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Dietary supplement

Kyo-Chlorella Ingredients & Drug Interactions

by Kyo-Chlorella

Kyo-Chlorella label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kyo-Chlorella against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kyo-Chlorella is a dietary supplement by Kyo-Chlorella with 1 active ingredient. Its ingredients are commonly taken for general nutrition and 'detox' support, immune support, liver and kidney support.Based on those ingredients, 337 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 100% pure broken cell wall Chlorella powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kyo-Chlorella by Kyo-Chlorella

Ask about any prescription or over-the-counter medication and we check it for interactions with Kyo-Chlorella by Kyo-Chlorella — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kyo-Chlorella by Kyo-Chlorella

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Kyo-Chlorella is one active ingredient: 100% pure broken cell wall chlorella powder. Chlorella is a freshwater algae that's been studied for several health uses.

The product also contains tricalcium phosphate as an inactive ingredient (a binder).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Chlorella's overall clinical evidence instead.

Moderate

Some clinical evidence supports Chlorella for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Pregnancy-related iron deficiency — rated "Possibly Effective" (Natural Medicines).

The evidence we hold rates chlorella possibly effective for pregnancy-related iron deficiency. For brain tumor, nonalcoholic fatty liver disease, depression, and fatigue, the evidence is insufficient—meaning the data isn't strong enough to say whether it works.

If you're considering chlorella for one of those other uses, talk with your doctor about whether the current evidence supports it.

The evidence, ingredient by ingredient Chlorella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorella is generally well tolerated over the short term, though product quality and purity vary widely from brand to brand. The most common side effects are allergic reactions, abdominal cramping, constipation, diarrhea, fatigue, gas, nausea, photosensitivity (rash on sun-exposed skin), and green discoloration of stool—especially during the first two weeks.

Rare but serious adverse effects include anaphylaxis (a severe allergic reaction). Because long-term safety data is limited, the facts advise against taking this unless your doctor approves.

Side effects, ingredient by ingredient Chlorella

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chlorella.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 337 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Kyo-Chlorella, check with your doctor or pharmacist if you take warfarin (Coumadin) or any photosensitizing drugs. Chlorella's vitamin K may reduce warfarin's effectiveness, and the supplement itself can cause photosensitivity reactions that might worsen with photosensitizing medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Kyo-Chlorella may help with pregnancy-related iron deficiency, but it interacts significantly with warfarin and photosensitizing drugs, and long-term safety isn't well established. If you take warfarin or any photosensitizing medication, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting it.

Even if you don't take those drugs, run your exact medications through the checker on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kyo-Chlorella, straight from the product label.

Brand Kyo-Chlorella
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42451
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kyo-Chlorella by Kyo-Chlorella, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Tablet(s)
Maximum serving Sizes:
6 Tablet(s)
IngredientAmount% DV
100% pure broken cell wall Chlorella powder3 Gram(s)--

Other ingredients: Tricalcium Phosphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Chlorella Supplement

General Statements

NATURAL PHYTONUTRIENT SOURCE ANTIOXIDANT

The superior digestibility provides a pure, potent source of protein. Kyo-Chlorella provides antioxidant protection and healthy immune function.* Enjoy Kyo-Chlorella for a daily burst of organic energy!

Formula

100% Pure Broken Cell Wall Nutritious Green Chlorella

This power-packed whole food source provides over 19 amino acids including all 8 essential amino acids, plus beta-carotene, potassium and other valuable vitamins and minerals.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 6 tablets daily.

Formulation

FREE OF: excipients, wheat, corn, soy, sugar, dairy, sodium, preservatives, artificial colors and flavors.

Storage

Sore in a cool, dry place with cap tight. Keep away from direct light.

Precautions

Keep out of reach of children.

California Proposition 65 Statement WARNING: This product contains lead, a chemical known to the State of California to cause cancer, birth defects or other reproductive harm.

SAFETY SEALED: Do not use if inner seal is broken or missing.

General

L710A31G

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Kyo-Chlorella(R) is a specifically cultivated green algae known as one of the best sources of natural chlorophyll and edible fiber made with a unique broken cell wall process to enhance bio-availability for better assimilation of nutrients.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kyo-Chlorella by Kyo-Chlorella label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kyo-Chlorella label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kyo-Chlorella by Kyo-Chlorella

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size6 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

100% pure broken cell wall Chlorella powder

Interacts with
337 drugs
3 Gram(s) per serving

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies sugges...

100% pure broken cell wall Chlorella powder monograph & interactions

Other (inactive) ingredients: Tricalcium Phosphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kyo-Chlorella by Kyo-Chlorella Drug Interactions

Want to check YOUR meds against Kyo-Chlorella?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
337Drugs
337 Moderate

Ingredients driving the most interactions

100% pure broken cell wall Chlorella powder 337

Individual Drug Interactions

The ingredients in Kyo-Chlorella interact with 337 drugs. Click any drug to see the details.

1 of the 1 ingredient in Kyo-Chlorella interact with drugs. Each result below shows which ingredient is responsible. 100% pure broken cell wall Chlorella powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Kyo-Chlorella with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

100% pure broken cell wall Chlorella powder2 drug types · 337 drugs

Photosensitizing Drugs

Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.

Likelihood Possible Evidence D
100% pure broken cell wall Chlorella powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kyo-Chlorella, from the product label.

Kyo-Chlorella

See all Kyo-Chlorella products
Name
WAKUNAGA of AMERICA CO., LTD.
Street Address
23501 Madero
City
MISSION VIEJO
State
CA
ZipCode
92691
Web Address
www.kyo-green.com www.kyolic.com
Pharmacist Counseling Corner

Kyo-Chlorella by Kyo-Chlorella: Common Questions

Does Kyo-Chlorella by Kyo-Chlorella interact with any medications?
Yes. Based on its ingredients, Kyo-Chlorella has a known interaction with 337 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kyo-Chlorella contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will chlorella interfere with warfarin (Coumadin)?
Yes—possibly. Chlorella contains significant amounts of vitamin K, which can reduce warfarin's blood-thinning effects. There's at least one case report of warfarin becoming less effective after someone started chlorella. If you take warfarin, you need to talk with your doctor or pharmacist before starting this product.
Can I take chlorella if I'm sensitive to sun exposure?
Chlorella can cause photosensitivity reactions (rash and swelling on sun-exposed skin) in some people. If you take a medication that makes you photosensitive, or if you've had photosensitivity before, talk with your doctor or pharmacist first—the risk could be higher for you.
What are the most common side effects?
The most common are allergic reactions, stomach cramping, constipation, diarrhea, fatigue, gas, nausea, and stool discoloration. These tend to happen especially in the first two weeks. Serious allergic reactions like anaphylaxis are rare but possible.
Is chlorella safe during pregnancy?
Chlorella is rated possibly safe in pregnancy, but we don't have complete long-term safety data. Talk with your doctor or pharmacist about whether it's appropriate for you and your pregnancy.
What does chlorella actually do?
The evidence we hold is strongest for pregnancy-related iron deficiency, where it's rated possibly effective. For brain tumor, fatty liver disease, depression, and fatigue, the evidence isn't strong enough to say it works. Ask your doctor whether there's a good reason to use it for your situation.
Does product quality matter with chlorella?
Yes—quality and purity vary widely from brand to brand. That's why it's important to choose a reputable supplier and to talk with your doctor or pharmacist about which product they'd recommend.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kyo-Chlorella label
Go deeper

The Full Monographs Behind Kyo-Chlorella’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorella

Interacts with 337 drugs

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...

Read the full Chlorella monograph →
Sources

Sources & How We Checked

Kyo-Chlorella's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorella 13 references
  1. Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
  2. Ng TP, Tan WC, Lee YK. Occupational asthma in a pharmacist induced by chlorella, a unicellular algae preparation. Resp Med 1994;88:555-7. PubMed
  3. Jitsukawa K, Suizu R, Hidano A. Chlorella photosensitization. New phytophotodermatosis. Int J Dermatol 1984;23:263-8. PubMed
  4. Merchant RE, Carmack CA, Wise CM. Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 2000;14:167-73.
  5. Merchant RE, Rice CD, Young HF. Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival. Phytother Res 1990;4:220-31.
  6. Halperin SA, Smith B, Nolan C, et al. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ 2003;169:111-7..
  7. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., and Kobayashi, S. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Am J Kidney Dis 2005;46(4):749-753. PubMed
  8. Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. Respir.Med. 1994;88(7):555-557. PubMed
  9. Ohkawa, S., Yoneda, Y., Ohsumi, Y., and Tabuchi, M. [Warfarin therapy and chlorella]. Rinsho Shinkeigaku 1995;35(7):806-807.
  10. Azocar J, Diaz A. Efficacy and safety of chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol 2013;19(7):1085-90. PubMed
  11. Panahi Y, Badeli R, Karami GR, Badeli Z, Sahebkar A. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. Complement Ther Med 2015;23(4):598-602. PubMed
  12. Nakano S, Takekoshi H, Nakano M. Chlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant women. Plant Foods Hum Nutr 2010;65(1):25-30. PubMed
  13. Yavasoglu I, Turgutkaya A, Bolaman Z. Chlorella-induced thrombocytopenia. Sao Paulo Med J 2018;136(6):602-3. PubMed

See these in context on the Chlorella monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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