Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Dong Quai Plus Ingredients & Drug Interactions

by Genestra Brands

Dong Quai Plus label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dong Quai Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Dong Quai Plus is a dietary supplement by Genestra Brands with 2 active ingredients. Its ingredients are commonly taken for menopause symptoms, menstrual cramps and irregular periods, premenstrual syndrome (pms).Based on those ingredients, 163 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dong Quai. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dong Quai Plus by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Dong Quai Plus by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Dong Quai Plus by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Dong Quai Plus contains 2 active ingredients — both forms of dong quai (Angelica sinensis), a traditional Chinese herb used for various conditions. One is the whole herb and the other is a standardized extract, both sourced from the plant's root.

The capsules also contain inactive ingredients: hypromellose, cellulose, and stearic acid, which help form and stabilize the capsule.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: women's menstrual and menopausal health support.
  • We looked for evidence on: Dysmenorrhea, Menopausal symptoms, Premenstrual syndrome (PMS), menstrual cycle regulation, hormone balance.
  • The closest evidence on file: Dong Quai is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms (Natural Medicines).
  • Also on file: Dong Quai is rated "Insufficient Reliable Evidence To Rate" for Premenstrual syndrome (PMS), Dysmenorrhea.

The data we hold shows insufficient reliable evidence to rate dong quai for iron deficiency anemia, osteoporosis, heart disease, migraine headache, or eczema — the conditions listed for this product. That means studies haven't yet established whether it works for these purposes.

If you're considering it for one of these reasons, talk with your doctor about what the current evidence supports.

The evidence, ingredient by ingredient Dong Quai

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Dong quai is generally well tolerated when taken by mouth. The most common side effects are burping and flatulence.

The supplement may increase your bleeding risk and can make your skin more sensitive to sunlight, so use care if you're out in the sun often. Dong quai is rated Possibly Unsafe in pregnancy because it may stimulate the uterus and affect bleeding — avoid it if you're pregnant or trying to become pregnant.

There isn't enough safety data to recommend it while breastfeeding, so talk with your doctor or pharmacist about whether it's right for you in that situation. Dong quai also contains some compounds that have carcinogenic properties in the lab, though it's unknown whether the amounts in this supplement could pose a risk with long-term or high-dose use.

Side effects, ingredient by ingredient Dong Quai

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Dong Quai.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 163 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Dong Quai Plus, check with your doctor or pharmacist if you take warfarin or any other blood thinner (anticoagulants) — the risk of bleeding is Major. Also flag estrogens or hormone replacement therapy and any antiplatelet drugs like aspirin or clopidogrel, where the risk is Moderate.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Dong Quai Plus is mainly a concern if you take blood thinners, aspirin, or hormone therapy — the interactions are real and potentially serious. It's not established to work for the conditions usually listed (anemia, osteoporosis, heart disease, migraines, eczema), and it's not safe in pregnancy or breastfeeding.

Before you start it, run your medications past your own doctor or pharmacist to make sure it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dong Quai Plus, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319613150
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 55991
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dong Quai Plus by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
88319613150
IngredientAmount% DV
Dong Quai250 mg--
Dong Quai (Angelica sinensis) root std. extract150 mg--

Other ingredients: Hypromellose, Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Adult Dose: Take one capsule daily before a meal or as recommended by your healthcare practitioner.

Precautions

Avoid prolonged exposure to sunlight, ultraviolet (UV), or UV therapy.

Risk Information: If you are pregnant; if you have allergy/hypersensitivity to members of the Apiaceae/Umbelliferae family; if you have diarrhea, hemorrhagic diseases or hypermenorrhea/profuse menstrual flow/ heavy periods, do not use.

Risk Information: If you are pregnant; if you have allergy/hypersensitivity to members of the Apiaceae/Umbelliferae family; if you have diarrhea, hemorrhagic diseases or hypermenorrhea/profuse menstrual flow/ heavy periods, do not use.

If menstruation is delayed or absent; or if you experience increased menstrual bleeding time, breast pain, discomfort and/or tenderness, discontinue use and consult your healthcare practitioner.

If you are breastfeeding; or if you have a family history of cancer, consult your healthcare practitioner prior to use.

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Formulation

Guaranteed to contain no added wheat, starch, yeast, gluten, corn, soy, sodium, sugar, artificial coloring or flavoring, antimicrobial preservatives, dairy or animal products.

Ideal for vegans.

The capsules are made from 100% pure vegetable sources, free of preservatives and additives.

Storage

Store in a cool, dry place.

General

V1.0 435

FDA Statement of Identity

HERBAL SUPPLEMENT

Seals/Symbols

Seroyal

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dong Quai Plus by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dong Quai Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dong Quai Plus by Genestra Brands

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dong Quai

Interacts with
163 drugs
250 mg per serving

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scienti...

Dong Quai monograph & interactions

Dong Quai (Angelica sinensis) root std. extract

Interacts with
163 drugs
150 mg per serving Form: Ligustilides

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scienti...

Dong Quai (Angelica sinensis) root std. extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dong Quai Plus by Genestra Brands Drug Interactions

Want to check YOUR meds against Dong Quai Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
163Drugs
2 Major 161 Moderate

Ingredients driving the most interactions

Dong Quai 163

Individual Drug Interactions

The ingredients in Dong Quai Plus interact with 163 drugs. Click any drug to see the details.

1 of the 2 ingredients in Dong Quai Plus interact with drugs. Each result below shows which ingredient is responsible. Dong Quai

Each ingredient & the kinds of drugs it affects

For each ingredient in Dong Quai Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dong Quai3 drug types · 163 drugs

Warfarin (Coumadin)

Dong quai may increase the risk of bleeding when used with warfarin.
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding. In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.

Likelihood Possible Evidence D
Estrogens

Theoretically, dong quai may reduce the effects of estrogens.
Dong quai has estrogenic effects. Theoretically, concomitant use of large amounts of dong quai might interfere with hormone replacement therapy due to competition for estrogen receptors.

Likelihood Possible Evidence D
Dong Quai full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dong Quai Plus, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Dong Quai Plus by Genestra Brands: Common Questions

Does Dong Quai Plus by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Dong Quai Plus has a known interaction with 163 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dong Quai Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Dong Quai Plus if I'm on warfarin?
No — this is a Major interaction. Dong quai can increase warfarin's blood-thinning effects and raise your bleeding risk. Case reports show that INR levels (the measure of how thin your blood is) can rise significantly after a few weeks of use. Do not take this product with warfarin without talking to your doctor first.
What are the most common side effects?
Burping and flatulence are the most common side effects reported when taking dong quai by mouth. It's generally well tolerated overall, but it can increase your sensitivity to sunlight, so be mindful if you spend a lot of time outdoors.
Can I take Dong Quai Plus if I'm pregnant or breastfeeding?
No for pregnancy — the safety data advises against it because dong quai may stimulate the uterus and affect bleeding. For breastfeeding, there isn't enough safety information on file to know either way, so talk with your doctor or pharmacist for personalized advice.
Does Dong Quai Plus actually work for anemia, osteoporosis, or migraines?
The evidence we hold is insufficient to say whether it works for those purposes. Studies haven't yet established whether dong quai is effective for iron deficiency anemia, osteoporosis, heart disease, migraines, or eczema.
Can I take this with aspirin or other blood thinners?
You need to check with your doctor or pharmacist. Dong quai can theoretically increase bleeding risk when combined with antiplatelet drugs like aspirin and with blood thinners other than warfarin — that's a Moderate concern. Your doctor can weigh the risks and benefits for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dong Quai Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dong Quai Plus label
Go deeper

The Full Monographs Behind Dong Quai Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dong Quai

Interacts with 163 drugs

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scientific evidence that it works for these use...

Read the full Dong Quai monograph →
Sources

Sources & How We Checked

Dong Quai Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dong Quai 19 references
  1. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6. PubMed
  2. Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy 1999;19:870-6. PubMed
  3. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  4. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  5. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
  6. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
  7. Shi M, Chang L, He G. [Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus]. Zhongguo Zhong Yao Za Zhi 1995;20:173-5, 192.
  8. Hoult JR, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996;27:713-22.. PubMed
  9. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  10. Chang CJ, Chiu JH, Tseng LM, et al. Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur J Clin Invest 2006;36:588-96. PubMed
  11. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed
  12. Lau CBS, Ho TCY, Chan TWL, Kim SCF. Use of dong quai (Angelica sinensis) to treat peri- and postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause 2005;12:734-40.
  13. Ellis GR, Stephens MR. Untitled (photograph and a brief case report). BMJ 1999;319:650.
  14. Nambiar, S., Schwartz, R. H., and Constantino, A. Hypertension in mother and baby linked to ingestion of Chinese herbal medicine. West J Med 1999;171(3):152.
  15. Lee, S. K., Cho, H. K., Cho, S. H., Kim, S. S., Nahm, D. H., and Park, H. S. Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist. Ann.Allergy Asthma Immunol. 2001;86(4):469-474. PubMed
  16. Xu, J. and Li, G. [Observation on short-term effects of Angelica injection on chronic obstructive pulmonary disease patients with pulmonary hypertension]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(3):187-189.
  17. Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. Am J Health Syst.Pharm 2-15-2002;59(4):339-347. PubMed
  18. Circosta, C., Pasquale, R. D., Palumbo, D. R., Samperi, S., and Occhiuto, F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother.Res. 2006;20(8):665-669.
  19. Fung FY, Wong WH, Ang SK, et al. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017;32:88-96. PubMed

See these in context on the Dong Quai monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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