Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

KrillMD Ingredients & Drug Interactions

by 1MD

KrillMD label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking KrillMD against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

KrillMD is a dietary supplement by 1MD with 6 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, K Real Pure Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against KrillMD by 1MD

Ask about any prescription or over-the-counter medication and we check it for interactions with KrillMD by 1MD — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of KrillMD by 1MD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

KrillMD contains 6 active ingredients: krill oil (a marine source of omega-3 fatty acids), eicosapentaenoic acid and docosahexaenoic acid (two types of omega-3s), phospholipids (fat-based compounds that support cell structure), total omega fatty acids, and astaxanthin (a natural red pigment with antioxidant properties). The softgel capsule also contains gelatin, vegetable glycerin, purified water, and natural lemon oil as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Heart, brain, and eye health support.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Hypertension, Heart failure, Stroke — and 4 related terms.
  • The strongest evidence on file: Krill Oil is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Age-related macular degeneration (AMD), Heart failure, Dry eye, and more.

For krill oil, the evidence shows it's possibly effective for dry eye. The other uses listed — aging skin, Alzheimer disease, cancer, high cholesterol, and cognitive function — lack reliable evidence to rate its effectiveness.

For astaxanthin, the data we hold shows insufficient reliable evidence to rate it for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome.

The evidence, ingredient by ingredient Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both krill oil and astaxanthin are generally well tolerated in studies, though long-term safety data are limited for astaxanthin. Krill oil works best at doses up to 4 grams daily and commonly causes mild gastrointestinal side effects like bloating, diarrhea, fishy burps, heartburn, and nausea — generally milder than with fish oil.

Astaxanthin may cause abdominal pain, diarrhea, or a harmless red color to stool; at higher doses, severe stomach pain has been reported rarely. If you have a shellfish allergy, avoid krill oil; if you have a bleeding disorder, use it with caution.

For pregnancy and breastfeeding, the safety data are insufficient — talk with your doctor before using either ingredient, as the available information doesn't support their use at this time.

Side effects, ingredient by ingredient Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking KrillMD, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate severity — krill oil may increase bleeding risk), diabetes medications (moderate severity — krill oil may lower blood sugar), or medications metabolized by the liver enzymes CYP3A4 or CYP2B6 (moderate severity — astaxanthin may decrease their levels). No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

KrillMD may be worth considering if you have dry eye, since krill oil shows some evidence for that use. However, it's not the right choice if you take blood thinners, antiplatelet drugs, or diabetes medications without checking first with your doctor or pharmacist — the interactions are real and could affect how those drugs work or your bleeding and blood sugar risk.

If you have a shellfish allergy, skip it entirely. Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about KrillMD, straight from the product label.

Brand 1MD
Barcode (UPC) 850008021206
Net contents 60 Lemon-Coated Softgels
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246767
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for KrillMD by 1MD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
850008021206
IngredientAmount% DV
Calories15 Calorie(s)--
Calories from Fat14 Calorie(s)--
Eicosapentaenoic Acid174 mg--
Docosahexaenoic Acid120 mg--
Phospholipids550 mg--
Total Fat1.6 Gram(s)2%
Astaxanthin2 mg--
Total Omega Fatty Acids320 mg--
K Real Pure Krill Oil1600 mg--

Other ingredients: Gelatin, Vegetable Glycerin, purified Water, natural Lemon Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take two (2) softgels daily with an eight ounce glass of water, or as recommended by a healthcare professional.

Precautions

Warning: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking anticoagulants or other medications, have coagulopathy, or any medical condition.

Discontinue use and consult your doctor if ay adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Allergen Warning: Contains shellfish.

Storage

Store in a cool, dry place.

Seals/Symbols

Made in USA GMP Good Manufacturing Practice

Formulation

Clinical-strength omega-3 formula 2x more effective than fish oil

Gluten-free Non-Dairy Non-GMO Soy-free Preservative-free

Formula

Made with highly potent k-real krill oil 1600 mg formula

General Statements

Doctor recommended

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

K-REAL and MSO are registered trademarks of Aker BioMarie.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

KrillMD by 1MD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

KrillMD label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in KrillMD by 1MD

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

174 mg per serving

Docosahexaenoic Acid

120 mg per serving

Phospholipids

550 mg per serving

Astaxanthin

Interacts with
671 drugs
2 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega Fatty Acids

320 mg per serving

K Real Pure Krill Oil

Interacts with
208 drugs
1600 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

K Real Pure Krill Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Glycerin, Purified Water, Natural Lemon Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

KrillMD by 1MD Drug Interactions

Want to check YOUR meds against KrillMD?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
K Real Pure Krill Oil 208

Individual Drug Interactions

The ingredients in KrillMD interact with 838 drugs. Click any drug to see the details.

2 of the 6 ingredients in KrillMD interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin K Real Pure Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in KrillMD with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

K Real Pure Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
K Real Pure Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for KrillMD, from the product label.

1MD

See all 1MD products
Name
1MD
City
Irvine
State
CA
ZipCode
92618
Phone Number
888-393-4030
Web Address
www.1md.org
Pharmacist Counseling Corner

KrillMD by 1MD: Common Questions

Does KrillMD by 1MD interact with any medications?
Yes. Based on its ingredients, KrillMD has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
KrillMD contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take KrillMD if I'm pregnant or breastfeeding?
Not enough safety data exist for either astaxanthin or krill oil during pregnancy or breastfeeding. Talk with your doctor before using this product if you're pregnant or nursing — they can help you weigh the risks and benefits for your situation.
What side effects should I expect?
The most common ones are mild digestive issues: bloating, diarrhea, fishy burps, heartburn, nausea, and stomach discomfort. Astaxanthin may also cause red-colored stool, which is harmless. These effects tend to be milder with krill oil than with regular fish oil. Headache, tiredness, and dizziness have been reported rarely.
Can I take this if I have a shellfish allergy?
No — krill oil comes from shellfish, so avoid this product if you have that allergy.
Will KrillMD help my dry eyes?
Krill oil is possibly effective for dry eye, so it may help — but results vary from person to person. Talk with your eye doctor if dry eye is bothersome; they can discuss whether this product is right for you.
Does this product have fillers or binders?
The softgel capsule contains gelatin, vegetable glycerin, purified water, and natural lemon oil as inactive ingredients. These help form and flavor the capsule but aren't active components.
How much krill oil is in each capsule?
The product facts we have don't specify the amount of krill oil per capsule — check the label on your bottle or the manufacturer's website for that detail.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if KrillMD is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

KrillMD label
Go deeper

The Full Monographs Behind KrillMD’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

KrillMD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team