Fen-Gre Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fen-Gre against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fen-Gre is a dietary supplement by SP Standard Process with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, digestive health and fiber, heart health support.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek, Okra. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fen-Gre by SP Standard Process
Ask about any prescription or over-the-counter medication and we check it for interactions with Fen-Gre by SP Standard Process — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fen-Gre by SP Standard Process
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Fen-Gre contains three active ingredients: rice bran, fenugreek, and okra. Rice bran is a concentrated form of the outer layer of the rice grain.
Fenugreek is a legume seed used traditionally for sexual function, menstrual discomfort, and blood sugar support. Okra is a vegetable sometimes used in supplements for various purposes.
The product is filled in gelatin capsules with water and calcium stearate as inactive binders.
Does it work?
Moderate evidence
Rice bran is possibly effective for abnormal cholesterol and lipid levels (dyslipidemia), though evidence for other uses such as colorectal cancer or hair loss is insufficient or suggests it may be ineffective. Fenugreek is possibly effective for sexual dysfunction, menstrual pain (dysmenorrhea), and type 2 diabetes.
Okra's effectiveness is not established in the data we hold — evidence for all uses listed, including anorexia, sexual dysfunction, anxiety, cancer, and headache, is insufficient to rate.
How safe is it?
Well-documented data
Rice bran is likely safe in food amounts, but concentrated supplements have limited safety data. When you add bran to your diet, you may experience temporary stomach discomfort, gas, or changes in bowel habits, especially at first.
Rare allergic reactions including severe swelling (anaphylaxis) have been reported. Fenugreek is generally well tolerated but can cause stomach pain, bloating, diarrhea, indigestion, gas, and nausea.
Rare severe allergic reactions are possible. The safety data advises against fenugreek use during pregnancy because it may affect the uterus; however, it is possibly safe while breastfeeding.
Okra has limited human safety data, so the data advises against use during pregnancy and breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Fen-Gre, double-check these medication types with your doctor or pharmacist: antidiabetes drugs (risk of dangerously low blood sugar), anticoagulants and antiplatelet drugs like warfarin and clopidogrel (increased bleeding risk), theophylline, phenytoin, sildenafil, and metoprolol. All of these interactions are moderate severity.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may appeal to you if you're looking for support with cholesterol, sexual function, blood sugar, or menstrual discomfort — but only if none of your current medications interact with it. If you take any diabetes medications, blood thinners, theophylline, phenytoin, sildenafil, or metoprolol, check with your doctor or pharmacist before starting Fen-Gre.
Pregnant or breastfeeding individuals should talk with their healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fen-Gre, straight from the product label.
| Brand | SP Standard Process |
|---|---|
| Barcode (UPC) | 812122010917 |
| Net contents | 150 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 19, 2021 |
| DSLD ID | 256516 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fen-Gre by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Rice Bran | 0 NP | -- |
| Proprietary Blend | 1265 mg | -- |
| Fenugreek | 0 NP | -- |
| Okra | 0 NP | -- |
Other ingredients: Gelatin, Water, Calcium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Three capsules per meal with a full glass of water, or as directed.
Formulation
Gluten free
General Statements
Whole Food Supplements Since 1929
Precautions
Caution: Not to be used during pregnancy and lactation unless otherwise directed by a qualified health care professional.
This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, and shellfish.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fen-Gre by SP Standard Process label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fen-Gre by SP Standard Process
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Gelatin, Water, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.
Fen-Gre by SP Standard Process Drug Interactions
HelloPharmacist Interaction Report
Fen-Gre by SP Standard Process contains fenugreek and okra, both of which interact with medications.
The most serious concern involves fenugreek's moderate interaction with antidiabetes drugs — fenugreek can lower blood sugar (glucose) levels, and when combined with diabetes medications, this may cause dangerously low blood sugar (hypoglycemia).
Read the full breakdown — every affected drug type, severity by severity
Fenugreek also has moderate interactions with blood thinners and antiplatelet drugs (warfarin, clopidogrel, and other anticoagulants/antiplatelets), potentially increasing bleeding risk. Additionally, fenugreek may reduce the effectiveness of theophylline, phenytoin (an anti-seizure medication), and sildenafil, and may lower blood pressure when used with metoprolol.
Okra carries a moderate interaction with antidiabetes drugs for the same reason — it may lower blood sugar when paired with diabetes medications.
Although rice bran has no documented interactions in our data, we could not check several ingredients because they lacked complete interaction data. Altogether, these interactions span 389 individual medications.
Before starting this product, check your exact medications with the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fen-Gre?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fen-Gre interact with 389 drugs. Click any drug to see the details.
2 of the 3 ingredients in Fen-Gre interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Okra
AbciximabReoPro
How Abciximab interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
OkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Acarbose interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
OkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Acetohexamide interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
OkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Albiglutide interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
FenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin interactionOkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
OkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Alogliptin, Metformin interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
FenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin, Pioglitazone interactionOkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Fen-Gre — through 2 ingredients. Tap an ingredient for the detail:
OkraAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Okra + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Fen-Gre — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fen-Gre with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Okra
Antidiabetes Drugs
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that myricetin, a constituent of ambrette, can lower blood glucose levels.
Brand information
Manufacturer and brand details for Fen-Gre, from the product label.
SP Standard Process
See all SP Standard Process products- Name
- Standard Process Inc.
- Street Address
- 1200 West Royal Lee Drive
- City
- Palmyra
- State
- WI
- ZipCode
- 53156
Fen-Gre by SP Standard Process: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fen-Gre is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fen-Gre’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rice Bran
Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most...
Read the full Rice Bran monograph → Herb & supplement monographFenugreek
Interacts with 389 drugsFenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...
Read the full Fenugreek monograph → Herb & supplement monographAmbrette
Interacts with 86 drugsAmbrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breat...
Read the full Ambrette monograph →Sources & How We Checked
Fen-Gre's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 43 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rice Bran 7 references
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
- Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
- Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
- Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
- So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
- Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
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