GutMD By 1MD Overview & Drug Interactions

L-glutamine is the most abundant free amino acid in the body, produced primarily in skeletal muscle and then released into circulation. It serves vital roles in various tissues, including the immune system, gastrointestinal tract, kidneys, and liver, where it supports essential functions such as maintaining intestinal integrity, immune response, and amino acid balance. Although traditionally classified as a non-essential amino acid, during periods of severe stress, glutamine becomes conditionally essential due to the body's increased demand. It acts as a critical nitrogen and carbon transporter between organs, and while the intestinal mucosa can synthesize glutamine, this production is insufficient during times of significant physiological stress. Dietary supplements generally contain L-glutamine as it is the biologically active form of the amino acid.

Licorice, also known as glycyrrhiza, is a plant native to parts of Europe, Asia, and the Mediterranean region. The root of the plant has been used for centuries in traditional medicine and is often consumed in the form of candy, tea, and supplements. Licorice has a number of purported health benefits, including the ability to soothe sore throats, reduce inflammation, and improve digestive problems. It may also have antiviral and antibacterial properties. Licorice naturally contains glycyrrhizin, or glycyrrhizic acid, which can have toxic effects if consumed in large amounts. However, licorice can be processed to remove glycyrrhizin, resulting in DGL (deglycyrrhizinated licorice). Many dietary supplements that contain deglycyrrhizinated licorice are often simply named 'DGL'.