Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Munogen Ingredients & Drug Interactions

by FitLine

Munogen label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Munogen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Munogen is a dietary supplement by FitLine with 6 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 452 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine, Vitamin B6, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Munogen by FitLine

Ask about any prescription or over-the-counter medication and we check it for interactions with Munogen by FitLine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Munogen by FitLine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (105 mcg DFE) without saying how much of each component you get.

Munogen contains five active ingredients. Folic acid supports cell division and is used to prevent birth defects and treat folate deficiency.

Vitamin B6 helps your body use amino acids and is needed for nerve and brain development. Vitamin B12 is essential for red blood cells and nerve function.

L-arginine is an amino acid that your body uses to make nitric oxide, which relaxes blood vessels. L-citrulline is another amino acid your body converts to L-arginine.

The product also contains several inactive ingredients—grape extract, apple extract, capsule shell, inca wheat extract, anti-caking agent, glucose syrup, and flavor—that serve as excipients and taste.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Amino acids and vitamins dietary supplement.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Fatigue, Folate deficiency, Anemia, Blood flow — and 2 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Effective" for Sideroblastic anemia (Natural Medicines).
  • Also on file: Folic Acid is rated "Effective" for Folate deficiency.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Folic acid in this product is effective for treating folate deficiency and likely effective for preventing neural tube birth defects and reducing methotrexate toxicity; it's possibly effective for depression and cognitive impairment. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and likely effective for high homocysteine levels.

Vitamin B12 is effective for B12 deficiency. For L-arginine and L-citrulline, we hold no effectiveness ratings in our data.

The evidence supporting L-citrulline for athletic performance is only possibly effective, and its use for diabetes, heart failure, and cardiovascular disease is rated insufficient to establish benefit.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 L-arginine L-citrulline Folic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid is generally well tolerated at recommended doses in most adults and is recommended during pregnancy to prevent birth defects. It's considered safe while breastfeeding at normal amounts.

At higher doses (5–15 mg daily), some people report abdominal cramps, diarrhea, rash, bitter taste, nausea, and sleep disturbances. Folic acid use late in pregnancy has been linked to increased childhood asthma risk in population studies, though early pregnancy or pre-pregnancy use showed no such association.

Vitamin B6 is safe at normal food amounts and standard supplements, but high doses over time can cause sensory nerve damage (neuropathy). Vitamin B12 is generally very safe with no established upper limit.

L-arginine and L-citrulline have incomplete pregnancy and breastfeeding data; the facts advise avoiding L-citrulline in pregnancy and breastfeeding due to insufficient safety data. L-arginine's safety during these periods is not on file.

Both amino acids are generally well tolerated orally, though they can cause gastrointestinal discomfort, nausea, headache, and (for L-arginine) flushing or insomnia.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 L-arginine L-citrulline Folic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — L-arginine, Vitamin B12, Vitamin B6, Folic Acid, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 452 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take seizure drugs (phenobarbital, phenytoin, primidone), cancer treatments (methotrexate, capecitabine, 5-fluorouracil), blood pressure medications (ACE inhibitors, ARBs, or other antihypertensives), blood thinners or antiplatelet drugs, diabetes medications, potassium-sparing diuretics, or erectile dysfunction drugs like sildenafil. These are the Moderate severity concerns.

Vitamin B12 also has a Minor interaction with metformin. Ask your pharmacist if any of your prescriptions overlap.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Munogen is a multivitamin supplement aimed at general B vitamin and amino acid support. If you take medications for seizures, cancer, blood pressure, blood clotting, diabetes, or erectile dysfunction, check your exact drugs with the interaction tool on this page before starting.

Pregnant or breastfeeding people should talk with their doctor or pharmacist before use, especially regarding L-citrulline. Run this by your pharmacist—the interaction load is real and worth a quick cross-check.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Munogen, straight from the product label.

Brand FitLine
Net contents 60 Capsule(s); 42.9 Gram(s); 1.51 oz.
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 181763
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Munogen by FitLine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Calories4 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Folic Acid63 mcg--
Vitamin B60.44 mg26%
Vitamin B120.788 mcg33%
L-Arginine396 mg--
L-Citrulline58.5 mg--
Protein0.6 Gram(s)1%
Folate105 mcg DFE26%
Total Fat0 Gram(s)--

Other ingredients: Grape extract, Apple extract, Capsule Shell, Inca Wheat-extract, Anti-Caking Agent, Glucose Syrup, Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Not a significant source of cholesterol, added sugar or sodium.

Formula

This product contains sulfiting agents.

Precautions

This product contains sulfiting agents.

Caution: Do not exceed the recommended servings per day. Dietary supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Keep out of reach of young children.

General Statements

New

Made in Germany

Dietary supplement with amino acids and vitamins.

60 capsules 0.715 g/0.025 oz.

Excellent product quality in conformance with international GMP standard.

German quality. Manufactured and packaged exclusively for the PM-International Group.

Seals/Symbols

NTC Nutrient Transport Concept Made in Germany

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

US Daily Recommendation: Take 2 capsules a day along with plenty of liquid.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Munogen by FitLine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Munogen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Munogen by FitLine

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
0.44 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
0.788 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

L-Arginine

Interacts with
403 drugs
396 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

L-Citrulline

Interacts with
178 drugs
58.5 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Protein

0.6 Gram(s) per serving

Folate

105 mcg DFE per serving

Other (inactive) ingredients: Grape extract, Apple extract, Capsule Shell, Inca Wheat-extract, Anti-Caking Agent, Glucose Syrup, Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Munogen by FitLine Drug Interactions

Want to check YOUR meds against Munogen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
452Drugs
439 Moderate 13 Minor

Ingredients driving the most interactions

L-Arginine 403
Vitamin B6 210
L-Citrulline 178
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in Munogen interact with 452 drugs. Click any drug to see the details.

5 of the 6 ingredients in Munogen interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Vitamin B6 L-Citrulline Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Munogen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Munogen, from the product label.

FitLine

See all FitLine products
Name
PM-International Logistics Center America, LLC
Street Address
153 Industrial Loop S.
City
Orange Park
State
FL
ZipCode
32073
Web Address
www.fitline.com
Pharmacist Counseling Corner

Munogen by FitLine: Common Questions

Does Munogen by FitLine interact with any medications?
Yes. Based on its ingredients, Munogen has a known interaction with 452 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Munogen contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
Folic acid in Munogen is recommended during pregnancy at standard prenatal doses to help prevent birth defects. However, L-citrulline's safety in pregnancy is not well established, and the facts advise avoiding it. There's incomplete data for L-arginine in pregnancy. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
Folic acid and vitamin B12 are considered safe at normal recommended amounts while breastfeeding. L-citrulline safety while breastfeeding is unknown and the facts advise against use. L-arginine's safety data isn't on file. Your pharmacist or doctor can help you decide whether this product fits your situation.
What does folic acid in this supplement do?
Folic acid is a B vitamin that supports cell division and is used to prevent birth defects, treat folate deficiency, and help reduce side effects from methotrexate treatment. It's also possibly effective for depression and brain health.
I take metformin for diabetes. Is it okay to use this?
Vitamin B12 has a minor interaction with metformin—prolonged use of metformin can lower B12 levels. More importantly, L-arginine in this product may lower blood sugar and could add to metformin's effects, raising your low-blood-sugar risk. Check with your pharmacist before starting.
What side effects might I notice?
At recommended doses, folic acid and the B vitamins are well tolerated. Most common side effects are mild gastrointestinal (nausea, diarrhea, stomach discomfort), headache, or flushing. High-dose folic acid or vitamin B6 can cause neuropathy or sleep problems. Contact your pharmacist if new symptoms appear.
What is L-citrulline used for in this product?
L-citrulline is an amino acid your body converts to L-arginine, which widens blood vessels. The evidence we hold shows it's possibly effective for athletic performance but insufficient for heart disease or diabetes support.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Munogen label
Go deeper

The Full Monographs Behind Munogen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph →
Sources

Sources & How We Checked

Munogen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 192 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
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Vitamin B12 30 references
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L-citrulline 8 references
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