Glycine 1000 mg Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Glycine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine 1000 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine 1000 mg by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 1000 mg by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine 1000 mg by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: glycine, an amino acid your body makes naturally and uses in protein synthesis and nervous system function. The capsule itself is filled with inactive ingredients — hypromellose, hydroxypropyl cellulose, stearic acid, and silicon dioxide — which are standard tablet and capsule materials.
Does it work?
Not established
Glycine is rated possibly effective for schizophrenia based on available evidence. For other uses listed — 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (BPH), and cystic fibrosis — the evidence we hold is insufficient to rate it either way.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Mild sedation, irritability, insomnia, fatigue, memory problems, headache, and sensory changes have been reported rarely, as have soft stools, nausea, vomiting, upper stomach discomfort, and dry mouth — these resolve quickly if you stop taking it.
The data we have on glycine during pregnancy and breastfeeding is insufficient to know whether it's safe; talk with your doctor or pharmacist for personalized guidance before using it in either situation.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, double-check with your pharmacist before adding this supplement — glycine may reduce its effectiveness. For all other medications, no interactions are documented in our data for glycine.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may help with schizophrenia symptoms, though the evidence is limited. If you take clozapine, check with your pharmacist first — this supplement may reduce how well it works.
Generally well tolerated, but long-term safety hasn't been fully studied.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine 1000 mg, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739001078 |
| Net contents | 100 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 314375 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine 1000 mg by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 3 Gram(s) | -- |
Other ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1-3 capsules daily, preferably on an empty stomach.
Formula
Glycine is the smallest and simplest amino acid, making it versatile for use in a wide range of functions. Glycine is necessary for the production of glutathione, DNA, creatine, bile, hemoglobin, and most proteins. It also helps to promote glycogen storage, thereby making glucose readily available for energy production. Glycine also functions as a calming neurotransmitter in the brain, where it facilitates nerve impulses and is important for the maintenance of healthy sleep patterns.
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Neurotransmitter support Pharmaceutical grade, free-form Promotes restful sleep Nervous system support
Non-GMO
Vegetarian/Vegan
Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.
FDA Statement of Identity
A Dietary Supplement
Seals/Symbols
Triangle K (Kosher)
GMP Quality Assured
General Statements
Amino Acids Family owned since 1968.
Storage
Store in a cool, dry place after opening.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine 1000 mg by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine 1000 mg by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Glycine 1000 mg by NOW Drug Interactions
HelloPharmacist Interaction Report
NOW Glycine 1000 mg has one documented interaction with a medication.
Glycine may theoretically decrease how well clozapine (Clozaril), an antipsychotic used for schizophrenia, works. One small study in patients with schizophrenia found that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared to clozapine alone — the reason isn't entirely clear.
Read the full breakdown — every affected drug type, severity by severity
Altoghether, these interactions span 1 individual medication. If you take clozapine, talk with your pharmacist or doctor before starting this supplement.
You can also use the medication checker on this page to look up your exact drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine 1000 mg, from the product label.
NOW
See all NOW products- Name
- NOW FOODS
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
Glycine 1000 mg by NOW: Common Questions
Does Glycine 1000 mg by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does glycine actually work for schizophrenia?
What side effects might I get from taking this?
Is it safe to take glycine while pregnant or breastfeeding?
Why are there so few interactions with this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC