Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Blood Pressure Take Care Ingredients & Drug Interactions

by New Chapter

Blood Pressure Take Care label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blood Pressure Take Care against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blood Pressure Take Care is a dietary supplement by New Chapter with 4 active ingredients. Its ingredients are commonly taken for antioxidant support, heart and circulation health, vein problems (such as varicose veins).Based on those ingredients, 1,107 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape (Vitis vinifera) (seed) aqueous extract, organic Maitake, Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blood Pressure Take Care by New Chapter

Ask about any prescription or over-the-counter medication and we check it for interactions with Blood Pressure Take Care by New Chapter — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blood Pressure Take Care by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Blood Pressure Take Care contains four active ingredients, each derived from plants or mushrooms. Grape seed aqueous extract, maitake mushroom, holy basil leaf extract, and black currant fruit extract make up the formula.

These are delivered in capsule form with hypromellose and minor inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain healthy blood pressure levels.
  • We looked for evidence on: Hypertension, Cardiovascular disease (CVD), Atherosclerosis, Hypercholesterolemia, Hyperlipidemia, Metabolic syndrome — and 4 related terms.
  • The strongest evidence on file: Grape is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hypercholesterolemia, Hypertension, and more.
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The evidence supporting this product is limited. Grape seed extract is rated possibly effective for chronic venous insufficiency (a condition involving poor blood flow in the legs), but the other ingredients lack established effectiveness in our data.

Maitake mushroom, holy basil, and black currant have insufficient reliable evidence for the conditions they're studied in — meaning we don't yet know whether they work for those purposes. None of the ingredients has evidence strong enough to claim the product will lower your blood pressure.

The evidence, ingredient by ingredient Grape Maitake Mushroom Holy Basil Black Currant

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Grape seed extract is generally well tolerated, though some people report abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. A rare case of anaphylaxis to grape skin has been reported.

Maitake mushroom is generally well tolerated as food and in supplements, with the most common side effect being gastrointestinal discomfort — diarrhea and stomach pain. Holy basil extract is generally well tolerated short-term in adults, with loose stools and nausea reported most often.

Black currant seed oil caused mild diarrhea in a small number of study participants. For pregnancy and breastfeeding: grape seed extract is rated likely safe.

Maitake mushroom and holy basil should be avoided during pregnancy and breastfeeding due to insufficient safety data. Black currant berry is safe as food, but safety data on the concentrated supplement during pregnancy and breastfeeding are lacking — speak with your doctor or pharmacist for personalized advice if you're pregnant or nursing and considering this product.

Side effects, ingredient by ingredient Grape Maitake Mushroom Holy Basil Black Currant

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Grape, Maitake Mushroom, Black Currant, Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,108 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Blood Pressure Take Care, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (including warfarin) — all four ingredients carry a moderate risk of increased bleeding. Also confirm your use if you're on antidiabetes drugs or antihypertensive (blood pressure) medications, as maitake and holy basil may amplify their effects.

If you take cyclosporine, midazolam, pentobarbital, or any medication processed by your liver's CYP enzymes, ask your pharmacist or doctor before adding this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Blood Pressure Take Care may appeal to you if you're looking for herbal support for circulation, but the evidence that it actually lowers blood pressure isn't established in the data we hold. If you take any prescription medications — especially blood thinners, diabetes drugs, blood pressure medications, warfarin, cyclosporine, midazolam, pentobarbital, or drugs processed by your liver's CYP enzymes — you'll need to check with your doctor or pharmacist before starting this product.

The ingredient list creates a meaningful interaction risk across over 1,000 medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blood Pressure Take Care, straight from the product label.

Brand New Chapter
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 82692
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blood Pressure Take Care by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Grape (Vitis vinifera) (seed) aqueous extract300 mg--
organic Maitake150 mg--
Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract50 mg--
Black Currant (Ribes nigrum) (fruit) extract25 mg--

Other ingredients: Hypromellose, Contains Less Than 2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Focus On Your Blood Pressure

Healthy blood pressure is influenced by many different functions. Blood Pressure Take Care targets multiple pathways to maintain blood pressure already within normal levels.

The herbs in Blood Pressure Take Care have been carefully selected and combined, in the traditional method, to deliver a synergistic herbal blend for men and women. Our gentle, full-spectrum process preserves nature's full complexity, delivering a super-pure, super-potent herbal extract.

Not a replacement for blood-pressure lowering drugs.

Please recycle this bottle after use.

Supports healthy blood vessel function Retains healthy blood pressure levels Modulates important metabolic functions

Get the whole truth! Sign up for our e-newsletter at newchapter.com/newsletter

Brand IP Statement(s)

Blood Pressure Take Care delivers an effective and clinically studied natural extract combined with additional cardio-supportives for comprehensive blood pressure support.

2016 New Chapter, Inc.

2016 New Chapter, Inc.

Formula

Targeted Holy Basil, Maitake mushroom and Black Currant work together to help maintain healthy blood vessel function.

Precautions

Caution: As with any dietary supplement, you should advise your healthcare professional of the use of this product.

Ask a healthcare professional before use if you have a medical condition, are taking any regular medication or have a surgery planned. If you are nursing, pregnant, or considering pregnancy, you should consult your healthcare professional prior to using this product.

Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction. Do not exceed suggested use.

Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction.

Keep out of reach of children.

Not recommended for use in children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

0401-C01

Formulation

Non-GMO verified formula

Naturally gluten free. 100% Vegetarian; No artificial flavors or colors.

100% Vegetarian; No artificial flavors or colors.

Seals/Symbols

Non GMO Project Verified

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule daily with food.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blood Pressure Take Care by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blood Pressure Take Care label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blood Pressure Take Care by New Chapter

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Grape (Vitis vinifera) (seed) aqueous extract

Interacts with
910 drugs
300 mg per serving

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape (Vitis vinifera) (seed) aqueous extract monograph & interactions

Organic Maitake

Interacts with
260 drugs
150 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Organic Maitake monograph & interactions

Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract

Interacts with
212 drugs
50 mg per serving

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract monograph & interactions

Black Currant (Ribes nigrum) (fruit) extract

Interacts with
140 drugs
25 mg per serving

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjo...

Black Currant (Ribes nigrum) (fruit) extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Contains Less Than 2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blood Pressure Take Care by New Chapter Drug Interactions

Want to check YOUR meds against Blood Pressure Take Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,107Drugs
1,085 Moderate 22 Minor

Ingredients driving the most interactions

Grape (Vitis vinifera) (seed) aqueous extract 910
organic Maitake 260
Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract 212
Black Currant (Ribes nigrum) (fruit) extract 140

Individual Drug Interactions

The ingredients in Blood Pressure Take Care interact with 1,107 drugs. Click any drug to see the details.

4 of the 4 ingredients in Blood Pressure Take Care interact with drugs. Each result below shows which ingredient is responsible. Grape (Vitis vinifera) (seed) aqueous extract organic Maitake Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract Black Currant (Ribes nigrum) (fruit) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Blood Pressure Take Care with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape (Vitis vinifera) (seed) aqueous extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape (Vitis vinifera) (seed) aqueous extract full monograph & interactions

organic Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
organic Maitake full monograph & interactions

Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holy Basil (Ocimum sanctum) (leaf) hydroethanolic extract full monograph & interactions

Black Currant (Ribes nigrum) (fruit) extract2 drug types · 140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.
Gamma-linolenic acid (GLA), a constituent of black currant seed oil, appears to have antiplatelet effects.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures.

Likelihood Possible Evidence D
Black Currant (Ribes nigrum) (fruit) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blood Pressure Take Care, from the product label.

New Chapter

See all New Chapter products
Name
New Chapter, Inc.
Street Address
90 Technology Drive
City
Brattleboro
State
VT
ZipCode
05301
Phone Number
888-874-4461
Web Address
www.newchapter.com/newsletter
Pharmacist Counseling Corner

Blood Pressure Take Care by New Chapter: Common Questions

Does Blood Pressure Take Care by New Chapter interact with any medications?
Yes. Based on its ingredients, Blood Pressure Take Care has a known interaction with 1,107 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blood Pressure Take Care contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually lower blood pressure?
The evidence in our data doesn't establish that it does. Grape seed extract is possibly effective for chronic venous insufficiency (a circulation condition), but the other ingredients have insufficient evidence for the conditions they've been studied in. We can't confirm this product works for blood pressure on its own.
Can I take this if I'm pregnant or breastfeeding?
Grape seed extract is rated likely safe, but maitake mushroom and holy basil should be avoided during pregnancy and breastfeeding due to insufficient safety data. Black currant berry is safe as food, but the concentrated supplement lacks safety information for pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized guidance based on your situation.
What are the most common side effects?
Grape seed extract may cause abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, or nausea. Maitake mushroom most commonly causes diarrhea and stomach pain. Holy basil typically causes loose stools and nausea. Black currant seed oil has been associated with mild diarrhea in some users.
What's in each capsule?
The product contains four active ingredients: grape seed aqueous extract, organic maitake mushroom, holy basil leaf hydroethanolic extract, and black currant fruit extract. The capsules are made with hypromellose and contain less than 2% of other inactive ingredients.
Is this product safe to use long-term?
Grape seed extract and maitake mushroom are generally well tolerated in studies, but high-quality long-term safety data for holy basil are limited. Black currant supplement safety over the long term is less studied than the berry itself. For extended use, discuss this with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blood Pressure Take Care label
Go deeper

The Full Monographs Behind Blood Pressure Take Care’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph → Herb & supplement monograph

Black Currant

Interacts with 140 drugs

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjoyed safely as a food and is popular as a...

Read the full Black Currant monograph →
Sources

Sources & How We Checked

Blood Pressure Take Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
  16. Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constitu
  17. Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. PubMed
  18. Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. PubMed
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Maitake Mushroom 8 references
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Holy Basil 8 references
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See these in context on the Holy Basil monograph →

Black Currant 6 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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