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Dietary supplement

Cissus Quadrangularis Ingredients & Drug Interactions

by NutraBio

Cissus Quadrangularis label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis by NutraBio — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus Quadrangularis by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus aerial parts extract, made from the above-ground parts of the Cissus quadrangularis plant. The capsule itself is made from hypromellose (a plant-based capsule material) and water — that's it for inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports joint health.
  • We looked for evidence on: Joint pain, Osteoporosis, Osteopenia, Rheumatoid arthritis (RA), Fractures, Cartilage support — and 2 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain, Rheumatoid arthritis (RA).

Cissus Quadrangularis is possibly effective for weight loss and obesity. Small clinical trials suggest it may help reduce fasting blood glucose in people who are overweight or obese.

For high cholesterol (hyperlipidemia), bone loss (osteopenia), cancer, and epilepsy, the evidence isn't established in our data — we don't have enough reliable information to rate it for those uses.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus is generally well tolerated in short-term use, though long-term safety hasn't been thoroughly studied. In clinical trials, headache and insomnia were reported, but at rates the same as or lower than placebo.

Some people also reported flatulence, diarrhea, stomach inflammation (gastritis), and dry mouth — again, at rates similar to placebo. There isn't enough safety data to recommend Cissus during pregnancy or while breastfeeding.

If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before starting it.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (including insulin or any medication to lower blood sugar), check with your pharmacist or doctor before adding Cissus — there's a Moderate risk of blood sugar dropping too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus may help with weight loss, but it can lower blood sugar — so it's not for anyone taking diabetes medications without a conversation first. It's generally well tolerated short-term.

Check your exact medications before you start, especially if you manage blood sugar.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908218164
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 329358
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
649908218164
IngredientAmount% DV
Cissus Aerial Parts Extract1200 mg--

Other ingredients: Hypromellose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules (1 serving) daily with 8-12 ounces of water.

Precautions

Warning: Keep out of reach of children. Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician before use if you have a medical condition or are taking any medication.

Discontinue use two weeks prior to surgery.

Processed in a facility that also processes milk and tree nuts.

General Statements

"We let our business E.T.H.I.C's be our guide." Mark Glazier President & CEO

Wellness

Seals/Symbols

Manufactured in our GMP & FDA Inspected Facility Made in USA with ingredients sourced worldwide

OU (Kosher)

Formulation

Supports joint health

Made without gluten, lactose and GMO's.

Vegetarian

NB Ethics Efficacy | Transparency | Honesty | Innovation | Commitment

Formula

Standardized to 40% ketosterones

OU (Kosher)

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Cissus Aerial Parts Extract

Interacts with
86 drugs
1200 mg per serving Form: Cissus quadrangularis Aerial Parts Extract

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis by NutraBio Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus Aerial Parts Extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis interact with drugs. Each result below shows which ingredient is responsible. Cissus Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus Aerial Parts Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Pharmacist Counseling Corner

Cissus Quadrangularis by NutraBio: Common Questions

Does Cissus Quadrangularis by NutraBio interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cissus if I'm on diabetes medication?
Not without checking first. Cissus may lower blood sugar, and taking it with antidiabetes drugs carries a Moderate risk of blood sugar dropping too low. Talk to your pharmacist or doctor — they may need to adjust your medication dose or monitor your blood sugar more closely.
Does Cissus actually help with weight loss?
It's possibly effective. Small clinical studies suggest Cissus can help reduce fasting blood glucose in people who are overweight or obese, which may support weight management. But the evidence is limited to those studies.
What are the side effects?
Headache and insomnia were reported in trials, along with flatulence, diarrhea, stomach inflammation, and dry mouth. The good news is these side effects occurred at rates the same as or lower than placebo — so they're not common.
Can I take Cissus while pregnant or breastfeeding?
There isn't enough safety data, so it's best avoided during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist for personalized advice.
How long is it safe to take Cissus?
The data we have shows it's generally well tolerated in short-term use, but long-term safety hasn't been well studied. If you're thinking of taking it long-term, mention that to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis label
Go deeper

The Full Monographs Behind Cissus Quadrangularis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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