Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Cissus Max Ingredients & Drug Interactions

by Good State

Cissus Max label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Max against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Max is a dietary supplement by Good State with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cissus Max by Good State

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Max by Good State — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Cissus Max by Good State

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cissus Max contains one active ingredient: Cissus quadrangularis extract, a plant-based ingredient traditionally used to support bone and joint health. The capsule itself is filled with cellulose, an inactive ingredient that serves as a filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote and maintain healthy joints.
  • We looked for evidence on: Fractures, Joint pain, Osteopenia, Osteoporosis, Rheumatoid arthritis (RA), Cartilage health — and 1 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain, Rheumatoid arthritis (RA).

Cissus quadrangularis extract is rated possibly effective for obesity, based on available research. For high cholesterol (hyperlipidemia), bone loss (osteopenia), cancer, and epilepsy, the evidence is currently insufficient to rate how well it works.

If you're considering this supplement for any of those latter conditions, the data we hold doesn't establish whether it's effective.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been thoroughly studied. The most commonly reported side effects—headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth—occur at rates similar to or lower than placebo in trials.

During pregnancy, there isn't enough safety data, so it's best avoided. The same applies to breastfeeding.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs—insulin, metformin, sulfonylureas, or similar medications that lower blood sugar—check with your doctor or pharmacist before starting Cissus Max. This supplement may theoretically increase the risk of low blood sugar (hypoglycemia) when combined with these medications, a Moderate-severity interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus Max may be worth considering if you're managing weight and want to explore botanical options—but it's not proven for other uses listed on the label. If you take any blood-sugar-lowering medication, you'll want to check with your doctor or pharmacist first, because this extract can lower blood sugar on its own.

Otherwise, it's generally well tolerated for short-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Max, straight from the product label.

Brand Good State
Barcode (UPC) 857515003350
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276980
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Max by Good State, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
120
UPC/BARCODE
857515003350
IngredientAmount% DV
Cissus quadrangularis extract650 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cissus quadranglularis, a perennial plant of the grape family, can be used to promote and maintain healthy joints. It can also promote a healthy cortisol level, and support weight loss. Cissus is rich in vitamin C and antioxidants.

General Statements

Gives your joints support at times when you need it the most.

100% satisfaction guaranteed

Sport line Professional grade

Results will vary.

Text Support: +1-215-608-1124 X000E12PWH FBA USA

Precautions

Note: If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 21 or are taking medications, consult your health care practitioner before using this product.

Discontinue use and consult your doctor if any adverse reactions occur.

Caution: Keep out of reach of children.

Always speak with your physician before using any dietary supplement.

Note: If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 21 or are taking medications, consult your health care practitioner before using this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Give your body what it needs! Good State Health Solutions

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults as a dietary supplement take 2 capsules 10 minutes before breakfast and 2 capsules 10 minutes before dinner. Do not take before bed. Cissus max should be taken for at least 30 days minimum to feel its effects.

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Max by Good State label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Max label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Max by Good State

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Cissus quadrangularis extract

Interacts with
86 drugs
650 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis extract monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Max by Good State Drug Interactions

Want to check YOUR meds against Cissus Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis extract 86

Individual Drug Interactions

The ingredients in Cissus Max interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Max interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Max with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Max, from the product label.

Good State

Name
GoodState, Inc.
Street Address
575 Virginia Drive, Suite C
City
Fort Washington
State
PA
ZipCode
19034
Phone Number
1-866-227-6097
Web Address
www.GoodState.com
Pharmacist Counseling Corner

Cissus Max by Good State: Common Questions

Does Cissus Max by Good State interact with any medications?
Yes. Based on its ingredients, Cissus Max has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Max contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Cissus quadrangularis actually do?
Research suggests it may help with weight management. For other uses like bone health, cholesterol, or cancer prevention, the evidence isn't solid enough for us to say whether it works.
Can I take this if I'm pregnant or breastfeeding?
No, there isn't enough safety data. Both pregnancy and breastfeeding are times to avoid it. Talk with your doctor or pharmacist about alternatives if you need support during these periods.
Does this supplement have fillers?
It contains cellulose, which is an inactive ingredient used as a filler in the capsule. If you're trying to avoid fillers entirely, this may not be the right choice for you.
What side effects does Cissus quadrangularis cause?
Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported. However, these occurred at the same rate or lower than placebo in studies, so they're not common.
Is it safe to take long-term?
It's been studied safely in the short term, but long-term safety data is limited. If you plan to use it regularly for months on end, discuss that with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Max is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Max label
Go deeper

The Full Monographs Behind Cissus Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team