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Dietary supplement

Sceletium Ingredients & Drug Interactions

by Big Tree

Sceletium label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sceletium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sceletium is a dietary supplement by Big Tree with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, low mood, mental focus and cognition.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sceletium tortuosum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sceletium by Big Tree

Ask about any prescription or over-the-counter medication and we check it for interactions with Sceletium by Big Tree — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sceletium by Big Tree

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Big Tree Sceletium is a single-ingredient tablet containing sceletium tortuosum, a plant extract. The tablet also contains inactive ingredients (microcrystalline cellulose, potato starch, silicon dioxide, and magnesium stearate) that help form and stabilize the pill.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sceletium product and its label doesn't state a use — see Sceletium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for sceletium isn't established in our data. We hold insufficient reliable evidence to rate it for anxiety, depression, stress, alcohol use disorder, athletic performance, or weight management.

That doesn't mean it doesn't work—it means the studies we have aren't strong or complete enough yet to say.

The evidence, ingredient by ingredient Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sceletium appears generally well tolerated in small studies, but we don't have good long-term safety data. The most common side effects reported with oral use are anxiety, headache, insomnia, irritability, and nausea.

There are also anecdotal reports of headache, depression, and listlessness with chewing, and a report of elevated blood pressure. The safety data advises against use during pregnancy.

Safety data are also lacking for breastfeeding, so avoid it then too. Because our overall safety information is limited, talk with your pharmacist or doctor before starting, especially if you have any health conditions.

Side effects, ingredient by ingredient Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Big Tree Sceletium, double-check any CNS depressants you're on—that includes prescription sedatives, sleep aids, opioid pain relievers, anti-anxiety medications, and some antidepressants. The risk is moderate: additive sedation.

Use the medication checker on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sceletium might interest you if you're exploring options for stress or anxiety, but the evidence for it isn't established yet. The main caution: don't combine it with sedatives, sleep aids, opioids, or anxiety medications without checking first—the drowsiness could compound.

Pregnancy and breastfeeding are off-limits. Run your exact medications through our checker, and talk to your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sceletium, straight from the product label.

Brand Big Tree
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Dec 21, 2012
DSLD ID 17038
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegan, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sceletium by Big Tree, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
IngredientAmount% DV
Sceletium tortuosum50 mg--

Other ingredients: Microcrystalline Cellulose, Potato Starch, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: 1 tablet twice daily or as directed by a healthcare practitioner.

Precautions

Do not use during pregnancy or while breastfeeding.

Keep out of reach of children.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

General Statements

Please recycle.

See underside for batch number and expiry date.

Formulation

*Organically grown without the use of synthetic pesticides, herbicides or chemical fertilizers.

Pesticide residue free.

Free of corn, yeast, wheat, soy, salt, sugar and dairy products and formulated without preservatives, artificial colours or flavours.

Suitable for vegans.

Formula

Sceletium tortuosum

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sceletium by Big Tree label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sceletium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sceletium by Big Tree

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Sceletium tortuosum

Interacts with
248 drugs
50 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Sceletium tortuosum monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Potato Starch, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sceletium by Big Tree Drug Interactions

Want to check YOUR meds against Sceletium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Sceletium tortuosum 248

Individual Drug Interactions

The ingredients in Sceletium interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sceletium interact with drugs. Each result below shows which ingredient is responsible. Sceletium tortuosum

Each ingredient & the kinds of drugs it affects

For each ingredient in Sceletium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sceletium tortuosum1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Sceletium tortuosum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sceletium, from the product label.

Big Tree

See all Big Tree products
Name
Big Tree Nutraceutical
Street Address
PO Box 889
City
Wilderness
ZipCode
6560
Pharmacist Counseling Corner

Sceletium by Big Tree: Common Questions

Does Sceletium by Big Tree interact with any medications?
Yes. Based on its ingredients, Sceletium has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sceletium contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is sceletium tortuosum?
Sceletium tortuosum is a plant extract used in this supplement. It appears to have sedative properties, which is why it's sometimes explored for stress and anxiety, though the evidence for those uses isn't established yet.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advise against sceletium during pregnancy, and safety information is lacking for breastfeeding, so it's best avoided then too. Talk with your doctor or pharmacist about your specific situation.
What side effects might I notice?
The most common ones reported with oral use are anxiety, headache, insomnia, irritability, and nausea. There are also anecdotal reports of elevated blood pressure. Keep in mind that overall safety data on sceletium are limited.
Is sceletium proven to work for anxiety or depression?
Not yet, based on the evidence we hold. We have insufficient reliable evidence to rate it for anxiety, depression, stress, or several other uses. That doesn't mean it won't help you—just that the research isn't there yet.
Can I take this with my sleep medication?
Not without checking first. Sceletium has sedative properties, so combining it with sleep aids or other CNS depressants could make you too drowsy. Run your specific medication through our checker on this page, and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sceletium is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sceletium label
Go deeper

The Full Monographs Behind Sceletium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Sceletium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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