Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Natural Calcium Formula Ingredients & Drug Interactions

by CATALO

Natural Calcium Formula label
See full label image
Capsule Category: Mineral
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Calcium Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Natural Calcium Formula is a dietary supplement by CATALO with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 370 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Carribean Coral Calcium, Natural, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Natural Calcium Formula by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Calcium Formula by CATALO — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Natural Calcium Formula by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Carribean Coral Calcium, Natural, Powder” is listed as a grouped ingredient — the label gives one combined amount (750 mg) without saying how much of each component you get.

Natural Calcium Formula contains 4 active ingredients: calcium (from Aquamin and Caribbean Coral Calcium, Natural, Powder), magnesium, and iron. These minerals work together to support bone health and address mineral deficiencies.

The product also contains inactive ingredients — cellulose, pullulan, magnesium stearate, and silicon dioxide — which are binders and capsule materials. Calcium is the primary mineral here, playing a key role in bone strength and a number of other body functions.

Magnesium and iron round out the formula as supporting minerals with their own roles in metabolism and oxygen transport.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Strengthen bone health and reduce bone loss.
  • We looked for evidence on: Corticosteroid-induced osteoporosis, Fall prevention, Fractures, Hypocalcemia, Fetal bone mineralization, Osteoporosis — and 2 related terms.
  • The strongest evidence on file: Calcium is rated "Effective" for Hypocalcemia (Natural Medicines).
  • Also on file: Calcium is rated "Likely Effective" for Corticosteroid-induced osteoporosis, Osteoporosis.
  • Also on file: Calcium is rated "Possibly Effective" for Fetal bone mineralization.

Calcium in this formula is effective for kidney failure, indigestion (dyspepsia), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and likely effective for osteoporosis. Magnesium is effective for indigestion and constipation, and also for low blood magnesium (hypomagnesemia) and pre-eclampsia in pregnancy.

Iron is effective for iron deficiency anemia and anemia of chronic disease, and possibly effective for heart failure. The evidence supporting these uses comes from clinical data we hold; however, whether this particular formulation at its dose will work for your situation is something to discuss with your doctor or pharmacist.

The evidence, ingredient by ingredient Calcium Magnesium Iron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium, magnesium, and iron are generally well tolerated when taken at recommended doses. The most common side effects are mild: belching, constipation, diarrhea, nausea, and stomach upset.

Serious side effects are rare but have been reported in case studies — calcium may increase the risk of kidney stones or, at very high doses, prostate cancer (over 1500–2000 mg daily of calcium), and there is some concern about an increased risk of heart disease with high calcium intake. Magnesium at very high doses has been associated with decreased bone mass, and iron at high doses can cause serious toxicity.

In pregnancy, calcium and adequate magnesium intake are important; use only the recommended amounts unless your doctor advises otherwise. Iron is often recommended in pregnancy but should be dosed under prenatal care guidance.

For breastfeeding, calcium and magnesium at normal dietary amounts are considered appropriate; check with your provider before using supplements. We have no data on whether iron during breastfeeding is safe, so discuss this with your healthcare provider.

Side effects, ingredient by ingredient Calcium Magnesium Iron

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Calcium, Iron, Magnesium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 370 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before taking this product if you use HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), intravenous ceftriaxone, thyroid medication (levothyroxine), heart rhythm drugs (sotalol), Parkinson's medication (levodopa/carbidopa), blood pressure drugs (diltiazem, methyldopa, calcium channel blockers), skeletal muscle relaxants, potassium-sparing diuretics, diabetes drugs (sulfonylureas), antibiotics (quinolones, tetracyclines), bone drugs (bisphosphonates), psoriasis treatment (calcipotriene), or any other prescription medication — magnesium and iron also interact with several others. Separation of doses by 2 to 6 hours is often needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This formula is useful if you have a mineral deficiency or need bone support — talk with your doctor about whether you actually need supplementation. If you take any prescription medications, especially HIV drugs, thyroid medication, heart drugs, antibiotics, or bone medications, check them against the interaction tool before starting.

Magnesium and iron need timing separation from some medications, so dosing matters. Run through your personal list with your own doctor or pharmacist before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Calcium Formula, straight from the product label.

Brand CATALO
Net contents 60 Capsule(s); 51 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303109
Product type Mineral
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Pregnant Women, Seniors/Mature (>50 Years), Lactating
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Calcium Formula by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
20
IngredientAmount% DV
Aquamin750 mg--
Carribean Coral Calcium, Natural, Powder750 mg--
Calcium495 mg--
Magnesium18 mg--
Iron0.3 mg--

Other ingredients: Cellulose, Pullulan, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Clinically proven enhance bone health

Main functions: Strengthen bone tissue and structure Improve bone density and tenacity Reduce bone loss Relieve joint pain and promote mobility

Made in USA

This product is made from natural sources and may have color variation. This is a normal phenomenon and does not affect product quality.

FDA Statement of Identity

Dietary Supplement

Dietary Supplement

Formula

CATALO Natural Calcium Formula contains algae calcium and natural Carribean coral calcium harvested from the unpolluted marine coral fossils. It is highly absorbable because of its natural ability to become ionic upon contact with moisture. CATALO Natural Calcium Formula also helps to reduce the risk of bone loss and improves overall bone density. It has good bioavailability that can be easily absorbed by our body. Encapsulated in a vegetarian capsule which is suitable for everyone. With clinically proven efficacy to enhance bone health, algae calcium helps to relieve joint mobility. Its beehive-like structure can further enhance bone development as it will be immediately dissolved in the digestive system and quickly absorbed. Natural Caribbean corral calcium contains natural minerals and trace elements which are the key ingredients to replenish nutrients for maintaining healthy bones and balance body's pH level. Its high bioavailability encourages higher absorption by the body. 1. Shea, K.L., et al, (2014) Medicine & Science in Sport & Exercise, 46(10), 2007-2013 2. Frestedt, J.L., et al. (2008) Nutrition Journal, 7(9) (1 & 2 refer to Aquamin Algae Calcium Powder)

Suitable for: Children 6 years old or above, teenagers, adults, elderly, pregnant and lactating women, concerned about bone health

Brand IP Statement(s)

Aquamin Aquamin is a trademark of Marigot Ltd.

Seals/Symbols

cGMP Current Good Manufacturing Practices Quality Efficacy Natural Potency Safety

Suggested/Recommended/Usage/Directions

Serving directions For age 6-11, take 1 capsule daily. For age 12 or above, take 3 capsules daily. For pregnant and lactating women, take 3 capsules daily. Take after meal. Consume directly or open the capsule and mix with foods (e.g. soup, milk, congee) for easier consumption

Storage

Storage Keep in a dry and cool place Avoid direct sunlight

General Statements

Net weight 51 g (850 mg x 60 capsules)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Calcium Formula by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Calcium Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Calcium Formula by CATALO

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aquamin

750 mg per serving Form: Algae Calcium, Powder

Carribean Coral Calcium, Natural, Powder

Interacts with
168 drugs
750 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Carribean Coral Calcium, Natural, Powder monograph & interactions

Other (inactive) ingredients: Cellulose, Pullulan, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Calcium Formula by CATALO Drug Interactions

Want to check YOUR meds against Natural Calcium Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
13 Major 243 Moderate 114 Minor

Ingredients driving the most interactions

Carribean Coral Calcium, Natural, Powder 168

Individual Drug Interactions

The ingredients in Natural Calcium Formula interact with 370 drugs. Click any drug to see the details.

1 of the 2 ingredients in Natural Calcium Formula interact with drugs. Each result below shows which ingredient is responsible. Carribean Coral Calcium, Natural, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Calcium Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Carribean Coral Calcium, Natural, Powder18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Carribean Coral Calcium, Natural, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Calcium Formula, from the product label.

CATALO

See all CATALO products
Name
CATALO
Phone Number
(852) 3556 8686
Web Address
CATALO.com
Pharmacist Counseling Corner

Natural Calcium Formula by CATALO: Common Questions

Does Natural Calcium Formula by CATALO interact with any medications?
Yes. Based on its ingredients, Natural Calcium Formula has a known interaction with 370 medications, including 13 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Calcium Formula contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant?
Calcium is likely safe in pregnancy at recommended amounts — in fact, adequate calcium is important during pregnancy. Magnesium is needed in pregnancy too, but use supplements only under your doctor's guidance. Iron is often recommended in pregnancy; your prenatal care provider should guide your dose. Talk with your doctor about whether you need this formula and at what dose.
What's Aquamin?
Aquamin is one of the calcium sources in this formula, derived from a marine plant. We hold no interaction data for it, so we cannot check whether it interacts with medications. The other ingredients — calcium, magnesium, and iron — we can check.
Can this help with osteoporosis?
Calcium in this formula is likely effective for osteoporosis. However, bone health depends on more than one supplement — weight-bearing exercise, adequate vitamin D, and overall diet all matter. Talk with your doctor about whether this product is right for your situation.
What side effects might I notice?
The most common side effects are mild — belching, constipation, diarrhea, nausea, and stomach upset. Serious side effects are rare but have been reported. If you experience severe or persistent symptoms, stop and talk with your pharmacist or doctor.
How far apart do I need to take this from my other medications?
It depends on your specific medications. Calcium, magnesium, and iron can all form complexes that reduce absorption of certain drugs — sometimes 2 hours apart is enough, sometimes you need 4 to 6 hours. Use the interaction checker on this page with your exact medications, and confirm the timing with your pharmacist or doctor.
Is this safe for breastfeeding?
Calcium and magnesium at recommended amounts are considered appropriate during breastfeeding. We have no data on the safety of iron during breastfeeding, so check with your provider before using this formula while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Calcium Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Calcium Formula label
Go deeper

The Full Monographs Behind Natural Calcium Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph →
Sources

Sources & How We Checked

Natural Calcium Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 216 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  24. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
  25. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
  27. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
  28. Tavani A, Bertuccio P, Bosetti C, et al. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 2005;48:27-33. PubMed
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Magnesium 82 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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