Meta I 3 C Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking Meta I 3 C against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Meta I 3 C is a dietary supplement by Metagenics with 2 active ingredients. Its ingredients are commonly taken for estrogen and hormone balance support, breast and cervical health, prostate health.Based on those ingredients, 384 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary Leaf Extract, Indole-3-Carbinol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Meta I 3 C by Metagenics
Ask about any prescription or over-the-counter medication and we check it for interactions with Meta I 3 C by Metagenics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Meta I 3 C by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Meta I 3 C contains 2 active ingredients. Indole-3-carbinol is a compound derived from cruciferous vegetables like broccoli and cabbage.
Rosemary leaf extract is a concentrated form of the culinary herb rosemary. The product also includes inactive ingredients — hydroxypropyl methylcellulose, maltodextrin, magnesium stearate, and silica — which serve as capsule material, binder, and flow agents.
Does it work?
Not established
The evidence for indole-3-carbinol is limited. Our data shows insufficient reliable evidence to rate it for breast cancer, colorectal cancer, cervical dysplasia, liver disease, and fibromyalgia.
Rosemary leaf extract is possibly effective for memory, but evidence is insufficient for age-related cognitive decline, alopecia areata, and fatty liver disease. For other uses, the data we hold does not establish effectiveness.
How safe is it?
Well-documented data
Indole-3-carbinol is generally well tolerated orally, though diarrhea, nausea, rash, tremor, and unsteadiness have been reported. Higher doses or longer use may increase the risk of imbalance and tremor — one case showed these effects at 800 mg daily, which resolved when the dose was cut in half.
During pregnancy, there isn't enough safety data to know either way; talk with your doctor or pharmacist for personalized advice. The safety data advises against concentrated supplements while breastfeeding.
Rosemary leaf extract in normal food amounts is safe, but concentrated extracts and undiluted oils require caution. Topically, allergic reactions including dermatitis and lip or gum swelling have occurred.
Oral use of undiluted oil may cause seizures.
Meds to double-check
Moderate interaction found
Before taking Meta I 3 C, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (moderate risk of bleeding), estrogen therapy (may reduce effectiveness), diabetes medications (may lower blood sugar too far), aspirin or other salicylate-based pain relievers, or drugs metabolized by the enzyme CYP1A2. The search tool on this page can help you look up your exact medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Meta I 3 C is mainly a concern if you take blood thinners, diabetes medications, estrogen therapy, or aspirin. The product itself is generally well tolerated in most people, but imbalance and tremor can happen at higher doses.
If you're pregnant, breastfeeding, or on any regular medications, talk with your doctor or pharmacist before starting — the interaction profile is broad enough to warrant a quick check of your specific situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Meta I 3 C, straight from the product label.
| Brand | Metagenics |
|---|---|
| Barcode (UPC) | 755571019523 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2023 |
| DSLD ID | 295761 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Meta I 3 C by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Indole-3-Carbinol | 150 mg | -- |
| Rosemary Leaf Extract | 50 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Maltodextrin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Meta I 3 C is designed to promote healthy estrogen metabolism and balance by featuring indole-3-carbinol (I3C), a nature-identical version of the compound found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Through its ability to promote the breakdown of estrogen to its beneficial, protective metabolite-2-hydroxyestrone-indole-3-carbinol may be a safe and effective way to help achieve beneficial balance in estrogen metabolism.
Stabilized indole-3-carbinol
Suggested/Recommended/Usage/Directions
Directions: Take one capsule twice daily with food or as directed by your healthcare practitioner.
Formulation
This product is gluten-free and vegetarian.
This product is gluten-free and vegetarian.
Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)
Precautions
Caution: Not recommended for pregnant or nursing women. If taking medication, consult your healthcare practitioner before use.
Keep out of the reach of children.
Practitioner Exclusive
Seals/Symbols
Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Meta I 3 C by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Meta I 3 C by Metagenics
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Indole-3-Carbinol
Interacts with294 drugs
Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...
Indole-3-Carbinol monograph & interactionsRosemary Leaf Extract
Interacts with372 drugs
Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...
Rosemary Leaf Extract monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Maltodextrin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Meta I 3 C by Metagenics Drug Interactions
HelloPharmacist Interaction Report
Meta I 3 C by Metagenics interacts with medications through its indole-3-carbinol and rosemary leaf extract.
The most serious finding is a moderate-severity risk of increased bleeding with blood thinners (anticoagulants) and antiplatelet drugs — both ingredients may slow clotting. Indole-3-carbinol also carries moderate concern for hormone-related interactions with estrogen therapy, potentially reducing its effectiveness, and may speed up how your liver breaks down certain drugs (CYP1A2 substrates), which could lower their levels in your blood.
Read the full breakdown — every affected drug type, severity by severity
Rosemary leaf extract adds moderate concerns with diabetes medications — it may lower blood sugar further and raise the risk of low blood sugar (hypoglycemia) — and with aspirin and other salicylate-containing pain relievers, where effects might add up. It also has a minor interaction with CYP1A2 substrates, similar to indole-3-carbinol.
Altogether, these interactions span 384 individual medications. Use the search tool below to check your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Meta I 3 C?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Meta I 3 C interact with 384 drugs. Click any drug to see the details.
2 of the 2 ingredients in Meta I 3 C interact with drugs. Each result below shows which ingredient is responsible. Rosemary Leaf Extract Indole-3-Carbinol
AbciximabReoPro
How Abciximab interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Abciximab interactionRosemary Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary Leaf Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Rosemary Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary Leaf Extract + Abrocitinib interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Meta I 3 C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary Leaf Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Rosemary Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary Leaf Extract + Acenocoumarol interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Rosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Aspirin interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Aspirin, Caffeine interactionRosemary Leaf ExtractAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Rosemary Leaf Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Caffeine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Caffeine, Codeine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Codeine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Codeine Phosphate interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Codeine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Dihydrocodeine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Isometheptene interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Pyrilamine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Phenylephrine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Meta I 3 C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionRosemary Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary Leaf Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Meta I 3 C with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rosemary Leaf Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.
Aspirin
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.
Salsalate (Disalcid)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.
Indole-3-Carbinol
Anticoagulant/Antiplatelet Drugs
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.
Estrogens
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.
Brand information
Manufacturer and brand details for Meta I 3 C, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Gig Harbor
- State
- WA
- ZipCode
- 98332
- Phone Number
- 800 692 9400
- Web Address
- metagenics.com
Meta I 3 C by Metagenics: Common Questions
Does Meta I 3 C by Metagenics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does indole-3-carbinol actually work for cancer or other diseases?
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Can I breastfeed while taking this?
Is rosemary safe to use in this supplement form?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Meta I 3 C is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Meta I 3 C’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Indole-3-carbinol
Interacts with 294 drugsIndole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...
Read the full Indole-3-carbinol monograph → Herb & supplement monographRosemary
Interacts with 372 drugsRosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...
Read the full Rosemary monograph →Sources & How We Checked
Meta I 3 C's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Indole-3-carbinol 9 references
- Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
- Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
- He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
- Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
- Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
- McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
- Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
- Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
- Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed
Rosemary 20 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
- Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
- Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
- Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
- Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
- Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
- Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
- Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
- Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
- Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
- Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC