Interactions on record — worth a quick check against your medications. Based on 2 of 9 ingredients. Check your meds →
Dietary supplement

Cholox Complete Ingredients & Drug Interactions

by ProCaps Laboratories

Cholox Complete label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cholox Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cholox Complete is a dietary supplement by ProCaps Laboratories with 9 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 764 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cholox Complete by ProCaps Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Cholox Complete by ProCaps Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cholox Complete by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 10 of its 12 active ingredients.
  • “Tocopherols” is listed as a grouped ingredient — the label gives one combined amount (106 mg) without saying how much of each component you get.
  • “Vitamin E” is listed as a grouped ingredient — the label gives one combined amount (462 mg) without saying how much of each component you get.
  • “Fish Oil/Flaxseed Oil” is listed as a grouped ingredient — the label gives one combined amount (685 mg) without saying how much of each component you get.

Cholox Complete is a 12-ingredient supplement built around omega-3 fatty acids and vitamin E. The product includes three omega-3 sources — eicosapentaenoic acid, docosahexaenoic acid, and alpha-linolenic acid — along with a blend of vitamin E forms (alpha-, beta-, gamma-, and delta-tocopherol).

It also contains a proprietary sterol blend, psyllium powder, fish oil and flaxseed oil, phosphatidyl choline, other phospholipids, and peppermint-spearmint oil. The inactive ingredients are gelatin, vegetable magnesium stearate, vegetable stearine, silicon dioxide, and the soft-gelatin capsule itself.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Vitamin E's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: lower total and LDL cholesterol.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, Atherosclerosis, Cardiovascular disease (CVD), Coronary artery bypass graft (CABG) surgery, Angina — and 4 related terms.
  • The closest evidence on file: Vitamin E is rated "Possibly Ineffective" for Angina (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Atherosclerosis, Congestive heart failure (CHF).
  • Also on file: Vitamin E is rated "Likely Ineffective" for Cardiovascular disease (CVD).

The vitamin E in this product is rated Effective for vitamin E deficiency and ataxia with vitamin E deficiency (AVED) — a rare genetic condition. It's rated Possibly Effective for Alzheimer disease, beta-thalassemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and intracranial hemorrhage.

We don't hold effectiveness data for the omega-3 fatty acids or other ingredients in this product, so we can't speak to whether they work for any particular condition.

The evidence, ingredient by ingredient Vitamin E Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E at usual dietary amounts is generally well tolerated. However, the data advises caution with high-dose long-term supplementation — it may raise the risk of bleeding and other harms.

In rare cases, high-dose vitamin E has been linked to bleeding, stroke, and cardiovascular complications. There's also some concern about an increased risk of hemorrhagic stroke with long-term high-dose synthetic vitamin E, though other studies haven't consistently shown this.

If you're pregnant, the safety data rates vitamin E as Possibly Safe from foods and prenatal vitamins, but it advises against high-dose supplements unless your doctor directs it. While breastfeeding, amounts from food and prenatal vitamins are appropriate, but the data advises checking with your doctor before taking high-dose supplements.

We don't hold pregnancy or breastfeeding safety data for the omega-3 ingredients, sterol blend, psyllium, peppermint oil, or phospholipids in this product.

Side effects, ingredient by ingredient Vitamin E Phosphatidylcholine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 765 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Cholox Complete, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — vitamin E raises bleeding risk. Also check if you're on chemotherapy drugs, immunosuppressants like cyclosporine, medications your liver breaks down (CYP3A4 substrates), selumetinib, or niacin.

No interactions are documented for the omega-3 fatty acids, sterol blend, psyllium, peppermint oil, or phospholipids we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cholox Complete is a multi-ingredient formula that may help with omega-3 intake and provides vitamin E forms with established uses for certain vitamin E deficiency conditions. If you take any blood thinners, chemotherapy drugs, immunosuppressants, niacin, or medications your liver breaks down, talk to your pharmacist before starting — vitamin E interacts with quite a few drug types.

If you're pregnant, breastfeeding, or at high risk for bleeding, that's another conversation worth having first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cholox Complete, straight from the product label.

Brand ProCaps Laboratories
Net contents 60 Perma-Fresh(TM) Packet(s); 420 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4689
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cholox Complete by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Packet(s)
Maximum serving Sizes:
1 Packet(s)
Servings per container
30
IngredientAmount% DV
Eicosapentaenoic Acid160 mg--
Docosahexaenoic Acid160 mg--
Total Omega-3 Fatty Acids400 mg--
Beta-Tocopherol0 NP--
Gamma-Tocopherol267 mg--
Alpha-Linolenic Acid80 mg--
Alpha-Tocopherol89 mg443%
Tocopherols106 mg--
Delta-Tocopherol0 NP--
Vitamin E462 mg--
CHoLOX(TM) Proprietary Sterol Blend2 g--
Fibermucil(TM) Psyllium, powder3 g--
Fish Oil/Flaxseed Oil685 mg--
Phosphatidyl Choline140 mg--
other Phospholipids32 mg--
Peppermint-Spearmint, oil10 mg--

Other ingredients: Gelatin, Vegetable Magnesium Stearate, Vegetable Stearine, Silicon Dioxide, Soft-gelatin capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

CHoLOX(TM) complete is specifically formulated to lower Total and LDL Cholesterol. It is based upon decades of extensive clinical studies, which have proven its ability to support heart health by safely reducing Total Cholesterol and LDL (Low Density Lipoprotein) Cholesterol levels. In fact, the research is so convincing and the formula so safe that the active ingredient in CHoLOX complete is approved by the US Food and Drug Administration (FDA) to lower your Total and LDL Cholesterol levels. Our Total and LDL Cholesterol (bad cholesterol) levels are important indicators of heart disease – modern society’s number one killer and not surprisingly, the latest cholesterol-lowering drugs – Statin drugs – have rapidly become the most prescribed drugs in America – and the World. Drugs such as Lipitor,(R) Zocor,(R) Crestor,(R) Pravachol,(R) Vytorin,(TM) Mevacor(R) and Lescol,(R) although extremely effective, come with a long list of undesirable side effects. If you and your physician would like some help achieving healthy cholesterol levels, then CHoLOX is a perfect partner to the Statin drugs to help reduce the dosage (or even the need) for the cholesterol-lowering medicine your doctor may prescribe. As with any drug, if you reduce the dosage you significantly reduce the risk of side effects, but of course you must partner with your physician to determine how CHoLOX can best support your physician’s treatment and dietary recommendations. CHoLOX complete is not a drug and has no side effects. CHoLOX complete provides a 100% safe and natural means for lowering Total and LDL Cholesterol. The Western diet tends to increase our cholesterol levels and clinical studies have consistently proven that including CHoLOX complete’s FDA-approved active ingredient in your diet helps to lower Total and LDL Cholesterol levels. This provides you with a safe and easy way to help reduce your risk of heart disease. In fact, according to the US Food and Drug Administration, consuming at least 400 mg per serving of the active ingredient in CHoLOX complete twice daily with meals for a daily total intake of at least 800 mg, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One packet of CHoLOX complete provides 1,000 mg of this special, FDA-approved active ingredient. To further enhance the activity and benefits of this formula, CHoLOX complete also contains high levels of Micro-Granulated fiber from Psyllium Husk. Fiber is generally considered the most neglected component in the Western diet and delivers a myriad of health benefits, including boosting the efficiency of the special active ingredient in CHoLOX and thereby helping to support healthy cholesterol levels.

New PERMA-FRESH(TM) PURPLE PACKET

(C) 2009 ProCaps Labs

Seals/Symbols

ProCaps(R) LABORATORIES

Precautions

NOTICE This product contains natural fiber and should be consumed with a full glass of water. If consumed without adequate liquid a high fiber product can cause choking and should not be consumed if you have difficulty swallowing. If you feel unexpected abdominal discomfort when using a fiber product, discontinue its use and consult a physician. As with any grain product, inhaled or ingested Psyllium may cause allergic reactions in some individuals. If you are taking prescription medicine by mouth, do not consume at the same time as any fiber product.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE For best results consume two packets of CHoLOX complete daily – one packet with each of your day’s two principal meals. There is never a need nor any additional benefit from consuming more than three packets daily. CHoLOX is always most effective when taken with meals – ideally 30 minutes before or no more than 60 minutes after eating. CHoLOX works best when combined with a nutritious, high fiber diet that is low in cholesterol, saturated and trans (hydrogenated) fats. For additional guidance consult your health professional or contact us – ProCaps Laboratories at 800.800.1200.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

601460 04.25.09 PC

General Statements

Clinically Proven to Reduce the Risk of Heart Disease

CREATED WITH SOLAR ENERGY

FDA APPROVED CHOLESTEROL MANAGEMENT

Lipitor is a registered trademark of Pfizer, Inc. • Zocor is a registered trademark of Merck & Co., Inc. • Crestor is a registered trademark of the AstraZeneca LP • Pravachol is a registered trademark of Bristol-Myers Squibb • Mevacor is a registered trademark of Merck & Co., Inc. • Lescol is a registered trademark of Novartis • Vytorin is a trademark of Merck/Schering-Plough

NEW PERMA-FRESH PURPLE PACKETS • MOISTURE OXYGEN UV PROTECTION

Safely Lowers Total and LDL Cholesterol

THE PERFECT PACKET. The New Perma-Fresh Purple Packet. The Only Packet Worthy of Our 100% Pure Products. Our new Purple Packet is our most advanced Perma-Fresh Packet, offering you even more perfectly protected product under all conditions. To retain potency, vitamins must be protected from light, moisture and oxygen and the clear packets found with typical vitamins fail miserably to do so. Our newly developed Purple Packets are constructed from multiple layers of specialized materials to safeguard our vitamins from damaging light, moisture and oxygen. For decades, our Perma- Fresh Foil Packet has set the standard for vitamin protection and today, our new Purple Perma-Fresh Packet takes the quality of our products to unimaginable levels, giving your investment in your health the protection it deserves.

UNSURPASSED. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs Manufacturer of CHoLOX

Virtually all vitamins and supplements ignore Mother Nature’s first and most beneficial choice of Vitamin E (Gamma) and only provide one form (Alpha) – usually in its less active synthetic form. Vitamin E’s greatest benefits are as an anti-oxidant and nowhere are these properties better demonstrated than with natural Gamma Tocopherol’s superior ability to protect the cardiovascular system from oxidation. Accordingly, CHoLOX complete provides a naturally, balanced high potency blend of all four naturally-occurring Tocopherols, focusing on Gamma and Alpha Tocopherols. Phosphatidyl Choline (PC): Finally, when addressing cholesterol reduction, it is always important to focus on the liver, which produces the majority of the cholesterol in the body. Also, since the most popular cholesterol-lowering medications – Statins – have a substantial impact on liver function, it is common sense to support the health of the liver. No nutrient is more important to the structure of the liver than Phosphatidyl Choline, which makes up almost two-thirds of the extensive and delicate membrane surface area of the healthy liver. Heart health seems to have become synonymous with lower cholesterol levels and, as a result, millions of Americans are taking cholesterol-lowering medicines. Like any medicine, these drugs come with significant side effects and although very effective, their use should be carefully considered with your physician. Also, it is important to never underestimate the power and long-term benefits of a healthy diet and active lifestyle. By adding CHoLOX complete to such a diet and lifestyle, you and your doctor are assured of getting the very best results from your efforts. Lastly, despite CHoLOX complete’s proven effectiveness, it should never provide an excuse to ignore one’s diet. In fact, CHoLOX complete works best when taken with meals that contain less trans- (hydrogenated) and saturated fat, cholesterol and simple or convertible carbohydrates (potatoes, pasta, rice and bread).

Formula

Optimum heart health requires more than simply controlling cholesterol levels, so CHoLOX complete also includes our Essential Omega-3 Oils, Gamma-Alpha Vitamin E and Phosphatidyl Choline. Essential Omega-3 Oils: Research has consistently shown that diets high in Omega-3 Oils are associated with superior heart health, but unfortunately, the Western diet supplies minimal amounts of these vital Omega-3 Oils. CHoLOX complete provides a pure, balanced blend of the most important Omega-3 Oils; EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid) from Fish Oil, along with Alpha Linolenic Acid from our 70% ALA Flaxseed Oil. Gamma-Alpha Vitamin E: Our special Vitamin E blend is unique in that it delivers high concentrations of the two most important and effective forms of natural Vitamin E (Gamma and Alpha Tocopherol).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cholox Complete by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cholox Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cholox Complete by ProCaps Laboratories

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Packet(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Omega-3 Fatty Acids

400 mg per serving

Vitamin E

Interacts with
764 drugs
462 mg per serving Form: Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

CHoLOX(TM) Proprietary Sterol Blend

2 g per serving

Fibermucil(TM) Psyllium, powder

3 g per serving

Fish Oil/Flaxseed Oil

685 mg per serving Form: Anchovy, Mackerel, Sardine, Tuna
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Alpha-Linolenic Acid

Phosphatidyl Choline

No known
interactions
140 mg per serving Form: Soy Lecithin Oil

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidyl Choline monograph & interactions
  • › Other Phospholipids

Peppermint-Spearmint, oil

10 mg per serving

Other (inactive) ingredients: Gelatin, Vegetable Magnesium Stearate, Vegetable Stearine, Silicon Dioxide, Soft-gelatin capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cholox Complete by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against Cholox Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
764Drugs
763 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764

Individual Drug Interactions

The ingredients in Cholox Complete interact with 764 drugs. Click any drug to see the details.

1 of the 9 ingredients in Cholox Complete interact with drugs. Each result below shows which ingredient is responsible. Vitamin E

Each ingredient & the kinds of drugs it affects

For each ingredient in Cholox Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cholox Complete, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps(R) LABORATORIES
Street Address
430 Parkson Road
City
Henderson
State
NV
ZipCode
89011
Phone Number
800.800.1200
Web Address
www.CHoLOX.com
Pharmacist Counseling Corner

Cholox Complete by ProCaps Laboratories: Common Questions

Does Cholox Complete by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, Cholox Complete has a known interaction with 764 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cholox Complete contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The safety data rates vitamin E as Possibly Safe during pregnancy from food and prenatal vitamins, but it advises against high-dose supplements unless your doctor directs it. We don't have pregnancy safety information on file for the omega-3 ingredients, sterol blend, psyllium, or peppermint oil. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Is it safe to breastfeed while taking this?
Vitamin E in normal dietary amounts is rated Likely Safe while breastfeeding, but the data advises checking with your doctor before taking high-dose vitamin E supplements. We don't hold breastfeeding safety data for the other ingredients. Have a conversation with your pharmacist to make sure it's appropriate for your situation.
What is vitamin E actually for?
In this product, vitamin E is Effective for treating vitamin E deficiency and a rare genetic condition called ataxia with vitamin E deficiency (AVED). It's Possibly Effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage. Most people get enough vitamin E from food, so supplementation is usually for specific deficiency or medical conditions.
Can this cause side effects?
Vitamin E is generally well tolerated. Serious side effects are rare but can include bleeding, hemorrhagic stroke, and cardiovascular problems, especially with long-term high-dose use. There's a particular concern about increased bleeding risk if you're on blood thinners or antiplatelet drugs. We don't have specific adverse-effect data for the omega-3s, sterol blend, psyllium, or other ingredients in this product.
What's in this that actually does something?
The vitamin E forms (alpha-, beta-, gamma-, and delta-tocopherol) have documented effectiveness ratings. We don't hold effectiveness data in our records for the omega-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid, alpha-linolenic acid), the proprietary sterol blend, psyllium, peppermint-spearmint oil, or the phospholipids.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cholox Complete label
Go deeper

The Full Monographs Behind Cholox Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph →
Sources

Sources & How We Checked

Cholox Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 79 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
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Phosphatidylcholine 15 references
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See these in context on the Phosphatidylcholine monograph →

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