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Dietary supplement

Kanna Ingredients & Drug Interactions

by Everyday Health

Kanna label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kanna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kanna is a dietary supplement by Everyday Health with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, low mood, mental focus and cognition.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Kanna Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kanna by Everyday Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Kanna by Everyday Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kanna by Everyday Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Kanna Extract, a concentrated form of sceletium. The capsule is made with gelatin as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sceletium's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Natural mood support.
  • We looked for evidence on: Anxiety, Depression, Stress, Low mood, Mood enhancement.
  • The closest evidence on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Depression, Stress.

The evidence for kanna isn't established yet. The data we hold shows insufficient reliable evidence to rate it for anxiety, depression, stress, alcohol use disorder, obesity, or athletic performance.

If you're considering it for any of these uses, the science doesn't support a clear benefit at this point.

The evidence, ingredient by ingredient Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Kanna appears generally well tolerated in small studies, but long-term safety isn't well established. The most commonly reported side effects in trials are anxiety, headache, insomnia, irritability, and nausea.

There are also anecdotal reports of headache, depression, and listlessness, as well as reports of high blood pressure and euphoric effects at higher doses. The safety data advises against use during pregnancy and while breastfeeding.

There isn't enough information to know whether kanna is safe in these situations, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Kanna, double-check any CNS depressants you're on—that includes sleep aids, anti-anxiety drugs, opioid painkillers, muscle relaxers, and antihistamines that cause drowsiness. The combination could enhance sedative effects.

Talk with your doctor or pharmacist about whether it's safe for you to add this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Kanna might appeal to you if you're exploring options for stress or anxiety, but the evidence for it isn't strong enough yet to say it works. The main caution is if you take any sedating medication—you'll want to check with your doctor or pharmacist first, because combining them could make drowsiness worse.

Long-term safety isn't clear, so if you're thinking about using it regularly, that's worth discussing with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kanna, straight from the product label.

Brand Everyday Health
Barcode (UPC) 9421902427343
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 306087
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kanna by Everyday Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
9421902427343
IngredientAmount% DV
Kanna Extract500 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural mood support

Made in New Zealand from imported ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule once or twice daily as required, or as advised by your doctor.

Precautions

Warning: Never use in combination with common psychiatric medications including SSRIs (such as Prozac) and MAO Inhibitors. If you suffer from any illness or on medication consult with your doctor first.

Seals/Symbols

GMP Certified Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kanna by Everyday Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kanna label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kanna by Everyday Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Kanna Extract

Interacts with
248 drugs
500 mg per serving Form: Sceletium tortuosum Extract

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Kanna Extract monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kanna by Everyday Health Drug Interactions

Want to check YOUR meds against Kanna?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Kanna Extract 248

Individual Drug Interactions

The ingredients in Kanna interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Kanna interact with drugs. Each result below shows which ingredient is responsible. Kanna Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Kanna with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Kanna Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Kanna Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kanna, from the product label.

Everyday Health

See all Everyday Health products
Name
Everyday Health Ltd
Street Address
3, 1 Kingsford Smith Drive
City
Rangiora
Phone Number
0800 773 766
Web Address
www.everydayhealth.nz
Pharmacist Counseling Corner

Kanna by Everyday Health: Common Questions

Does Kanna by Everyday Health interact with any medications?
Yes. Based on its ingredients, Kanna has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kanna contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Kanna if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe. Talk with your doctor or pharmacist about your situation before taking it.
What side effects might I experience?
The most commonly reported side effects are anxiety, headache, insomnia, irritability, and nausea. There are also anecdotal reports of depression, listlessness, and high blood pressure. At higher doses, some people report euphoric effects. Overall, safety information is limited and long-term effects aren't well studied.
Does Kanna actually work for anxiety or stress?
The evidence isn't established yet. We have insufficient reliable evidence to rate it for anxiety, depression, stress, or other uses listed here. That doesn't mean it won't help, just that the science hasn't proven it clearly enough at this point.
What is Kanna Extract?
Kanna Extract is a concentrated form of sceletium, a plant. Some evidence suggests it has sedative properties, which is why it's important not to combine it with other drugs that slow brain activity without checking with your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kanna is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kanna label
Go deeper

The Full Monographs Behind Kanna’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Kanna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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