Herb & supplement monograph

Cissus Quadrangularis Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Cissus Quadrangularis interacts with medications. The heart of this page is the interaction list — every drug Cissus Quadrangularis is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Cissus Quadrangularis is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Cissus Quadrangularis against your medication

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Reviewed by licensed pharmacists Sourced from Natural Medicines
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Interaction report

Drugs that interact with Cissus Quadrangularis

86 medications have a known interaction with Cissus Quadrangularis, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Acetohexamide interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Albiglutide interaction
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Alogliptin, Pioglitazone interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
CanagliflozinInvokana
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effects
Canagliflozin, MetforminInvokamet
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Canagliflozin, Metformin interaction
Canagliflozin, Metformin HydrochlorideInvokamet XR
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Canagliflozin, Metformin Hydrochloride interaction
ChlorpropamideChlorpropam, Diabinese
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Chlorpropamide interaction
DapagliflozinFarxiga
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effects
Dapagliflozin Propanediol, MetforminXigduo XR
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dapagliflozin Propanediol, Metformin interaction
Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interaction
Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interaction
Dasiglucagon HydrochlorideZegalogue
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effects
DulaglutideTrulicity
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effects
EmpagliflozinJardiance
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effects
Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Empagliflozin, Linagliptin, Metformin Hydrochloride interaction
Empagliflozin, MetforminSynjardy
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Empagliflozin, Metformin interaction
Empagliflozin, Metformin HydrochlorideSynjardy XR
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Empagliflozin, Metformin Hydrochloride interaction
ErtugliflozinSteglatro
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effects
Ertugliflozin, Metformin HydrochlorideSegluromet
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Ertugliflozin, Metformin Hydrochloride interaction
ExenatideBydureon, Byetta
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Exenatide interaction Exenatide drug page: uses, dosage & side effects
Exenatide SyntheticBydureon BCISE
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effects
GliclazideDiamicron
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Gliclazide interaction
GlimepirideAmaryl
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Glimepiride interaction Glimepiride drug page: uses, dosage & side effects
GlipizideGlucotrol, Glucotrol XL
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Glipizide interaction Glipizide drug page: uses, dosage & side effects
Glipizide, MetforminMetaglip
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Glipizide, Metformin interaction
GlucagonBaqsimi, Glucagon
Moderate Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full Cissus Quadrangularis + Glucagon interaction Glucagon drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Cissus Quadrangularis combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Cissus Quadrangularis affects

Every type of medication (drug category) Cissus Quadrangularis is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Cissus Quadrangularis interacts with
Antidiabetes Drugs
Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Monograph

Cissus Quadrangularis: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of human trials, so its benefits are not firmly proven. It appears reasonably well tolerated in the short term, but people who are pregnant, breastfeeding, or managing chronic conditions should talk to a doctor or pharmacist first.

Cissus Quadrangularis
Scientific name
Cissus quadrangularis
Family
Vitaceae
Part used
Stems, leaves, and roots
Common forms
Capsules, tablets, powder, extracts, and topical preparations
People commonly use it for
  • Bone fracture healing
  • Joint pain and bone health
  • Weight management
  • Blood sugar support
  • Digestive complaints

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in short-term use, but long-term safety is not well studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Cissus quadrangularis is a climbing vine that belongs to the grape family (Vitaceae). It is sometimes called veldt grape or adamant creeper. It grows in warmer parts of the world, including India, Africa, and parts of Asia.

The plant has a long history in traditional medicine systems, especially in India, where it has been used to help broken bones heal and to ease digestive problems. Today it is sold as a dietary supplement in capsules, tablets, powders, and extracts. Some products are also applied to the skin.

How it works

Cissus quadrangularis contains a mix of natural compounds, including flavonoids, plant steroids, vitamin C, and antioxidants. These substances are thought to be behind its possible effects.

In laboratory and animal studies, the plant appears to encourage the activity of bone-building cells (osteoblasts) and reduce the activity of cells that break down bone (osteoclasts). It may also help lower inflammation and protect cells from damage caused by unstable molecules called free radicals.

It is important to remember that most of these mechanisms come from test-tube and animal research. We do not yet know how strongly these effects translate to people.

Effectiveness

Does Cissus Quadrangularis work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 17 uses evaluated
1 Possibly effective 16 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Obesity
Rating & evidence shown verbatim from Natural Medicines

Several small clinical studies suggest that oral Cissus quadrangularis extract, taken with or without other ingredients, can decrease body weight in those who are overweight or obese.

Also studied for 16 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for asthma, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for cancer, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for diabetes, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Epilepsy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for epilepsy, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Fractures
Rating & evidence shown verbatim from Natural Medicines

Several small, low-quality clinical trials suggest that oral Cissus quadrangularis may accelerate the healing of various types of fractures and reduce pain and swelling.

Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for gout, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral or topical Cissus quadrangularis extracts may not improve symptoms of hemorrhoids.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for hyperlipidemia there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Joint pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Cissus quadrangularis is beneficial in patients with joint pain.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for metabolic syndrome, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis to improve muscle strength, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Osteopenia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Cissus quadrangularis is beneficial for osteopenia.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for osteoporosis, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Peptic ulcers
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for peptic ulcers, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Cissus quadrangularis for RA, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical Cissus quadrangularis for wound healing, there is insufficient reliable information about the clinical effects of Cissus quadrangularis for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Cissus quadrangularis appears to be reasonably well tolerated when used short term in studies. However, its long-term safety has not been carefully studied, and the quality of supplements can vary between brands.

People with diabetes should use caution, since the plant may affect blood sugar. Those with any chronic medical condition should check with a doctor or pharmacist before starting.

Pregnancy and breastfeeding: There is not enough reliable safety information for these groups. To be safe, it is best to avoid Cissus quadrangularis if you are pregnant or breastfeeding.

Side effects

Reported side effects are usually mild and may include headache, gas, diarrhea, dry mouth, or upset stomach.

Serious side effects have not been commonly reported, but because long-term and large studies are lacking, the full safety picture is not known. Stop using it and contact a healthcare provider if you notice an allergic reaction or any unusual or severe symptoms.

Cissus Quadrangularis: Reported Adverse Effects

Documented safety reports on Cissus Quadrangularis from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Cluster headache Neurologic/CNS

Orally, Cissus quadrangularis has been reported to cause headache and insomnia. However, the rates of these adverse effects are similar to or lower than that observed with placebo.

  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
Diarrhea Gastrointestinal

Orally, Cissus quadrangularis has been reported to cause flatulence, diarrhea, gastritis, and dry mouth. However, the rates of these adverse effects are similar to or lower than that observed with placebo.

  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1
  4. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official, standardized dose for Cissus quadrangularis. Products differ widely in their strength and how they are prepared, which makes a single recommended dose hard to give.

The best approach is to follow the directions on the product label and not exceed the suggested amount. A pharmacist or doctor can help you decide whether a product and dose make sense for you, especially if you take other medicines or have health conditions.

Pregnancy & Breastfeeding

Cissus Quadrangularis & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Cissus Quadrangularis & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Cissus Quadrangularis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Cissus Quadrangularis

145 brands in our database make a supplement containing Cissus Quadrangularis.

Product directory

Supplement products with Cissus Quadrangularis

373 products in our database contain Cissus Quadrangularis. Open any to see its full ingredient list and every drug interaction we check.

After Glow Natural Watermelon by BioRhythm Powder 4.23 lbs · 1920 Gram(s) Off market View ingredients & interactions After Glow Orange Zest by BIORhythm Powder 4.23 lbs · 1920 Gram(s) Off market View ingredients & interactions After Glow Post Workout Euphoria Bazooka Fruit by BioRhythm Powder 1920 g · 4 lb Off market View ingredients & interactions After Glow Post Workout Euphoria Bazooka Fruit by BioRhythm Powder 960 g · 2 lb Off market View ingredients & interactions After Glow Post Workout Euphoria Cherry Bomb by BioRhythm Powder 1920 g · 4 lb Off market View ingredients & interactions After Glow Post Workout Euphoria Cherry Bomb by BioRhythm Powder 960 g · 2 lb Off market View ingredients & interactions After Glow Post Workout Euphoria Orange Pushup by BioRhythm Powder 1920 Gram(s) · 4.23 lbs Off market View ingredients & interactions After Glow Post Workout Euphoria Orange Pushup by BioRhythm Powder 960 Gram(s) · 2.12 lbs Off market View ingredients & interactions After Glow Post Workout Euphoria Watermelon by BioRhythm Powder 1920 g · 4 lb Off market View ingredients & interactions After Glow Watermelon by BioRhythm Powder 960 Gram(s) · 2.12 lb Off market View ingredients & interactions After Glow Watermelon Original Flavor by BioRhythm Powder 2.12 lbs · 960 Gram(s) Off market View ingredients & interactions Ageless Male by New Vitality Softgel Capsule 60 Softgel(s) Off market View ingredients & interactions Aggression by Enraged Capsule 90 Capsule(s) Off market View ingredients & interactions Aggression by EN Enraged Capsule 90 Capsule(s) Off market View ingredients & interactions Aggression by EN Enraged Capsule 90 Capsule(s) Off market View ingredients & interactions Aid 4 Joints by Ox Nutrition Capsule 120 Capsule(s) Off market View ingredients & interactions Aid 4 Joints by Pure Advantage Capsule 120 Capsule(s) Off market View ingredients & interactions Alpha Elite by Invictus Labs Capsule 90 Capsule(s) Off market View ingredients & interactions Alpha Mode by Life's Armour Capsule 90 Capsule(s) Off market View ingredients & interactions Amino Linx BCAA & EAA Matrix Cherry Splash by PS ProSupps Powder 14.3 oz. · 405 Gram(s) Off market View ingredients & interactions Amino Linx BCAA & EAA Matrix Mango Passion Fruit by PS ProSupps Powder 14.3 oz. · 405 Gram(s) Off market View ingredients & interactions Amino Linx Cherry Bomb by PS ProSupps Powder 14.3 oz. · 405 Gram(s) Off market View ingredients & interactions AminoLinx Berry Blast by PS ProSupps Powder 14.3 oz. · 405 Gram(s) Off market View ingredients & interactions AminoLinx Cherry Bomb by PS ProSupps Powder 14.3 oz. · 405 Gram(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Cissus Quadrangularis: Common Questions

What is Cissus Quadrangularis used for, and does it work?
People use Cissus Quadrangularis for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Cissus Quadrangularis for Obesity. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Cissus Quadrangularis interact with prescription medications?
Yes. We list 86 medications with a known interaction with Cissus Quadrangularis. Use the checker above to see how Cissus Quadrangularis interacts with a specific drug.
How are Cissus Quadrangularis interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Cissus Quadrangularis with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Cissus Quadrangularis interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Cissus Quadrangularis used for?
It is most often used for bone and joint health, weight management, and blood sugar support. Its traditional reputation is for helping broken bones heal, though human evidence for most uses is still limited.
Is Cissus Quadrangularis safe to take?
It appears reasonably well tolerated for short-term use, with mostly mild side effects like headache or stomach upset. Long-term safety has not been well studied, so it is wise to talk to a pharmacist or doctor first.
Can I take it while pregnant or breastfeeding?
There is not enough safety information for these situations, so it is best to avoid Cissus Quadrangularis if you are pregnant or breastfeeding.
Does Cissus Quadrangularis really help with weight loss?
Some small studies suggest possible effects on weight and waist size, often in combination products, but the evidence is not strong enough to consider it a proven weight-loss aid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Cissus Quadrangularis

A rotating sample of real supplements in our database that list Cissus Quadrangularis — open any to see its full ingredients and every drug interaction we check.

See all 373 products with Cissus Quadrangularis →
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