Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Spirulina Ingredients & Drug Interactions

by ZHOU

Spirulina label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spirulina against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Spirulina is a dietary supplement by ZHOU with 5 active ingredients. Its ingredients are commonly taken for general nutrition and energy, antioxidant support, cholesterol and metabolic health.Based on those ingredients, 708 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are California grown Spirulina, Iron, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Spirulina by ZHOU

Ask about any prescription or over-the-counter medication and we check it for interactions with Spirulina by ZHOU — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Spirulina by ZHOU

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “California grown Spirulina” is listed as a grouped ingredient — the label gives one combined amount (3.50 Gram(s)) without saying how much of each component you get.

ZHOU Spirulina powder contains seven active ingredients. The main ingredient is California-grown spirulina itself—a blue-green algae—along with zeaxanthin and chlorophyll (both natural pigments), gamma-linolenic acid (an omega-6 fatty acid), phycocyanin (a spirulina protein), vitamin K, iron, and potassium.

The only inactive ingredient listed is spirulina itself. These components work together as the nutrient profile of the algae blend.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Powerful antioxidant and immune system support.
  • We looked for evidence on: Cardiovascular disease (CVD), Dyslipidemia, Hyperlipidemia, Hypertension, Iron deficiency anemia, Immune function — and 2 related terms.
  • The strongest evidence on file: Iron is rated "Effective" for Iron deficiency anemia (Natural Medicines).
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).
  • Also on file: Zeaxanthin is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia.

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), an eye condition that can affect vision as you age. We don't have reliable evidence yet for zeaxanthin in age-related cognitive decline, Alzheimer's disease, asthma, breast cancer, or bronchopulmonary dysplasia.

Chlorophyll, iron, and potassium have no established effectiveness ratings in our data. Gamma-linolenic acid and phycocyanin effectiveness data isn't on file.

Vitamin K is effective for certain clotting and bleeding disorders, and possibly effective for osteoporosis.

The evidence, ingredient by ingredient Blue-green Algae Zeaxanthin Chlorophyll Vitamin K Iron Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at typical supplement amounts, though concentrated supplement safety in pregnancy isn't well studied—dietary amounts from food are fine. Chlorophyll is generally well tolerated in short-term use, but high-quality safety data are limited; it should be avoided in pregnancy and breastfeeding due to insufficient safety information.

Iron is generally safe at recommended doses, though excess iron can be toxic; it's often used in pregnancy under your prenatal care provider's guidance and is generally acceptable while breastfeeding at appropriate doses. Vitamin K is generally safe in food and most supplements for healthy people; check with your doctor before taking supplements.

Potassium from food is generally safe, but supplements can cause dangerously high blood levels in some people, especially those with kidney disease. Pregnancy and lactation safety data for gamma-linolenic acid, phycocyanin, and the full spirulina blend isn't on file.

Common side effects from iron include abdominal pain, constipation, diarrhea, nausea, and vomiting. Chlorophyll may cause photosensitization (skin sensitivity to sun).

Potassium may cause abdominal pain, diarrhea, nausea, and vomiting.

Side effects, ingredient by ingredient Blue-green Algae Zeaxanthin Chlorophyll Vitamin K Iron Potassium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Chlorophyll, Potassium, Iron, Vitamin K, Zeaxanthin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 496 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications against this product if you take warfarin or other blood thinners (Major severity); photosensitizing drugs, methotrexate, any antibiotics, thyroid medication, bisphosphonates, blood pressure medications including ACE inhibitors or ARBs, heart medications, levothyroxine, methyldopa, mycophenolate mofetil, or penicillamine (all Moderate severity). Discuss timing and dosing with your pharmacist or doctor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

ZHOU Spirulina might appeal to someone looking for zeaxanthin for eye health or seeking the general nutrient profile of spirulina. If you take warfarin, any blood pressure or heart failure medications, antibiotics, thyroid medication, antidiabetes drugs, or drugs for Parkinson's disease, you'll want to check with your doctor or pharmacist before starting this product.

Talk over this supplement with your own healthcare provider before adding it to what you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spirulina, straight from the product label.

Brand ZHOU
Barcode (UPC) 859805006324
Net contents 6 Ounce(s); 170 Gram(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250129
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spirulina by ZHOU, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.5 Gram(s)
Maximum serving Sizes:
3.5 Gram(s)
Servings per container
48
UPC/BARCODE
859805006324
IngredientAmount% DV
Calories15 Calorie(s)--
Zeaxanthin3 mg--
Chlorophyll31 mg--
Gamma-Linolenic Acid46 mg--
Phycocyanin350 mg--
California grown Spirulina3.5 Gram(s)--
Protein2 mg4%
Vitamin K30 mcg25%
Iron2 mg11%
Potassium55 mg1%

Other ingredients: 100% Spirulina

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Greatness by Nature

This product is packaged by weight, not by volume. Settling of contents occurs over time.

Long live you #howizhou Facebook Instagram

Formulation

Sustainably grown in California Powerful antioxidant and immune system formula

California grown Longevity superfood

Energy and vitality support

Pesticides & herbicides free Made with Non-GMO ingredients Zero pesticides, herbicides, soy, milk, eggs, fish, shellfish, tree nuts, peanuts, wheat

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 scoop (3.5 g) daily with or between meals. Enjoy mixing into juices, smoothies, or other favorite recipes.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Consistent quality Pesticides & herbicides free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spirulina by ZHOU label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spirulina label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spirulina by ZHOU

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3.5 Gram(s) Dosage formPowder Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

California grown Spirulina

Interacts with
327 drugs
3.5 Gram(s) per serving

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

California grown Spirulina monograph & interactions

Protein

2 mg per serving Form: Spirulina

Vitamin K

Interacts with
2 drugs
30 mcg per serving Form: Spirulina

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K monograph & interactions

Iron

Interacts with
80 drugs
2 mg per serving Form: Spirulina

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Potassium

Interacts with
62 drugs
55 mg per serving Form: Spirulina

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: 100% Spirulina. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spirulina by ZHOU Drug Interactions

Want to check YOUR meds against Spirulina?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
708Drugs
2 Major 705 Moderate 1 Minor

Ingredients driving the most interactions

California grown Spirulina 327
Iron 80
Potassium 62
Vitamin K 2

Individual Drug Interactions

The ingredients in Spirulina interact with 708 drugs. Click any drug to see the details.

4 of the 5 ingredients in Spirulina interact with drugs. Each result below shows which ingredient is responsible. California grown Spirulina Iron Potassium Vitamin K

Each ingredient & the kinds of drugs it affects

For each ingredient in Spirulina with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

California grown Spirulina3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
California grown Spirulina full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Vitamin K1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spirulina, from the product label.

ZHOU

See all ZHOU products
Name
ZHOU Nutrition Zhou, Inc.
City
Park City
State
UT
ZipCode
84098
Phone Number
1-855-700-9468
Web Address
zhounutrition.com
Pharmacist Counseling Corner

Spirulina by ZHOU: Common Questions

Does Spirulina by ZHOU interact with any medications?
Yes. Based on its ingredients, Spirulina has a known interaction with 708 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spirulina contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this spirulina safe during pregnancy?
Zeaxanthin, a component of this product, is likely safe in pregnancy, though concentrated supplement safety isn't well studied beyond food amounts. Chlorophyll should be avoided in pregnancy. We don't have safety data on file for gamma-linolenic acid, phycocyanin, or the full spirulina blend during pregnancy. Talk with your doctor about whether this product is right for you during pregnancy.
Is this spirulina safe while breastfeeding?
Zeaxanthin and vitamin K are likely safe while breastfeeding. Chlorophyll safety during breastfeeding is unknown and should be avoided unless your doctor advises otherwise. Iron is generally considered acceptable at appropriate doses while breastfeeding, but check with your provider. We don't have breastfeeding safety data for the other ingredients, so discuss this product with your doctor.
What is zeaxanthin, and what does it do?
Zeaxanthin is a natural pigment found in spirulina and other foods. It's possibly effective for age-related macular degeneration (AMD), an eye condition that can affect your vision as you get older. We don't have strong evidence yet for other uses.
Can I take this if I'm on warfarin for blood clots?
No—you should not take this product without talking to your doctor first. Vitamin K in this spirulina can reverse warfarin's ability to thin your blood and prevent clots. This is a major interaction. Check with your doctor or pharmacist before adding any supplement.
What side effects does iron in this product cause?
The most common side effects from iron are abdominal pain, constipation, diarrhea, nausea, and vomiting. These are usually mild. Serious side effects are rare but can include ulcers in the stomach or intestines.
Does this spirulina actually work for anything?
Zeaxanthin in this product is possibly effective for age-related macular degeneration, an eye condition. Vitamin K is effective for certain clotting and bleeding disorders and possibly effective for osteoporosis. For the other ingredients and the spirulina blend as a whole, we don't have reliable evidence yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spirulina label
Go deeper

The Full Monographs Behind Spirulina’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Spirulina's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Blue-green Algae 22 references
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
  3. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
  4. Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
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See these in context on the Blue-green Algae monograph →

Vitamin K 11 references
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See these in context on the Vitamin K monograph →

Iron 72 references
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See these in context on the Iron monograph →

Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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See these in context on the Potassium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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