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Dietary supplement

Gravel Root Ingredients & Drug Interactions

by TerraVita

Gravel Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gravel Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gravel Root is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for kidney stones, urinary tract complaints, fluid retention.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gravel Root Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gravel Root by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Gravel Root by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gravel Root by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

TerraVita Gravel Root contains a single active ingredient: Gravel Root Glycerite Liquid Extract. This is a liquid herbal extract made by soaking gravel root in glycerin, which pulls out the plant's compounds.

The only other ingredient listed is glycerin itself, the liquid medium that carries the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: kidney and urinary tract health.
  • We looked for evidence on: kidney stones, urinary tract infections, bladder irritation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for gravel root. The product facts don't include ratings showing whether it works for any particular condition.

If you're considering this for a specific health goal, it's worth asking your pharmacist what the evidence actually supports.

The evidence, ingredient by ingredient Gravel Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's the frank part: gravel root carries real safety concerns. The plant contains pyrrolizidine alkaloids (PA) — compounds that can cause liver and lung damage.

With long-term or chronic use, especially at higher doses, these alkaloids can trigger veno-occlusive disease, a serious liver condition that causes abdominal pain, vomiting, diarrhea, swelling in the abdomen, and lasting liver enlargement within weeks. Because the safety data is so limited and the liver-toxic risk is genuine, this product should only be used cautiously and for short periods if at all.

For pregnancy and breastfeeding, the safety data isn't there. The product facts rate it as likely unsafe during pregnancy and likely unsafe while nursing.

If you're pregnant, planning pregnancy, or breastfeeding, skip this product and talk with your doctor or pharmacist about what's appropriate for you.

Side effects, ingredient by ingredient Gravel Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gravel Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on lithium for mood disorders, or on any CYP3A4-inducing seizure medications (carbamazepine, phenobarbital, phenytoin), antibiotics (rifampin, rifabutin), or other enzyme-inducing drugs. These are Moderate interactions and may need dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TerraVita Gravel Root is a single-ingredient liquid extract with real liver and lung safety concerns due to its pyrrolizidine alkaloid content. It interacts with lithium and certain seizure and antibiotic medications.

Before you use it, check your exact medications with our tool below, and have a frank conversation with your pharmacist about whether the benefit is worth the documented risks.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gravel Root, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435163990
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280149
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gravel Root by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435163990
IngredientAmount% DV
Gravel Root Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2006 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gravel Root by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gravel Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gravel Root by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Gravel Root Glycerite Liquid Extract

Interacts with
88 drugs
0.13 mL per serving

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scien...

Gravel Root Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gravel Root by TerraVita Drug Interactions

Want to check YOUR meds against Gravel Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
88Drugs
88 Moderate

Ingredients driving the most interactions

Gravel Root Glycerite Liquid Extract 88

Individual Drug Interactions

The ingredients in Gravel Root interact with 88 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gravel Root interact with drugs. Each result below shows which ingredient is responsible. Gravel Root Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gravel Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gravel Root Glycerite Liquid Extract2 drug types · 88 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Lithium

Gravel root is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, gravel root might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Gravel Root Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gravel Root, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Gravel Root by TerraVita: Common Questions

Does Gravel Root by TerraVita interact with any medications?
Yes. Based on its ingredients, Gravel Root has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gravel Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The product facts rate gravel root as likely unsafe during pregnancy and likely unsafe while breastfeeding. The safety data just isn't there to say it's okay. Talk with your doctor or pharmacist about safer options for whatever you're treating.
What are pyrrolizidine alkaloids and why should I care?
They're natural compounds in gravel root that can damage your liver and lungs. With chronic use, they're linked to a serious condition called veno-occlusive disease, which causes abdominal pain, vomiting, diarrhea, and persistent liver swelling. That's why limited and short-term use is the caution here.
I take lithium for bipolar disorder. Is this product safe for me?
Not without talking to your prescriber first. Gravel root's diuretic effect could theoretically reduce how much lithium your kidneys clear, raising lithium levels. Your dose might need adjustment, so this is a conversation for your doctor or pharmacist, not something to start on your own.
What's a glycerite extract?
It's the plant material soaked in glycerin to pull out the active compounds. Glycerin is a sweet liquid that acts as both the extraction medium and the carrier — you're essentially getting the liquid extract of gravel root in a glycerin base.
How long can I safely take this product?
The safety data advises against long-term use. Because of the liver-toxicity risk from pyrrolizidine alkaloids, short-term use with caution is the recommendation. This isn't a supplement to take every day for months. Check with your pharmacist about what 'short-term' means for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gravel Root label
Go deeper

The Full Monographs Behind Gravel Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gravel Root

Interacts with 88 drugs

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scientific evidence to support these uses. Be...

Read the full Gravel Root monograph →
Sources

Sources & How We Checked

Gravel Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gravel Root 5 references
  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

See these in context on the Gravel Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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