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Dietary supplement

TriActive Prebiotics Ingredients & Drug Interactions

by Essential Source

TriActive Prebiotics label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TriActive Prebiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TriActive Prebiotics is a dietary supplement by Essential Source with 3 active ingredients.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TriActive Prebiotics by Essential Source

Ask about any prescription or over-the-counter medication and we check it for interactions with TriActive Prebiotics by Essential Source — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TriActive Prebiotics by Essential Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Prebiotic Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.
  • “Tricelium” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

TriActive Prebiotics has five active ingredients. The Prebiotic Blend contains multiple components that promote beneficial bacteria in your gut, and it includes three mushroom extracts: Reishi, Oyster Mushroom, and Maitake.

There's also Tricelium (a group ingredient) and Inavea Pure Acacia. The capsule itself is an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune and gastrointestinal health support.
  • We looked for evidence on: Hyperlipidemia, Constipation, Gut flora balance, Intestinal barrier function.
  • The closest evidence on file: Reishi Mushroom is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The evidence we hold doesn't establish how well these ingredients work for any particular use. Reishi is rated possibly ineffective for high cholesterol (hyperlipidemia), and we don't have reliable evidence for altitude sickness, Alzheimer's disease, or athletic performance.

Maitake's evidence is also insufficient for hay fever, anemia, cancer, diarrhea, or chronic fatigue syndrome. If you're considering this product for a specific health goal, your pharmacist can help you weigh what's known.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi is generally well tolerated short-term, but long-term safety hasn't been well studied. The most common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Some people report sore throat, runny nose, insomnia, and headache. Maitake is generally well tolerated as a food, but supplement safety hasn't been fully studied.

The main side effects are gastrointestinal — diarrhea and stomach pain — and rarely, rash or allergic reactions. The safety data advises against both Reishi and Maitake during pregnancy and breastfeeding because there isn't enough data to know they're safe for you or your baby.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Maitake Mushroom, Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take TriActive Prebiotics, check with your pharmacist if you're on blood pressure medications, blood thinners (especially warfarin), or diabetes medications. These are the drug types with Moderate interactions documented in Reishi and Maitake.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people interested in prebiotic and mushroom support who don't take blood pressure medications, blood thinners, or diabetes medications. If you're on any of those, you'll need to check with your pharmacist first — the interactions are real and could change how your drugs work.

If you're pregnant or breastfeeding, talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TriActive Prebiotics, straight from the product label.

Brand Essential Source
Barcode (UPC) 850041493015
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317926
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, No Allergies
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TriActive Prebiotics by Essential Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
850041493015
IngredientAmount% DV
Prebiotic Blend1000 mg--
Reishi0 NP--
Oyster Mushroom0 NP--
Maitake0 NP--
Tricelium0 NP--
Inavea Pure Acacia0 NP--
VitaFiber0 NP--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

TriActiv PREBiotic Advantage: Immune and GI support Support healthy cholesterol levels Heals epithelial lining of intestines Amplifies good GI flora growth Decreases bad GI flora growth Relieves constipation

Advanced prebiotic blend

Organic Certified

100% Non-GMO GFCO.org (Gluten-Free Certification Organization) Allergen free

Vegan & vegetarian

Suggested/Recommended/Usage/Directions

Suggested use: For best results take 2 to 4 capsules daily. Best taken at morning or at night before bed.

Precautions

Warning: Keep out of reach of children.

Consult your healthcare provider before taking if you are pregnant or nursing, taking other medications, suffering from a medical condition, or have any other medical concerns.

Formula

Tricelium (Organic mushroom blend) Inavea (pure organic acacia) VitaFiber (Organic tapioca)

EarthKosher

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Tricelium is a trademark of NutriScience Innovations, LLC

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization) EarthKosher

GMP Good Manufacturing Practice Consistent Quality

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TriActive Prebiotics by Essential Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TriActive Prebiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TriActive Prebiotics by Essential Source

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Prebiotic Blend

1000 mg per serving
  • › Tricelium

Inavea Pure Acacia

0 NP per serving

VitaFiber

0 NP per serving Form: Tapioca Starch

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

TriActive Prebiotics by Essential Source Drug Interactions

Want to check YOUR meds against TriActive Prebiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in TriActive Prebiotics interact with 375 drugs. Click any drug to see the details.

0 of the 3 ingredients in TriActive Prebiotics interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in TriActive Prebiotics with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for TriActive Prebiotics, from the product label.

Essential Source

See all Essential Source products
Name
Essential Source, Inc.
Street Address
625 W. Deer Valley Road Suite 103-152
City
Phoenix
State
AZ
ZipCode
85027
Pharmacist Counseling Corner

TriActive Prebiotics by Essential Source: Common Questions

Does TriActive Prebiotics by Essential Source interact with any medications?
Yes. Based on its ingredients, TriActive Prebiotics has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TriActive Prebiotics contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Both Reishi and Maitake can lower blood pressure, so combining them with your medication might drop your pressure too low. Talk with your pharmacist about your specific drugs before starting — they can advise whether it's safe or if you need monitoring.
What are the main side effects?
The mushroom ingredients are generally well tolerated, but you might notice dizziness, dry mouth, nausea, stomach upset, rash, or itching. Gastrointestinal effects like diarrhea are also reported. Stop and call your pharmacist if anything concerns you.
Can I take this while pregnant or breastfeeding?
The safety data advises against both Reishi and Maitake during pregnancy and breastfeeding because there isn't enough data to know they're safe. Talk with your doctor or pharmacist about your options.
Is this safe to use long-term?
Reishi is generally well tolerated in the short term, but long-term safety hasn't been well studied. Maitake's supplement safety also hasn't been fully researched. If you're planning to take this for months, check in with your pharmacist.
Will this really help my digestion or immunity?
The evidence we hold doesn't establish how well these ingredients work for digestive health or immune support. The effectiveness data is either insufficient or not rated for the conditions we have on file.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TriActive Prebiotics is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TriActive Prebiotics label
Sources

Sources & How We Checked

TriActive Prebiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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