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Dietary supplement

Cissus Quadrangularis 1000 mg Ingredients & Drug Interactions

by Bronson

Cissus Quadrangularis 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis 1000 mg is a dietary supplement by Bronson with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis stem extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis 1000 mg by Bronson

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis 1000 mg by Bronson — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus Quadrangularis 1000 mg by Bronson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: Cissus quadrangularis stem extract at 1000 mg per capsule. The extract comes from a plant traditionally used in several health contexts.

The capsule itself is made from modified cellulose, microcrystalline cellulose, magnesium stearate, and silicon dioxide — these are inactive ingredients that help form and preserve the supplement.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports strong bones and healthy joints.
  • We looked for evidence on: Fractures, Joint pain, Osteopenia, Osteoporosis, bone density, cartilage health — and 1 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain.

Cissus quadrangularis is possibly effective for obesity — small studies suggest it may help with weight management and blood glucose control in people who are overweight. For hyperlipidemia (high cholesterol and triglycerides), osteopenia (low bone density), cancer, and epilepsy, we don't have enough reliable evidence to rate how well it works.

The evidence is most solid for its use in weight management, but it's not a standalone treatment.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been thoroughly studied. Some people have reported headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth in trials — but these side effects occurred at rates similar to or lower than placebo, so they're not common.

The safety data isn't adequate during pregnancy or breastfeeding, so it's best to avoid it in those situations.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes medication, check with your doctor or pharmacist before starting this product. Cissus quadrangularis may lower blood sugar and could increase your risk of hypoglycemia when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're managing weight and want to try an herbal supplement with some clinical support, this may be worth considering — but talk it over with your doctor first, especially if you take diabetes medication. The long-term safety profile isn't well established, so it's not a forever supplement without checking in.

Your doctor or pharmacist can help you weigh whether it fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis 1000 mg, straight from the product label.

Brand Bronson
Barcode (UPC) X002FL2FQP
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232974
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis 1000 mg by Bronson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X002FL2FQP
IngredientAmount% DV
Cissus quadrangularis stem extract1000 mg--

Other ingredients: modified Cellulose capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Lab Tested Made from High Quality Ingredients GMP Good Manufacturing Practice

General Statements

365 day 100% money back guaranteed Nutrition Questions or Comments? Support @bronsonlabs.com Call 1-800-235-3200 Mon. - Fri. 7 AM - 6 PM MST Sat. 8 AM - 4:30 PM MST New Bronson Nutrition+ since 1960

Formula

Standardized herb

Formulation

Supports strong bones and healthy joints Helps maintain healthy cortisol levels

Non-GMO Gluten-free Soy-free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take 2 capsules daily, preferably with a meal, or as directed by a healthcare professional.

Precautions

Warning: Do not take if you are under 18.

Do not take if you are pregnant or nursing. Consult a healthcare professional before taking this product if you have a diagnosed medical condition, are taking medication or planning to undergo laboratory testing.

Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis 1000 mg by Bronson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis 1000 mg by Bronson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cissus quadrangularis stem extract

Interacts with
86 drugs
1000 mg per serving Form: phytosterols

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis stem extract monograph & interactions

Other (inactive) ingredients: Modified Cellulose capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis 1000 mg by Bronson Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis stem extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis 1000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis stem extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis stem extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis stem extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis 1000 mg, from the product label.

Bronson

Name
Bronson Laboratories
Street Address
70 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
1-800-235-3200
Web Address
BronsonVitamins.com
Pharmacist Counseling Corner

Cissus Quadrangularis 1000 mg by Bronson: Common Questions

Does Cissus Quadrangularis 1000 mg by Bronson interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis 1000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way. It's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might I notice?
Some people report headache, insomnia, flatulence, diarrhea, gastritis, or dry mouth. In clinical trials, these happened at the same rate as placebo or less often, so they're uncommon. If you notice anything bothersome, let your doctor know.
How long is it safe to take this supplement?
It's generally well tolerated in short-term use, but long-term safety hasn't been well studied. Check in with your doctor or pharmacist about how long is right for your situation.
Does this really help with weight loss?
Small studies suggest it may help with weight management and fasting blood glucose in people with overweight or obesity. It's possibly effective for that — but it's not a replacement for diet and exercise, and results vary from person to person.
What is Cissus quadrangularis?
It's a plant extract traditionally used in herbal medicine. The supplement uses the stem extract, which small studies suggest may support weight management and blood glucose control.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis 1000 mg label
Go deeper

The Full Monographs Behind Cissus Quadrangularis 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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