Classic CBD Oil 25 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Classic CBD Oil 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Classic CBD Oil 25 mg is a dietary supplement by Bluebird Botanicals with 3 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 1,018 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broad-Spectrum Hemp, Distillate, Coconut Oil, Fractionated. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Classic CBD Oil 25 mg by Bluebird Botanicals
Ask about any prescription or over-the-counter medication and we check it for interactions with Classic CBD Oil 25 mg by Bluebird Botanicals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Classic CBD Oil 25 mg by Bluebird Botanicals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 3 active ingredients: fractionated coconut oil (the carrier that makes the oil drinkable), broad-spectrum hemp distillate, and full-spectrum hemp aerial parts extract. Both hemp components deliver cannabinoids and other plant compounds from the hemp plant.
There are no inactive fillers or binders listed.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that any ingredient in this product works for a specific health condition. The hemp extracts here haven't been rated for effectiveness in the research we have on file, and the coconut oil shows insufficient evidence for claims about blood sugar control, cholesterol, or weight.
That doesn't mean the product won't help — it means the science backing those uses isn't solid enough to confirm it one way or the other.
How safe is it?
Well-documented data
Hemp products in food amounts are generally well tolerated, though concentrated extracts like those in supplements are less studied. Rare serious effects from hemp include allergic reactions (ranging from hives to anaphylaxis), and in one case report, a very young child given high-dose hemp extract developed liver problems — but that involved doses much higher than you'd get here.
Coconut is safe in normal food amounts, though concentrated doses are less well studied; if you have a tree nut allergy or sensitivity, coconut can trigger allergic reactions including anaphylaxis. The pregnancy and lactation safety data for the hemp in this product isn't on file, so talk with your doctor or pharmacist if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take estrogen or hormone therapy (Moderate interaction), antihypertensive drugs, ACE inhibitors, blood thinners, antidiabetes medications, or drugs metabolized by CYP1A2 or CYP3A4 enzymes (all Minor interactions). Use the medication search on this page to verify your exact drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take estrogen therapy, blood pressure medications, blood thinners, antidiabetes drugs, or medications processed by your liver's CYP1A2 or CYP3A4 pathways, check with your doctor or pharmacist before starting this product. The hemp and coconut here are generally well tolerated, but because concentrated supplements are less studied than food amounts, having that conversation first is important.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Classic CBD Oil 25 mg, straight from the product label.
| Brand | Bluebird Botanicals |
|---|---|
| Barcode (UPC) | 856888005282 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 309206 |
| Product type | Botanical With Nutrients |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Classic CBD Oil 25 mg by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 470 mg | -- |
| Coconut Oil, Fractionated | 0 NP | -- |
| Broad-Spectrum Hemp, Distillate | 0 NP | -- |
| Full-Spectrum Hemp Aerial Parts Extract | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Full-spectrum hemp extract & coconut oil (MCT) CBD: 25 mg per serving CBD: 1500 mg per bottle
Non-synthetic cannabinoids derived from USA-grown hemp.
Total THC less than or equal to 114 mg per container Total THC less than or equal to 0.95 mg per serving
FDA Statement of Identity
Hemp Supplement
FDA Disclaimer Statement
This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA has not evaluated or approved this product for safety or efficacy.
Precautions
Do not exceed 1 mL (2 servings) per day.
Warning: Do not use if pregnant, nursing, or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.
Warning: Do not use if pregnant, nursing, or under 18 years of age.
This product contains hemp with less than or equal to 0.3% Delta-9-THC on a dry-weight basis. Consumption could result in a failed drug test.
Warning: Consuming this product can expose you to chemicals including Delta-9-THC, which is known to the state of California to cause birth defects or other reproductive harm. See: www.P65Warnings.ca.gov/food.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 serving (15 drops) by mouth, up to twice per day, or as directed by a medical professional.
Storage
Store in a cool, dark place.
Seals/Symbols
US Hemp Authority Certified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Classic CBD Oil 25 mg by Bluebird Botanicals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Classic CBD Oil 25 mg by Bluebird Botanicals
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.5 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Classic CBD Oil 25 mg by Bluebird Botanicals Drug Interactions
HelloPharmacist Interaction Report
Bluebird Botanicals Classic CBD Oil 25 mg contains hemp extracts that interact with a number of medications.
The most serious concern is estrogen therapy — hemp may interfere with how estrogens work in your body, so if you take hormone replacement therapy or birth control, you'll want to run this past your doctor or pharmacist before starting.
Read the full breakdown — every affected drug type, severity by severity
Beyond that, the hemp in this product theoretically affects blood pressure drugs (both general antihypertensives and ACE inhibitors specifically), blood thinners (anticoagulants and antiplatelet drugs), and certain medications your liver processes — specifically those broken down by CYP1A2 and CYP3A4 enzymes. These are all Minor-severity interactions based on animal or test-tube data, not confirmed human studies, but they're real enough to deserve a quick check if you're on any of those medication types.
Coconut oil, the carrier in this product, has a Minor interaction with antidiabetes drugs — theoretically it could increase the risk of low blood sugar (hypoglycemia) — though the evidence comes from animal research.
Altogether, these interactions span 1,019 individual medications. Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Classic CBD Oil 25 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Classic CBD Oil 25 mg interact with 1,018 drugs. Click any drug to see the details.
2 of the 3 ingredients in Classic CBD Oil 25 mg interact with drugs. Each result below shows which ingredient is responsible. Broad-Spectrum Hemp, Distillate Coconut Oil, Fractionated
Bazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Drospirenone, Ethinyl Estradiol interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Classic CBD Oil 25 mg — through 1 ingredient. Tap an ingredient for the detail:
Full-spectrum Hemp Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Full-spectrum Hemp Aerial Parts Extract + Ethinyl Estradiol, Levonogestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Classic CBD Oil 25 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Broad-Spectrum Hemp, Distillate
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Coconut Oil, Fractionated
Antidiabetes Drugs
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.
Brand information
Manufacturer and brand details for Classic CBD Oil 25 mg, from the product label.
Bluebird Botanicals
See all Bluebird Botanicals products- Name
- Bluebird Botanicals
- City
- Louisville
- State
- CO
- ZipCode
- 80027
- Phone Number
- (720) 726-5132
- Web Address
- BluebirdBotanicals.com
Classic CBD Oil 25 mg by Bluebird Botanicals: Common Questions
Does Classic CBD Oil 25 mg by Bluebird Botanicals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What's the difference between the two hemp ingredients in here?
Can I take this if I'm allergic to tree nuts?
Will this affect my blood sugar medication?
Is there any evidence this CBD oil actually works for something?
Are there any fillers or additives in this?
Is it safe to use while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Classic CBD Oil 25 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Classic CBD Oil 25 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Coconut
Interacts with 86 drugsCoconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...
Read the full Coconut monograph → Herb & supplement monographHemp
Interacts with 938 drugsHemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...
Read the full Hemp monograph →Sources & How We Checked
Classic CBD Oil 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 22 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Coconut 10 references
- Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
- Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
- Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
- Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
- Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
- Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
- 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
- Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
- Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
- Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed
Hemp 12 references
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
- Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
- Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
- Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
- Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
- Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
- Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
- Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
- Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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