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Dietary supplement

Ciccus Quadrangularis 1200 mg Ingredients & Drug Interactions

by longlifenutri

Ciccus Quadrangularis 1200 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ciccus Quadrangularis 1200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ciccus Quadrangularis 1200 mg is a dietary supplement by longlifenutri with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis Stem Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ciccus Quadrangularis 1200 mg by longlifenutri

Ask about any prescription or over-the-counter medication and we check it for interactions with Ciccus Quadrangularis 1200 mg by longlifenutri — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ciccus Quadrangularis 1200 mg by longlifenutri

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: Cissus quadrangularis Stem Extract, a botanical extract from a tropical climbing plant, supplied at 1200 mg per capsule. The capsule itself is made of inactive ingredients — cellulose, magnesium stearate (a flow agent), and rice flour — which are excipients that hold the extract in form.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint health and bone structure support.
  • We looked for evidence on: Joint pain, Osteoporosis, Osteopenia, Fractures, Rheumatoid arthritis (RA), bone density — and 2 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Joint pain, Rheumatoid arthritis (RA), Osteopenia.

Cissus quadrangularis is rated possibly effective for obesity — small clinical evidence suggests it may help reduce fasting blood sugar in people who are overweight or obese. For other uses on file here — high cholesterol, weak bones, cancer, and epilepsy — the evidence is insufficient to rate it.

That doesn't mean it doesn't work; it means the data we hold isn't strong enough yet to say either way.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, but long-term safety hasn't been well studied, so caution is warranted if you're thinking of taking it for months or longer. In clinical trials, headache, insomnia, flatulence, diarrhea, gastritis (stomach inflammation), and dry mouth have been reported, but the rates of these side effects matched or were lower than placebo — meaning they're uncommon.

There isn't enough safety data to know whether this supplement is okay during pregnancy or while breastfeeding. If you're pregnant, nursing, or planning either, talk with your doctor or pharmacist before taking it to weigh what you know against what's uncertain.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes medication — insulin, metformin, sulfonylureas, GLP-1 agonists, or others — talk with your doctor or pharmacist before adding this supplement. There's a moderate risk that Cissus quadrangularis could increase the likelihood of low blood sugar when combined with diabetes drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support weight management or blood sugar control, Cissus quadrangularis may be worth a conversation with your doctor — early evidence is promising for obesity. If you take diabetes medication, this is essential to discuss first, because of the risk of low blood sugar.

Check with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ciccus Quadrangularis 1200 mg, straight from the product label.

Brand longlifenutri
Barcode (UPC) X001E702WZ
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 313662
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ciccus Quadrangularis 1200 mg by longlifenutri, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
X001E702WZ
IngredientAmount% DV
Cissus quadrangularis Stem Extract1200 mg--

Other ingredients: Cellulose, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports Optimal Joint Health Promotes Healthy Bone Structure Reduces Joint Pain Helps Lower Cortisol Levels

Gluten Free GMO Free

No Fillers or artificial ingredients Wheat Gluten Soybeans Dairy Egg Fish Shellfish Tree nuts

Seals/Symbols

Quality Assured GMP Certified Made in USA

Premium Quality Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take two (2) vegetarian capsules daily, preferably 30 minutes prior to meals or as directed by your healthcare professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Premium Quality Dietary Supplement

Precautions

Keep out of reach of children.

Caution: Do not exceed the recommended dose.

Pregnant or nursing women, under the age of 18 or individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Discontinue use if you experience any adverse reaction to this product.

Pregnant or nursing women, under the age of 18 or individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store in a cool, dry place.

Formula

Cissus Quadrangularis 1200 mg per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ciccus Quadrangularis 1200 mg by longlifenutri label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ciccus Quadrangularis 1200 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ciccus Quadrangularis 1200 mg by longlifenutri

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Cissus quadrangularis Stem Extract

Interacts with
86 drugs
1200 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis Stem Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ciccus Quadrangularis 1200 mg by longlifenutri Drug Interactions

Want to check YOUR meds against Ciccus Quadrangularis 1200 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis Stem Extract 86

Individual Drug Interactions

The ingredients in Ciccus Quadrangularis 1200 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ciccus Quadrangularis 1200 mg interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis Stem Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ciccus Quadrangularis 1200 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis Stem Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis Stem Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ciccus Quadrangularis 1200 mg, from the product label.

longlifenutri

See all longlifenutri products
Name
LongLifeNutri
City
Minden
State
NV
ZipCode
89423
Phone Number
347-960-6755
Web Address
www.longlifenutri.com
Pharmacist Counseling Corner

Ciccus Quadrangularis 1200 mg by longlifenutri: Common Questions

Does Ciccus Quadrangularis 1200 mg by longlifenutri interact with any medications?
Yes. Based on its ingredients, Ciccus Quadrangularis 1200 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ciccus Quadrangularis 1200 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Cissus quadrangularis actually work for weight loss?
Early evidence rates it possibly effective for obesity. Small clinical studies show it may help lower fasting blood glucose in people who are overweight or obese, but we don't have large, long-term trials yet. It's a "maybe worth trying" situation — not a proven solution, but not ruled out either.
Is it safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking of taking it for months, that's a good conversation to have with your doctor or pharmacist.
What side effects should I watch for?
Headache, insomnia, flatulence, diarrhea, stomach inflammation, and dry mouth have been reported. The good news: in trials, these happened about as often — or less often — than with placebo, so they're uncommon.
Can I take it if I'm pregnant or breastfeeding?
There isn't enough safety data to know. The facts advise against it during pregnancy and breastfeeding. Talk with your doctor or pharmacist to weigh the unknowns for your situation.
What is Cissus quadrangularis?
It's a stem extract from a tropical climbing plant. This product delivers 1200 mg of that extract per capsule.
Does it help with cholesterol, bone health, or other conditions?
We have insufficient evidence to rate it for high cholesterol, weak bones, cancer, or epilepsy. That means the research on file isn't strong enough to say whether it works for those uses yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ciccus Quadrangularis 1200 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ciccus Quadrangularis 1200 mg label
Go deeper

The Full Monographs Behind Ciccus Quadrangularis 1200 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Ciccus Quadrangularis 1200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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