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Dietary supplement

Phenylethylamine HCL 150 mg Ingredients & Drug Interactions

by BulkSupplements.com

Phenylethylamine HCL 150 mg label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phenylethylamine HCL 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phenylethylamine HCL 150 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for mood support, focus and concentration, energy and pre-workout boost.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phenylethylamine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phenylethylamine HCL 150 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Phenylethylamine HCL 150 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phenylethylamine HCL 150 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phenylethylamine hydrochloride at 150 mg per serving. Phenethylamine is a compound your brain naturally makes in small amounts; it plays a role in mood, focus, and how your nervous system works.

There are no inactive ingredients listed for this powder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Phenethylamine (pea) product and its label doesn't state a use — see Phenethylamine (pea)'s own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that phenethylamine is effective for athletic performance, depression, or weight management. The data on these uses is rated insufficient reliable evidence — which means the research either isn't there yet, isn't strong enough, or is too limited to draw firm conclusions.

If you're considering this for one of those reasons, talk with your pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Phenethylamine (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phenethylamine may affect your heart rate and blood pressure, and safety data in humans is limited — that's an important caution because we don't have a large body of real-world safety information. Two case reports mention anxiety, agitation, and rapid heartbeat in people taking multi-ingredient weight-loss products that contained phenethylamine, though it's unclear whether phenethylamine alone was responsible since those products had many other active ingredients.

The safety information available advises against use during pregnancy and while breastfeeding due to insufficient data to know either way.

Side effects, ingredient by ingredient Phenethylamine (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenethylamine (pea).
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you're on serotonergic drugs — antidepressants (SSRIs, SNRIs, tricyclics), migraine medications (triptans), certain pain relievers, or any MAOI. These are Moderate-severity interactions that need a conversation first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phenethylamine HCL is a single-ingredient supplement with a narrow safety window and real drug interactions, mainly with antidepressants and older antidepressant classes. If you take any medication that affects serotonin or are on an MAOI, you need to check before starting.

Talk with your pharmacist about whether this product is right for you and your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phenylethylamine HCL 150 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HHSYQJ
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 330239
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phenylethylamine HCL 150 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
150 mg
Maximum serving Sizes:
150 mg
Servings per container
1667
UPC/BARCODE
X000HHSYQJ
IngredientAmount% DV
Phenylethylamine Hydrochloride150 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

PEA Phenylethylamine HCL 150 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formulation

Free of: Added sugar, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 150 mg once daily, or as directed by a physician. Individual needs may vary.

Precautions

Do not exceed recommended dose.

Phenylketonurics: Contains phenylalanine

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

General Statements

Use an accurate milligram scale.

New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phenylethylamine HCL 150 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phenylethylamine HCL 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phenylethylamine HCL 150 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size150 mg Dosage formPowder Servings per container1667 Amounts shown are per serving.

Phenylethylamine Hydrochloride

Interacts with
187 drugs
150 mg per serving

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. R...

Phenylethylamine Hydrochloride monograph & interactions
Interaction report

Phenylethylamine HCL 150 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Phenylethylamine HCL 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Phenylethylamine Hydrochloride 187

Individual Drug Interactions

The ingredients in Phenylethylamine HCL 150 mg interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phenylethylamine HCL 150 mg interact with drugs. Each result below shows which ingredient is responsible. Phenylethylamine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Phenylethylamine HCL 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phenylethylamine Hydrochloride2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
Phenylethylamine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phenylethylamine HCL 150 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Phenylethylamine HCL 150 mg by BulkSupplements.com: Common Questions

Does Phenylethylamine HCL 150 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Phenylethylamine HCL 150 mg has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phenylethylamine HCL 150 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take phenethylamine if I'm on an antidepressant?
Not without checking with your pharmacist first. Combining phenethylamine with serotonergic antidepressants may increase the risk of serotonergic side effects because phenethylamine raises serotonin levels in the brain. This is a Moderate-severity interaction that needs personalized advice.
What does phenethylamine actually do?
It's a compound your brain naturally produces that influences mood, focus, and nervous system function. Animal research shows it increases serotonin, norepinephrine, and dopamine levels, but the effectiveness data we hold doesn't establish that the supplement itself works for depression, athletic performance, or weight loss in humans.
Are there side effects?
Phenethylamine may affect heart rate and blood pressure. Two case reports describe anxiety, agitation, and rapid heartbeat from products containing phenethylamine, though those products had multiple ingredients so it's unclear what caused the effects. Human safety data is limited overall.
Is it safe during pregnancy or breastfeeding?
The safety data advises against use in both pregnancy and breastfeeding because there isn't enough information to know either way. Talk with your doctor or pharmacist for personalized advice if you're considering it during these times.
Does this product have fillers or other ingredients?
No — this is a pure phenethylamine powder with no listed inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phenylethylamine HCL 150 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phenylethylamine HCL 150 mg label
Go deeper

The Full Monographs Behind Phenylethylamine HCL 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph →
Sources

Sources & How We Checked

Phenylethylamine HCL 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenethylamine (pea) 9 references
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

See these in context on the Phenethylamine (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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