Mex) 1985;16:387-9.
  3. Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, et al. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex) 1991;22:87-93.
  4. Pascoe-González S, Ramos-Zavala MG, Buenrostro Ahued MA, et al. Administration of herbarium mixture (Guazuma ulmifolia/Tecoma stans) on metabolic profile in type 2 diabetes mellitus patients: A randomized, double-blind, placebo-controlled trial. J Med Foo
  5. Gupta A, Behl T, Sehgal A, et al. Elucidating the neuroprotective effect of Tecoma stans leaf extract in STZ-induced diabetic neuropathy. Evid Based Complement Alternat Med 2022;2022:3833392. PubMed
  6. Morales-Ferra DL, Zavala-Sánchez MÁ, Jiménez-Ferrer E, González-Cortazar M, Zamilpa A. Effect of Tecoma stans (L.) Juss. ex Kunth in a murine model of metabolic syndrome. Plants (Basel) 2022;11(14):1794. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Tronadora Also Interacts With Other Medications

Tronadora has 85 moderate known drug interactions in our database — the Metformin, Rosiglitazone one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Metformin, Rosiglitazone)
Taking anything else?

Check Another of Your Medications Against Tronadora

Covers the 2,830 medications we’ve checked against Tronadora. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Metformin, Rosiglitazone

This page covers Tronadora only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metformin, Rosiglitazone page lists 315 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 268 moderate · 43 minor.

From our pharmacist’s overview on the Metformin, Rosiglitazone page

“Avandamet pairs metformin with rosiglitazone to manage type 2 diabetes, and its supplement list calls for genuine care rather than a quick skim. Start with the four major-rated entries: alcohol and the herb Siberian cocklebur can each stress the liver, a serious concern with rosiglitazone on board, while activated charcoal can soak up…”

Reviewed by 2 · Jul 18, 2026

Open the Metformin, Rosiglitazone interaction page

How much people look this up

Where Tronadora and Metformin, Rosiglitazone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tronadora
Steady interest

#825 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metformin, Rosiglitazone
Top 25%

#644 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Tronadora

What is Tronadora?

  • Blood sugar control / diabetes
  • Digestive complaints
  • Mild fever
  • Yeast or fungal concerns
  • Traditional 'tonic' use

Tronadora (Tecoma stans) is a flowering shrub used in Mexican and Latin American folk medicine, most often as a tea for diabetes and digestive complaints. Human evidence is very limited, so it should not replace proven treatments. Because it may affect blood sugar and its safety is not well studied, talk to your pharmacist or doctor before using it—and avoid it during pregnancy and breastfeeding.

Read the full Tronadora monograph & all interactions
Keep checking

Other Drugs & Tronadora

Browse every other medication we’ve checked against Tronadora — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Tronadora page.

No interaction 2,744 drugs checked — show the list

We also checked Tronadora against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Tronadora list.

See the full Tronadora interactions page
See every supplement checked against Metformin, Rosiglitazone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Tronadora monograph › Uses, safety, and every drug interaction in one place Metformin, Rosiglitazone supplement interactions › Every supplement checked against Metformin, Rosiglitazone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Tronadora and Metformin, Rosiglitazone Together: Common Questions

Can you take Tronadora with Metformin, Rosiglitazone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Tronadora and Metformin, Rosiglitazone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Metformin, Rosiglitazone and Tronadora?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.