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Dietary supplement

Brahmi Ingredients & Drug Interactions

by Prajna Ayurveda

Brahmi label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brahmi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brahmi is a dietary supplement by Prajna Ayurveda with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 1,192 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Brahmi Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brahmi by Prajna Ayurveda

Ask about any prescription or over-the-counter medication and we check it for interactions with Brahmi by Prajna Ayurveda — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Brahmi by Prajna Ayurveda

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Brahmi Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Brahmi contains two active ingredients, both forms of bacopa: Bacopa monnieri powder and Synapsa (a branded bacopa extract). The product also holds inactive ingredients — hypromellose, cellulose, silica, and stearic acid — which are the capsule material and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bacopa's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: rejuvenating tonic for brain and nervous system.
  • We looked for evidence on: Cognitive function, Cognitive impairment, Generalized anxiety disorder (GAD), Insomnia, Memory, Mental clarity — and 2 related terms.
  • The closest evidence on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD) (Natural Medicines).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Insomnia.

The evidence for bacopa is not established for any of the uses listed in the data we hold. These include Alzheimer disease, cognitive function, cognitive impairment, ADHD, attention problems, sexual dysfunction, and back pain — all show insufficient reliable evidence to rate.

That means the research so far hasn't been strong enough to say whether it works.

The evidence, ingredient by ingredient Gotu Kola Bacopa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacopa is generally well tolerated, but quality and long-term safety data are limited. The most common side effects are gastrointestinal: abdominal cramps, diarrhea, bloating, nausea, and indigestion occur in 12% to 30% of people who take it.

Headache, dry mouth, drowsiness, insomnia, and vivid dreams have also been reported. There isn't enough safety information to recommend bacopa during pregnancy or while breastfeeding.

If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before starting.

Side effects, ingredient by ingredient Gotu Kola Bacopa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacopa.
  • The most serious interaction on file is rated Moderate.
  • For scale: 931 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Brahmi, have a pharmacist check any medications you take that are broken down by liver enzymes CYP1A2, CYP2C9, CYP2C19, or CYP3A4 — many common drugs fall into these categories. Also check if you take cholinergic drugs, anticholinergic drugs, cevimeline (Evoxac), or thyroid hormone.

Use the interaction tool on this page with your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bacopa is used for brain health and cognition, but we don't have strong evidence it works for those purposes yet. If you take medications processed by your liver or any cholinergic drugs, check your full medication list with us first — the interaction risk is real.

Bacopa is generally easy on the stomach for most people, but talk to your pharmacist if you have concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brahmi, straight from the product label.

Brand Prajna Ayurveda
Barcode (UPC) 810047390855
Net contents 56 Vegan Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302883
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brahmi by Prajna Ayurveda, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Capsule(s)
Maximum serving Sizes:
1 Vegan Capsule(s)
Servings per container
56
UPC/BARCODE
810047390855
IngredientAmount% DV
Brahmi Blend500 mg--
Bacopa monnieri, Powder0 NP--
Synapsa0 NP--

Other ingredients: Hypromellose, Cellulose, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Wisdom Transforms Life Om Namo Narayani Vata Pitta Kapha

Almost out? Call 1-800-843-8516 Or visit healthydirection.com

Formulation

Unconditionally guaranteed for purity and labeled potency.

Due to the nature of these ingredients, color variation may occur.

A rejuvenating traditional tonic for the brain & nervous system

GF Gluten free SF Soy free Dairy free

Storage

To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.

Brand IP Statement(s)

Synapsa is a registered trademark of Soho Flordis International Pty Ltd., exclusively licensed in the United States to PLT Health Solutions, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 vegan capsule twice daily with a meal.

Precautions

Precautions: Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brahmi by Prajna Ayurveda label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brahmi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brahmi by Prajna Ayurveda

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container56 Amounts shown are per serving.

Brahmi Blend

Interacts with
579 drugs
500 mg per serving

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Brahmi Blend monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brahmi by Prajna Ayurveda Drug Interactions

Want to check YOUR meds against Brahmi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,192Drugs
1,179 Moderate 13 Minor

Ingredients driving the most interactions

Brahmi Blend 579

Individual Drug Interactions

The ingredients in Brahmi interact with 1,192 drugs. Click any drug to see the details.

1 of the 1 ingredient in Brahmi interact with drugs. Each result below shows which ingredient is responsible. Brahmi Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Brahmi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Brahmi Blend2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Brahmi Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brahmi, from the product label.

Prajna Ayurveda

See all Prajna Ayurveda products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-843-8516
Web Address
www.healthydirections.com
Pharmacist Counseling Corner

Brahmi by Prajna Ayurveda: Common Questions

Does Brahmi by Prajna Ayurveda interact with any medications?
Yes. Based on its ingredients, Brahmi has a known interaction with 1,192 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brahmi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is bacopa, and why is it in this product?
Bacopa (also called Bacopa monnieri) is a plant used in Ayurvedic medicine. This product contains two forms of it — a powder and a branded extract called Synapsa — both meant to support brain function and cognition.
What side effects might I experience?
The most common are gastrointestinal: abdominal cramps, diarrhea, bloating, nausea, and indigestion happen in about 12% to 30% of people. Headache, dry mouth, drowsiness, insomnia, and vivid dreams have also been reported. Most people tolerate it well overall.
Does bacopa actually improve memory or brain function?
The evidence we hold shows insufficient reliable evidence for bacopa to rate it effective for Alzheimer disease, cognitive impairment, cognitive function, ADHD, sexual dysfunction, or back pain. More research is needed.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information. It's best to avoid Brahmi during pregnancy and while breastfeeding. Talk to your pharmacist or doctor for personalized advice if you're in either situation.
Why do I need to check my medications with a pharmacist?
Bacopa can affect how your liver clears many common medications, potentially raising their levels and side effects. It also interacts with cholinergic and anticholinergic drugs. Your pharmacist can tell you if any of yours are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brahmi label
Go deeper

The Full Monographs Behind Brahmi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph → Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph →
Sources

Sources & How We Checked

Brahmi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
  9. Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
  10. Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
  11. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
  12. Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.

See these in context on the Bacopa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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