Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Honeybee Propolis Ingredients & Drug Interactions

by GPI

Honeybee Propolis label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Honeybee Propolis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Honeybee Propolis is a dietary supplement by GPI with 5 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 2,141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Carob, Bee propolis, Honey. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Honeybee Propolis by GPI

Ask about any prescription or over-the-counter medication and we check it for interactions with Honeybee Propolis by GPI — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Honeybee Propolis by GPI

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “A Herbal Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This tablet contains 5 active ingredients: honey, molasses, carob, anise oil, and bee propolis. Each plays a different role in the formulation — honey and propolis are the signature bee-derived components, while carob and anise oil contribute their own traditional uses.

The product also contains several inactive ingredients (dextrose, stearic acid, microcrystalline cellulose, silica, natural and artificial flavor, magnesium stearate, calcium silicate, and riboflavin) that serve as fillers, binders, and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: bioflavonoid-rich natural support for immune and oral health.
  • We looked for evidence on: Herpes labialis (cold sores), Canker sores, Gingivitis, Periodontitis, Denture stomatitis, Oral mucositis — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Honey is rated "Possibly Effective" for Burns, Herpes labialis (cold sores), Cough, Oral mucositis.

Evidence for this product's effectiveness is mixed and limited. Honey is possibly effective for cold sores, cough, burns, dry eye, and oral mucositis (mouth sores from cancer treatment).

Bee propolis is possibly effective for oral mucositis, cold sores, and diabetes. Carob is possibly effective for diarrhea.

Anise oil and molasses lack reliable evidence to establish their effectiveness for the conditions they're traditionally used for — the data we hold shows insufficient evidence for anise in migraines, lice, menopausal symptoms, and PMS, and for carob in athletic performance, diabetes, and familial hypercholesterolemia. Talk with your doctor about whether this supplement fits your specific health goal.

The evidence, ingredient by ingredient Honey Carob Anise Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Honey is generally well tolerated and considered safe as a food for adults and children over 1 year old, though when used medicinally (not just as food) it's worth checking with your doctor first. The most common side effects from honey are nausea, stomach pain, and vomiting when taken by mouth, or burning and stinging when applied to skin.

Carob is safe in normal food amounts, but safety data on concentrated supplement doses is limited — use caution. Anise oil is generally safe as a food or tea, though the concentrated essential oil warrants care; it should be avoided medicinally during pregnancy due to limited safety data.

Bee propolis is generally well tolerated in the short term but can trigger allergic reactions, especially in people sensitive to bee products; headache is reported in around 7% of users. There is not enough reliable safety information for propolis during pregnancy, and it is best avoided; during breastfeeding it is possibly safe but again warrants discussion with your provider.

We hold no pregnancy and lactation data for molasses.

Side effects, ingredient by ingredient Honey Carob Anise Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Carob, Propolis, Anise, Honey.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 2,142 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check the following medication types with your doctor or pharmacist. Moderate-severity concerns: blood thinners and antiplatelet drugs (honey and propolis may increase bleeding risk); seizure medications like phenytoin (honey may raise levels); diabetes medications (anise oil may lower blood sugar); birth control pills and estrogen therapy (anise oil may interfere); antidepressants including fluoxetine and imipramine (anise oil may reduce effectiveness); diazepam (Valium), codeine, and caffeine (anise oil may alter effects); drugs metabolized by your liver's CYP enzymes — including many common medications — (propolis may raise levels); and warfarin (Coumadin), where animal data suggests propolis may decrease its effectiveness.

Minor concerns: some drugs metabolized by CYP3A4 (honey's effect on these is conflicting), and oral medications in general (carob may reduce absorption). No interactions are documented for the ingredients we could check, but that does not guarantee none exist — run your full medication list through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for traditional bee-based wellness support, particularly for cough, cold sores, or mouth sores from cancer treatment, though the evidence is modest. If you take any prescription or over-the-counter medications — especially blood thinners, seizure medications, diabetes drugs, antidepressants, or birth control — you need to check this product against your specific medications first.

Pregnant or breastfeeding? Talk with your doctor or pharmacist; propolis especially needs clearance.

Before you start, search your medications on this page and discuss any concerns with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Honeybee Propolis, straight from the product label.

Brand GPI
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28680
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Honeybee Propolis by GPI, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
180
IngredientAmount% DV
Honey0 NP--
Molasses0 NP--
Carob0 NP--
Anise Oil0 NP--
Bee propolis0 NP--
A Herbal Blend500 mg--

Other ingredients: Dextrose, Stearic Acid, Microcrystalline Cellulose, Silica, Natural & Artificial Flavor, Magnesium Stearate, Calcium Silicate, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Note: The color, taste, and texture of this product may vary due to its natural ingredients and/or seasonal changes.

While its usage has been recorded in ancient Egyptian writings, propolis continues to be the choice for people looking for a rich, natural concentration of bioflavonoids. These bioflavonoids enhance the effectiveness of vitamin C and help fortify the body's defense system. Honeybee Propolis is a protective substance metabolized be bees. Records of its dietary and topical uses date back to the ancient Greek physician, Hippocrates (460-377 B.C.)

Nature's Immunity Defender

Precautions

Keep out of reach of children

Do not purchase if seal is broken

Warning: Consult your physician prior to using this product if you are pregnant, nursing or have any pre-existing medical conditions.

Made in the USA

Storage

Protect from heat, light, and moisture Store at 59-86(0)F (15-30(0)C)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: One tablet may be chewed or swallowed twice daily. More may be taken to achieve desired results.

Seals/Symbols

GPi

FDA Statement of Identity

Dietary Supplement

General

Item #100851

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Honeybee Propolis by GPI label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Honeybee Propolis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Honeybee Propolis by GPI

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A Herbal Blend

500 mg per serving

Other (inactive) ingredients: Dextrose, Stearic Acid, Microcrystalline Cellulose, Silica, Natural & Artificial Flavor, Magnesium Stearate, Calcium Silicate, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Honeybee Propolis by GPI Drug Interactions

Want to check YOUR meds against Honeybee Propolis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,141Drugs
996 Moderate 1,145 Minor

Ingredients driving the most interactions

Carob 2,022
Bee propolis 921
Honey 736
Anise Oil 245

Individual Drug Interactions

The ingredients in Honeybee Propolis interact with 2,141 drugs. Click any drug to see the details.

4 of the 5 ingredients in Honeybee Propolis interact with drugs. Each result below shows which ingredient is responsible. Carob Bee propolis Honey Anise Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Honeybee Propolis with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Carob1 drug type · 2,022 drugs

Oral Drugs

Theoretically, carob might also impair the absorption of oral drugs.
Laboratory research shows that carob, when consumed as part of the diet or used as a thickening agent in infant formula, reduces the absorption of certain minerals. Take carob 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Carob full monograph & interactions

Bee propolis8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
Bee propolis full monograph & interactions

Honey3 drug types · 736 drugs

Phenytoin (Dilantin)

Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.

Likelihood Possible Evidence B
Honey full monograph & interactions

Anise Oil11 drug types · 245 drugs

Antidiabetes Drugs

Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A small clinical study shows that anise seed powder decreases fasting blood glucose levels by 36% when compared to baseline.

Likelihood Possible Evidence B
Caffeine

Theoretically, anise oil might decrease the efficacy of caffeine.
Animal research shows that taking anise oil with caffeine decreases the bioavailability of caffeine. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Codeine

Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, anise might interfere with contraceptive drug therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Diazepam (Valium)

Theoretically, anise oil might increase the effects and adverse effects of diazepam.
Animal research shows that taking anise oil with diazepam increases the motor impairment associated with diazepam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Estrogens

Theoretically, anise might interfere with estrogen-based hormone replacement therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Fluoxetine (Prozac)

Theoretically, anise oil might decrease the efficacy of fluoxetine.
Animal research shows that taking anise oil with fluoxetine reduces the antidepressant effects of fluoxetine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Imipramine (Tofranil)

Theoretically, anise oil might decrease the efficacy of imipramine.
Animal research shows that taking anise oil with imipramine reduces the antidepressant effects of imipramine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, anise oil might increase the effects and adverse effects of midazolam.
Animal research shows that taking anise oil with midazolam increases the motor impairment associated with midazolam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, anise might interfere with tamoxifen therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Animal research shows that taking anise oil with acetaminophen decreases peak plasma levels of acetaminophen but does not reduce overall bioavailability. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Anise Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Honeybee Propolis, from the product label.

GPI

See all GPI products
Name
Golden Pride International
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
800-575-1634
Web Address
www.goldenprideonline.com
Pharmacist Counseling Corner

Honeybee Propolis by GPI: Common Questions

Does Honeybee Propolis by GPI interact with any medications?
Yes. Based on its ingredients, Honeybee Propolis has a known interaction with 2,141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Honeybee Propolis contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Honeybee Propolis safe during pregnancy or breastfeeding?
Honey and anise oil are likely safe in pregnancy, but bee propolis — a key ingredient here — doesn't have enough reliable safety data, so it's best avoided during pregnancy. During breastfeeding, propolis is possibly safe, though there isn't much data. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing, so they can weigh the benefits against what we know (and don't know) about safety.
What are the most common side effects?
From honey, you might experience nausea, stomach pain, or vomiting if taken by mouth. Bee propolis can cause mild headache — about 7% of people in a trial reported this. Both honey and propolis may trigger allergic reactions, especially if you're sensitive to bee products. Anise oil can occasionally cause contact dermatitis on the skin.
Does this product actually work for colds or cough?
Honey in this product is possibly effective for cough and cold sores based on the evidence we hold. Bee propolis is also possibly effective for cold sores. That said, 'possibly effective' means the evidence is modest, not that it's proven — talk with your doctor if you're counting on it to treat or prevent a serious illness.
Can I take this with blood thinners like warfarin?
Both honey and bee propolis in this product may increase bleeding risk or interfere with blood thinners. Propolis animal data also suggests it might reduce warfarin's effectiveness. This is not something to do on your own — check with your doctor or pharmacist first, especially if you take warfarin or any other anticoagulant or antiplatelet drug.
What's in this product besides the active ingredients?
Besides honey, molasses, carob, anise oil, and bee propolis, the product contains inactive ingredients: dextrose, stearic acid, microcrystalline cellulose, silica, natural and artificial flavor, magnesium stearate, calcium silicate, and riboflavin. These are fillers, binders, and capsule materials.
Is bee propolis safe if I'm allergic to bee products?
No. Bee propolis can trigger allergic reactions, including severe ones, especially in people sensitive to bees or bee products. If you have a bee allergy, avoid this product and talk with your doctor or pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Honeybee Propolis is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Honeybee Propolis label
Go deeper

The Full Monographs Behind Honeybee Propolis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Honey

Interacts with 736 drugs

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for...

Read the full Honey monograph → Herb & supplement monograph

Carob

Interacts with 2,022 drugs

Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum). It is mostly eaten as a food and is generally w...

Read the full Carob monograph → Herb & supplement monograph

Anise

Interacts with 245 drugs

Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition and small or laboratory studies rather th...

Read the full Anise monograph → Herb & supplement monograph

Propolis

Interacts with 921 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph →
Sources

Sources & How We Checked

Honeybee Propolis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Honey 40 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
  4. Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
  5. Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
  6. Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
  7. Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
  8. Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
  9. Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
  10. Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
  11. Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
  12. Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
  13. van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
  14. Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
  15. Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., and Haftbaradaran, E. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med 2007;7:13. PubMed
  16. Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed
  17. Akinci, S., Arslan, U., Karakurt, K., and Cengel, A. An unusual presentation of mad honey poisoning: acute myocardial infarction. Int J Cardiol 2008;129(2):e56-e58. PubMed
  18. Yildirim, N., Aydin, M., Cam, F., and Celik, O. Clinical presentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26(1):108.e-2. PubMed
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Carob 9 references
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Anise 12 references
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Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
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See these in context on the Propolis monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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