Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Lemon Balm Force Ingredients & Drug Interactions

by New Chapter

Lemon Balm Force label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon Balm Force against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lemon Balm Force is a dietary supplement by New Chapter with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon Balm Force by New Chapter

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HelloPharmacist Scorecard of Lemon Balm Force by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Lemon Balm Force contains 2 active ingredients, both forms of lemon balm (Melissa officinalis): a hydroethanolic extract made from leaf and stem, and a supercritical extract. The product also includes inactive ingredients — extra virgin olive oil, hypromellose, yellow beeswax, and candelilla wax — which are excipients that help form and deliver the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lemon Balm's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lemon Balm for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Herpes labialis (cold sores) — rated "Possibly Effective" (Natural Medicines).
  • On file: Depression — rated "Possibly Effective" (Natural Medicines).
  • On file: Stress — rated "Possibly Effective" (Natural Medicines).

Lemon balm is listed as possibly effective for cold sores (herpes labialis), stress, and depression based on the evidence we have on file. That means some clinical trials show a benefit, but the research isn't airtight yet.

If you're thinking about this product for one of those reasons, it may be worth a try, but it's not a substitute for medical care if you have depression or a diagnosed cold sore infection.

The evidence, ingredient by ingredient Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in healthy adults, but high doses and long-term safety haven't been studied much. In trials, dizziness and sedation were reported, but they didn't happen more often than placebo.

One rare case of heart rhythm changes was reported in someone taking a multi-ingredient product containing lemon balm, though it's unclear whether lemon balm was the cause. The safety data advises against use during pregnancy unless your doctor says otherwise.

If you're breastfeeding, there isn't enough information to know either way — talk to your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use CNS depressants (sedatives, sleep aids, anti-anxiety medications) or thyroid hormone replacement therapy. Lemon balm may intensify drowsiness from the first group and may interfere with how well the second group works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Lemon Balm Force may help with cold sores, stress, or low mood if you're looking for a herbal option. If you take sedatives, sleep aids, anxiety medications, or thyroid replacement therapy, check with your own doctor or pharmacist before starting this product, since it can interact with those drug types.

For any questions about how it fits into your personal health routine, talk it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon Balm Force, straight from the product label.

Brand New Chapter
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 288205
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon Balm Force by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract200 mg--
Lemon Balm supercritical extract100 mg--

Other ingredients: Extra Virgin Olive Oil, Hypromellose, Yellow Beeswax, Candelilla Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One capsule daily with food.

Precautions

Not recommended for use in children.

Caution: As with any dietary supplement, you should advise your healthcare professional of the use of this product.

If you are nursing, pregnant, or considering pregnancy, you should consult your healthcare professional prior to using this product.

Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction.

Do not exceed suggested use.

Keep out of reach of children.

Formulation

Certified Gluten-Free by NSF; 100% Vegetarian; no artificial flavors or colors.

Certified Gluten-Free by NSF; 100% Vegetarian; no artificial flavors or colors.

Calm, balanced mood & relaxation

Non GMO Project Verified nongmoproject.org NSF Certified Gluten-Free

General Statements

Please refer to newchapter.com for more information about this product and its benefits.

Please recycle this bottle after use.

For questions or comments call 888-874-4461

Brand IP Statement(s)

Copyright 2020 New Chapter, Inc Est. 1982

Formula

Pure & potent extracts

Seals/Symbols

Non GMO Project Verified nongmoproject.org NSF Certified Gluten-Free Certified B Corporation

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon Balm Force by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon Balm Force label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon Balm Force by New Chapter

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract

Interacts with
264 drugs
200 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract monograph & interactions

Lemon Balm supercritical extract

Interacts with
264 drugs
100 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm supercritical extract monograph & interactions

Other (inactive) ingredients: Extra Virgin Olive Oil, Hypromellose, Yellow Beeswax, Candelilla Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon Balm Force by New Chapter Drug Interactions

Want to check YOUR meds against Lemon Balm Force?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract 264

Individual Drug Interactions

The ingredients in Lemon Balm Force interact with 264 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lemon Balm Force interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon Balm Force with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm (Melissa officinalis) (leaf and stem) hydroethanolic extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon Balm Force, from the product label.

New Chapter

See all New Chapter products
Name
New Chapter, Inc.
Street Address
90 Technology Drive
City
Brattleboro
State
VT
ZipCode
05301
Phone Number
888-874-4461
Web Address
www.newchapter.com/guarantee
Pharmacist Counseling Corner

Lemon Balm Force by New Chapter: Common Questions

Does Lemon Balm Force by New Chapter interact with any medications?
Yes. Based on its ingredients, Lemon Balm Force has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon Balm Force contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Lemon Balm Force if I'm pregnant?
The safety data advises against it during pregnancy unless your doctor says it's okay. If you're pregnant or planning to be, talk to your doctor before using this product.
Will this help my cold sores?
Lemon balm is possibly effective for cold sores based on the evidence we have. That means some studies show it helps, but the research isn't completely solid yet — it may be worth trying, but it's not a guaranteed cure.
Can I use this long-term?
Lemon balm is generally well tolerated for short-term use, but long-term safety at high doses hasn't been well studied. If you want to use it regularly for weeks or months, check with your doctor or pharmacist first.
What does lemon balm do?
Lemon balm is an herb that may help reduce stress, support mood, and help heal cold sores. It seems to have a calming effect on the nervous system based on how it works in animals and humans.
Will it make me drowsy?
Dizziness and sedation have been reported with lemon balm, but studies show these don't happen more often than with placebo. If you do feel drowsy, don't drive or operate machinery until you see how it affects you.
Is it safe to use while breastfeeding?
There isn't enough safety information to know either way. Talk to your doctor or pharmacist before using this product if you're breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon Balm Force is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon Balm Force label
Go deeper

The Full Monographs Behind Lemon Balm Force’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Lemon Balm Force's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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