Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Cissus Quadrangularis Extract Ingredients & Drug Interactions

by Herbadiet

Cissus Quadrangularis Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cissus Quadrangularis Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis Extract by Herbadiet — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Cissus Quadrangularis Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Herbadiet's Cissus Quadrangularis Extract is a single-ingredient powder: Cissus quadrangularis extract. The extract is derived from a tropical vine and contains compounds thought to affect blood glucose and fat metabolism.

There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heal broken bones.
  • We looked for evidence on: Fractures, Bone fracture recovery, Fracture healing, Bone healing.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures (Natural Medicines).

The evidence for Cissus quadrangularis breaks down like this: it's rated possibly effective for obesity, based on small clinical studies showing it may help reduce fasting blood glucose in people who are overweight or obese. For hyperlipidemia (high cholesterol), osteopenia (low bone density), cancer, and epilepsy, the evidence isn't established — we have insufficient reliable data to rate it either way.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis extract is generally well tolerated in short-term use, but long-term safety hasn't been well studied. Headache and insomnia have been reported, as have flatulence, diarrhea, gastritis, and dry mouth — however, these side effects occurred at rates similar to or lower than placebo in trials.

There isn't enough safety data to recommend it during pregnancy or while breastfeeding; talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — insulin, metformin, sulfonylureas, or any other type — double-check with your doctor or pharmacist before using this product. The extract may lower blood sugar further and increase your risk of hypoglycemia.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with weight and blood glucose management if the small-study evidence holds for you, but it's a single-ingredient extract with limited long-term data. If you take diabetes medication, you'll need to clear it with your doctor or pharmacist first because of the risk of low blood sugar.

Have that conversation before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis Extract, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244344
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
400 mg
Maximum serving Sizes:
800 mg
IngredientAmount% DV
Cissus quadrangularis extract powder400 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Heal Broken Bones

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

V Vegan

Ethically Sourced Scientifically Tested Premium Grade Ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 800mg daily, or as directed by physician.

Precautions

Keep out of reach of children.

Warning: Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No. ARK-P27

Formula

Standardized Extract Powder Derived from Cissus Quadrangularis Stems

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size400 mg Dosage formPowder Amounts shown are per serving.

Cissus quadrangularis extract powder

Interacts with
86 drugs
400 mg per serving Form: Total Ketosteroids

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis extract powder monograph & interactions
Interaction report

Cissus Quadrangularis Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis extract powder 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis Extract interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis Extract interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis extract powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis extract powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis extract powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Cissus Quadrangularis Extract by Herbadiet: Common Questions

Does Cissus Quadrangularis Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis Extract has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on diabetes medication?
Not without checking first with your doctor or pharmacist. Cissus quadrangularis may lower blood glucose on its own, so combining it with diabetes drugs could push your blood sugar too low. Your healthcare provider can tell you whether it's safe for you and whether your medication dose needs adjusting.
Is it safe to use during pregnancy or breastfeeding?
There isn't enough safety data to know either way. The safety data advises against using it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about your individual situation.
What side effects should I expect?
Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported — but in the studies, these occurred at rates similar to or lower than placebo. Most people don't experience them.
Does this actually work for weight loss?
It's rated possibly effective for obesity based on small clinical studies showing it may lower fasting blood glucose in people who are overweight or obese. That said, the evidence is limited and more research would help.
Is there any data on using it long-term?
Long-term safety hasn't been well studied. The extract is generally well tolerated in short-term use, but we don't have solid information about what happens if you take it for months or years.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis Extract label
Go deeper

The Full Monographs Behind Cissus Quadrangularis Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team