Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Appetite Reducer Fem Ingredients & Drug Interactions

by Body Attack

Appetite Reducer Fem label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Appetite Reducer Fem against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Appetite Reducer Fem is a dietary supplement by Body Attack with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 2,037 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Glucomannan, Calcium, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Appetite Reducer Fem by Body Attack

Ask about any prescription or over-the-counter medication and we check it for interactions with Appetite Reducer Fem by Body Attack — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Appetite Reducer Fem by Body Attack

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Fiber” is listed as a grouped ingredient — the label gives one combined amount (3 Gram(s)) without saying how much of each component you get.

Appetite Reducer Fem contains three active ingredients. Calcium supports bone health and plays roles in nerve and muscle function.

Vitamin B12 is essential for nerve health and energy metabolism. Glucomannan is a soluble fiber derived from the konjac plant, meant to absorb water in your digestive tract and promote fullness.

The product also contains several inactive ingredients—konjac glucomannan, hydroxypropylmethylcellulose, calcium carbonate, and cyanocobalamin—which are fillers and capsule materials that help deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Reduce body weight when dieting.
  • We looked for evidence on: Constipation, Obesity, Weight management, Appetite suppression, Metabolic syndrome.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Calcium is rated "Possibly Ineffective" for Obesity.
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

Calcium is rated effective for kidney failure, heartburn (dyspepsia), low calcium levels (hypocalcemia), high potassium (hyperkalemia), and likely effective for osteoporosis. Vitamin B12 is rated effective for a rare genetic condition affecting B12 absorption (Imerslund-Grasbeck disease), B12 deficiency itself, and likely effective for cyanide poisoning; it's rated possibly effective for canker sores and nerve pain after shingles (postherpetic neuralgia).

Glucomannan is rated possibly effective for constipation, type 2 diabetes, and high cholesterol (hyperlipidemia), but evidence is insufficient to rate it for high blood pressure.

The evidence, ingredient by ingredient Calcium Vitamin B12 Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. Common side effects are belching, constipation, diarrhea, bloating, and stomach upset.

Rarely, very high doses raise concerns about kidney stones and a serious calcium-skin condition called calciphylaxis. Some research suggests high daily calcium intake (over 1500 mg) may link to advanced prostate cancer risk, though findings are mixed.

There's also concern about a possible link between high calcium intake and heart disease, though this remains debated. Vitamin B12 is very well tolerated and has no established upper limit; excess is cleared by your kidneys.

Rarely, it can cause allergic reactions like rash or hives, especially in people with a cobalt allergy. Extremely rare cases of severe low potassium (hypokalemia) have been reported when correcting a B12-related anemia.

Glucomannan is generally well tolerated with plenty of water, but common side effects include bloating, constipation, diarrhea, nausea, and gas. Serious but rare risks are choking and intestinal blockage, especially if taken dry or as a tablet without enough fluid.

Side effects, ingredient by ingredient Calcium Vitamin B12 Glucomannan

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Glucomannan, Calcium, Vitamin B12.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,038 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on HIV medications (dolutegravir, elvitegravir, raltegravir), the antibiotic ceftriaxone, blood pressure or heart drugs (diltiazem, sotalol), thyroid hormone (levothyroxine), diabetes medication (metformin or glyburide), the psoriasis cream calcipotriene, or any other oral medications. Calcium's Major interactions with HIV drugs and ceftriaxone, plus Moderate effects on several others, mean timing and spacing matter.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is meant to help with appetite and digestion through fiber and B12 support. If you take HIV medications, thyroid hormone, heart or blood pressure drugs, diabetes medication, or the antibiotic ceftriaxone, talk with your pharmacist before starting—calcium and other ingredients here may reduce how well those drugs work or create unsafe combinations.

Drink plenty of water with this product to avoid blockage. If you're pregnant or breastfeeding, check with your provider first, especially about glucomannan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Appetite Reducer Fem, straight from the product label.

Brand Body Attack
Barcode (UPC) 4250350546567
Net contents 60 Vegan Cap(s); 43 Gram(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 329527
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Appetite Reducer Fem by Body Attack, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
10
UPC/BARCODE
4250350546567
IngredientAmount% DV
Calcium163 mg20%
Vitamin B127.5 mcg300%
Fiber3 Gram(s)--
Glucomannan3 Gram(s)--

Other ingredients: Konjac Glucomannan, Hydroxypropylmethylcellulose, Calcium Carbonate, Cyanocobalamin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Appetite Reducer FEM from Body Attack contains glucomannane, a water-soluble dietary fibre derived from the root of the konjac plant. Taken daily, 3 g glucomannane may help reduce body weight when dieting.

Nutrients: 3000 mg glucomannane per serving plus vitamin B12

Nutritional supplement with dietary fibre from konjac root (glucomannane), calcium and vitamin B12.

Suggested/Recommended/Usage/Directions

Taken daily, 3 g glucomannane may help reduce body weight when dieting. Recommended dosage: To benefit from it, take 3 x 2 capsules with plenty of water (300 mL) approximately 30 minutes before main meals.

Note: The capsules should be taken with plenty of water so that the glucomannane safely reaches the stomach.

Precautions

Do not exceed the recommended daily dosage.

Individuals with dysphagia should pay particular attention to an ample water supply.

Not suitable for pregnant, nursing women and children.

Not suitable for pregnant, nursing women and children.

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Keep out of reach of small children.

Formulation

Suitable for overweight individuals.

For natural & healthy weight loss For weight reduction relates to the daily intake of at least 3 g of glucomannane in conjunction with a low-calorie diet

Storage

If kept unopened in a cool, dry place, best before end of/Lot no.: see bottom. Once opened, use up quickly. Keep away from direct heat and light.

General Statements

NRV NRV = % of Nutrient Reference Values

60 capsules (714 mg each)

Seals/Symbols

Made in Germany

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Appetite Reducer Fem by Body Attack label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Appetite Reducer Fem label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Appetite Reducer Fem by Body Attack

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
163 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Vitamin B12

Interacts with
20 drugs
7.5 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Fiber

3 Gram(s) per serving

Other (inactive) ingredients: Konjac Glucomannan, Hydroxypropylmethylcellulose, Calcium Carbonate, Cyanocobalamin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Appetite Reducer Fem by Body Attack Drug Interactions

Want to check YOUR meds against Appetite Reducer Fem?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,037Drugs
7 Major 2,030 Moderate

Ingredients driving the most interactions

Glucomannan 2,022
Calcium 168
Vitamin B12 20

Individual Drug Interactions

The ingredients in Appetite Reducer Fem interact with 2,037 drugs. Click any drug to see the details.

3 of the 3 ingredients in Appetite Reducer Fem interact with drugs. Each result below shows which ingredient is responsible. Glucomannan Calcium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Appetite Reducer Fem with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucomannan1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Glucomannan full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Appetite Reducer Fem, from the product label.

Body Attack

See all Body Attack products
Name
Body Attack Sports Nutrition GmbH & Co. KG
Street Address
Schnackenburgalle 217-223
City
Hamburg
ZipCode
22525
Web Address
www.body-attack.com
Pharmacist Counseling Corner

Appetite Reducer Fem by Body Attack: Common Questions

Does Appetite Reducer Fem by Body Attack interact with any medications?
Yes. Based on its ingredients, Appetite Reducer Fem has a known interaction with 2,037 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Appetite Reducer Fem contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on levothyroxine for my thyroid?
Not without spacing them apart. Calcium in this product reduces how much levothyroxine your body absorbs. Take your levothyroxine and this product at least 4 hours apart, and mention it to your pharmacist so they can double-check your thyroid levels over time.
What if I'm taking metformin for diabetes?
Metformin can lower your B12 over time, and this product has B12 in it, which is helpful. But the glucomannan fiber here may also reduce how well your metformin gets absorbed. Space out your doses—take metformin and this product a couple of hours apart—and let your pharmacist know.
Will this help me lose weight or feel less hungry?
The product contains glucomannan, a fiber that absorbs water and may promote fullness, and it's rated possibly effective for appetite control through that mechanism. Results vary from person to person, and fiber works best when you drink plenty of water.
Is it safe to take during pregnancy?
Calcium is safe in recommended amounts during pregnancy. Vitamin B12 is also safe and needed then. But there isn't enough reliable safety data on glucomannan in pregnancy, so talk with your doctor before starting this product.
What are the most common side effects?
The fiber can cause bloating, gas, constipation, or diarrhea—especially in higher doses without enough water. Calcium may cause belching, constipation, or stomach upset. Taking it with plenty of water helps reduce these. Serious side effects like intestinal blockage are rare but possible if you don't drink enough liquid.
Can I take this with my other supplements or medications?
That depends on what else you're taking. This product has interactions with quite a few medications, especially HIV drugs, thyroid hormone, heart medications, and some antibiotics. Use the interaction checker on this page with your full medication list, or ask your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Appetite Reducer Fem label
Go deeper

The Full Monographs Behind Appetite Reducer Fem’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

Appetite Reducer Fem's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 107 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
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Vitamin B12 30 references
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Glucomannan 15 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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