Drug & supplement interaction

Tronadora + Sotorasib

Sotorasib brand name: Lumakras.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tronadora and Sotorasib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tronadora and Sotorasib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sotorasib and Tronadora in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tronadora safety at a glance

Tronadora overall Use caution Limited human safety data; may affect blood sugar, so use with care and medical guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sotorasib and Tronadora? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sotorasib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sotorasib is filed under 4 classifications — including cytochrome p450 3a4 (cyp3a4) inducers, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Tronadora has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Sotorasib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tronadora Does Interact With Other Medications

Tronadora has 86 moderate known drug interactions in our database — Sotorasib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Sotorasib)
Taking anything else?

Check Another of Your Medications Against Tronadora

Covers the 2,830 medications we’ve checked against Tronadora. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tronadora and Sotorasib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Tronadora

    “There is currently a limited amount of information available about adverse effects of tronadora. Topically, tronadora might cause allergic dermatitis.”

    Tronadora · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 96666. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed

    “Topically, tronadora might cause allergic dermatitis. In one case report, an Indian woman that regularly plucked tronadora flowers as part of her morning pooja ritual developed allergic dermatitis.”

    Tronadora · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 96666. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed

    Sotorasib

    Listed in the ADVERSE REACTIONS section of the FDA label for Sotorasib. Read the label on DailyMed ›

Effects for Sotorasib come from the ADVERSE REACTIONS section of its FDA label; effects for Tronadora come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Sotorasib

This page covers Tronadora only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sotorasib page lists 180 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 137 moderate · 37 minor.

From our pharmacist’s overview on the Sotorasib page

“Grapefruit is the first thing I would drop while on sotorasib (Lumakras), a targeted lung cancer pill cleared by the CYP3A4 enzyme. Grapefruit blocks that enzyme and can push sotorasib levels up; St.”

Reviewed by 2 · Jul 18, 2026

Open the Sotorasib interaction page

How much people look this up

Where Tronadora and Sotorasib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tronadora
Steady interest

#907 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sotorasib
Steady interest

#1,996 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tronadora reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tronadora and Sotorasib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tronadora

What is Tronadora?

  • Blood sugar control / diabetes
  • Digestive complaints
  • Mild fever
  • Yeast or fungal concerns
  • Traditional 'tonic' use

Tronadora (Tecoma stans) is a flowering shrub used in Mexican and Latin American folk medicine, most often as a tea for diabetes and digestive complaints. Human evidence is very limited, so it should not replace proven treatments. Because it may affect blood sugar and its safety is not well studied, talk to your pharmacist or doctor before using it—and avoid it during pregnancy and breastfeeding.

Tecoma stans · Bignoniaceae · Leaves, flowers, and sometimes roots and bark · Tea (infusion), dried herb, capsules, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Tronadora is a good idea for someone in your situation. Here is what our Tronadora record says about it on its own.

Tronadora: dosing

There is no established, standardized dose for Tronadora. Traditional use is often as a tea made from the dried leaves or flowers, but the amount of active compounds can vary a lot between products and batches.If you choose to use it, follow the directions on the product label and start low.

From our Tronadora monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tronadora monograph & all interactions
Medication

About Sotorasib

What Is Sotorasib Used For?

Brand name: Lumakras

Lumakras is used to treat adults with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) who have already received at least one prior cancer treatment. This use was approved under the FDA's accelerated approval pathway based on tumor response rates, and continued approval may depend on results from confirmatory trials.

Lumakras is also used in combination with panitumumab to treat adults with KRAS G12C-mutated metastatic colorectal cancer (mCRC) who have previously received certain chemotherapy regimens. In both cases, patients must first be confirmed to carry the KRAS G12C mutation using an FDA-approved test.

Most-Reported Side Effects for Sotorasib

From FAERS, the FDA’s public side-effect reporting system (3,319 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Non-small cell lung cancer 511 reports
Disease progression 342 reports
Diarrhea 325 reports
Nausea 113 reports
Fatigue 107 reports
See full Sotorasib drug information
Keep checking

Other Drugs & Tronadora

Browse every other medication we’ve checked against Tronadora — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Tronadora page.

No interaction 2,743 drugs checked — show the list

We also checked Tronadora against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Tronadora list.

See the full Tronadora interactions page
See every supplement checked against Sotorasib, ranked by severity
Evidence & sources

Tronadora References

The 7 references that drive our Tronadora monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Costantino L, Raimondi L, Pirisino R, et al. Isolation and pharmacological activities of the Tecoma stans alkaloids. Farmaco 2003;58:781-5. PubMed
  2. Meckes-Lozoya M, Ibanez-Camacho R. Hepatic glycogenolysis produced by intraperitoneal administration of total extract of Tecoma stans in rats. Arch Invest Med (Mex) 1985;16:387-9.
  3. Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, et al. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex) 1991;22:87-93.
  4. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed
  5. Pascoe-González S, Ramos-Zavala MG, Buenrostro Ahued MA, et al. Administration of herbarium mixture (Guazuma ulmifolia/Tecoma stans) on metabolic profile in type 2 diabetes mellitus patients: A randomized, double-blind, placebo-controlled trial. J Med Foo
  6. Gupta A, Behl T, Sehgal A, et al. Elucidating the neuroprotective effect of Tecoma stans leaf extract in STZ-induced diabetic neuropathy. Evid Based Complement Alternat Med 2022;2022:3833392. PubMed
  7. Morales-Ferra DL, Zavala-Sánchez MÁ, Jiménez-Ferrer E, González-Cortazar M, Zamilpa A. Effect of Tecoma stans (L.) Juss. ex Kunth in a murine model of metabolic syndrome. Plants (Basel) 2022;11(14):1794. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tronadora and Sotorasib Together: Common Questions

Is it safe to take Tronadora with Sotorasib?
We do not list a known interaction between Tronadora and Sotorasib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tronadora and Sotorasib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Tronadora and Sotorasib combination checked?
Interactions in our licensed database are recorded against drug classes. Sotorasib is filed under 4 classifications, and Tronadora has documented interactions with 1 drug class — none of Sotorasib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tronadora interact with any other medications?
Yes. Tronadora has 86 documented drug interactions in our database — Sotorasib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sotorasib interact with any supplements?
Yes. Sotorasib has documented interactions with 180 supplements in our database — Tronadora is not one of them. The Sotorasib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tronadora monograph Uses, safety profile, and every drug interaction in one place Sotorasib drug information The full plain-English guide to this medication Sotorasib supplement interactions Every supplement checked against Sotorasib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sotorasib and Tronadora?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.