Interactions on record — worth a quick check against your medications. Based on 5 of 10 ingredients. Check your meds →
Dietary supplement

UriVArx Ingredients & Drug Interactions

by Innovus Pharmaceuticals

UriVArx label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking UriVArx against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

UriVArx is a dietary supplement by Innovus Pharmaceuticals with 10 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,465 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Tree Peony Root Bark Extract, Cinnamon bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against UriVArx by Innovus Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with UriVArx by Innovus Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of UriVArx by Innovus Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

UriVArx contains 10 ingredients total, of which we can identify the active components: Bioperine (black pepper extract), Tree Peony Root Bark Extract, Cinnamon bark extract, Rehmannia Root Extract, and Hoelen Fruiting Body Extract (a medicinal mushroom). The other five active ingredients — Achyranthes Root Extract, Chinese Yam rhizome extract, Alisma Rhizome Extract, Corni Fructus Fruit Extract, and Plantaginis Semen Seed Extract — are traditional herbal ingredients.

The capsule also contains inactive ingredients including gelatin, silicon dioxide, magnesium stearate, and microcrystalline cellulose, which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote and support healthy bladder function.
  • We looked for evidence on: Urinary incontinence, Urinary tract infections (UTIs), overactive bladder, urinary frequency, bladder control.
  • The closest evidence on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Urinary incontinence.

The evidence for UriVArx's active ingredients is limited. For Bioperine (black pepper), the data we hold shows insufficient evidence for hay fever, asthma, athletic performance, headache, depression, and diarrhea.

Tree Peony has insufficient evidence for aging skin, anal fissures, atherosclerosis, chronic fatigue, cirrhosis, and migraine — though human studies remain sparse. Cinnamon bark extract similarly lacks established evidence for amenorrhea, angina, common cold, diabetes, diarrhea, and abnormal cholesterol levels.

Rehmannia shows possibly effective evidence for chronic kidney disease, but insufficient evidence for aplastic anemia, allergies, osteoporosis, diabetes, and diabetic kidney disease. The remaining ingredients lack established effectiveness ratings in our data.

Overall, the evidence base for this formula is not well established.

The evidence, ingredient by ingredient Black Pepper Peony Cassia Cinnamon Rehmannia Poria Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bioperine is generally well tolerated in food amounts and as a single medicinal dose — most common side effects are a burning aftertaste, indigestion, and reduced taste perception. Rare allergic reactions are possible in sensitive individuals.

Tree Peony is considered generally well tolerated for short-term use, though high-quality safety data are limited; it may cause gastrointestinal discomfort including abdominal bloating, loss of appetite, diarrhea, and nausea in some people — diarrhea was reported in 5% of people taking a high-dose preparation versus 1% on placebo. Cinnamon bark is generally safe in food amounts, though high doses over time may harm the liver due to its coumarin content; a rash was reported rarely in one trial, and one case of low blood sugar (hypoglycemia) seizure was reported but causality is unclear.

Rehmannia and Hoelen (poria mushroom) have limited human safety data. Poria mushroom very rarely causes allergic reactions.

The product should be avoided during pregnancy and breastfeeding due to insufficient safety information for most ingredients.

Side effects, ingredient by ingredient Black Pepper Peony Cassia Cinnamon Rehmannia Poria Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Peony, Poria Mushroom, Black Pepper, Cassia Cinnamon, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,466 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking UriVArx, check with your pharmacist if you take blood pressure medications (antihypertensives), seizure medications like phenytoin, HIV medications like nevirapine, tuberculosis drugs like rifampin, heart medications like propranolol, blood thinners or antiplatelet drugs like warfarin or aspirin, diabetes medications, theophylline (a breathing medication), antipsychotics like clozapine, estrogen or hormonal contraceptives, sedatives, or any drug metabolized by liver enzymes. All of these carry Moderate severity interactions with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

UriVArx is a traditional herbal formula with modest evidence supporting its use and several significant medication interactions you need to check first. If you take heart medications, seizure drugs, blood thinners, diabetes medications, or any psychiatric or HIV medications, run them through the checker below before starting.

Talk to your pharmacist or doctor — especially if you're pregnant or breastfeeding, or if you take medications that affect your liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about UriVArx, straight from the product label.

Brand Innovus Pharmaceuticals
Barcode (UPC) 357483002282
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 304743
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for UriVArx by Innovus Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
357483002282
IngredientAmount% DV
Bioperine15 mg--
Achyranthes Root Extract225 mg--
Tree Peony Root Bark Extract225 mg--
Chinese Yam rhizome extract225 mg--
Cinnamon bark extract75 mg--
Rehmannia Root Extract375 mg--
Alisma Rhizome Extract225 mg--
Corni Fructus Fruit Extract225 mg--
Hoelen Fruiting Body Extract225 mg--
Plantaginis Semen Seed Extract225 mg--

Other ingredients: Gelatin, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

UriVArx is a proprietary, patent pending blend of herbs designed to promote and support healthy bladder function, help reduce frequency, and maintain control.

Suggested/Recommended/Usage/Directions

Suggested use: Take three (3) capsules daily with meals or as instructed by a healthcare professional. For best results, take consistently for a minimum of 12 weeks.

Precautions

Caution: This product is intended for healthy adults.

Do not exceed the recommended amount.

Consult with a physician or healthcare professional before use especially if you have or suspect any medical condition or are taking any medications or supplements. Do not use if you are pregnant or nursing.

Discontinue use and consult a physician if you experience any unusual symptoms.

Keep out of reach of children.

Do not use if tamper evident seal around the bottle neck is missing or damaged.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Urivarx is a registered trademark of Innovus Pharmaceuticals, Inc. BioPerine is a registered trademark of Sabinsa Corp.

Formulation

Clinically proven bladder support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

UriVArx by Innovus Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

UriVArx label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in UriVArx by Innovus Pharmaceuticals

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bioperine

Interacts with
1,019 drugs
15 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

Achyranthes Root Extract

225 mg per serving

Tree Peony Root Bark Extract

Interacts with
811 drugs
225 mg per serving

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formu...

Tree Peony Root Bark Extract monograph & interactions

Chinese Yam rhizome extract

225 mg per serving

Cinnamon bark extract

Interacts with
442 drugs
75 mg per serving

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

Cinnamon bark extract monograph & interactions

Rehmannia Root Extract

Interacts with
258 drugs
375 mg per serving

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human eviden...

Rehmannia Root Extract monograph & interactions

Alisma Rhizome Extract

225 mg per serving

Corni Fructus Fruit Extract

225 mg per serving

Hoelen Fruiting Body Extract

Interacts with
417 drugs
225 mg per serving

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scient...

Hoelen Fruiting Body Extract monograph & interactions

Plantaginis Semen Seed Extract

225 mg per serving

Other (inactive) ingredients: Gelatin, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

UriVArx by Innovus Pharmaceuticals Drug Interactions

Want to check YOUR meds against UriVArx?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,465Drugs
1,465 Moderate

Ingredients driving the most interactions

Bioperine 1,019
Tree Peony Root Bark Extract 811
Cinnamon bark extract 442
Hoelen Fruiting Body Extract 417
Rehmannia Root Extract 258

Individual Drug Interactions

The ingredients in UriVArx interact with 1,465 drugs. Click any drug to see the details.

5 of the 10 ingredients in UriVArx interact with drugs. Each result below shows which ingredient is responsible. Bioperine Tree Peony Root Bark Extract Cinnamon bark extract Hoelen Fruiting Body Extract Rehmannia Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in UriVArx with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

Tree Peony Root Bark Extract7 drug types · 811 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.

Likelihood Possible Evidence D
Clozapine (Clozaril)

Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.

Likelihood Probable Evidence D
Tree Peony Root Bark Extract full monograph & interactions

Cinnamon bark extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon bark extract full monograph & interactions

Hoelen Fruiting Body Extract3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Hoelen Fruiting Body Extract full monograph & interactions

Rehmannia Root Extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for UriVArx, from the product label.

Innovus Pharmaceuticals

See all Innovus Pharmaceuticals products
Name
Innovus Pharmaceuticals, Inc.
City
Englewood
State
CO
ZipCode
80112
Phone Number
1-800-996-5122
Web Address
www.aytuhealth.com
Pharmacist Counseling Corner

UriVArx by Innovus Pharmaceuticals: Common Questions

Does UriVArx by Innovus Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, UriVArx has a known interaction with 1,465 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
UriVArx contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take UriVArx if I'm pregnant or breastfeeding?
The safety data aren't there yet for most ingredients in this product during pregnancy and breastfeeding. Tree Peony, Rehmannia, and Hoelen are specifically flagged as best avoided — there isn't enough information to know they're safe. Talk to your doctor or pharmacist for personalized advice before taking it.
What side effects might I experience from UriVArx?
The most common ones come from Bioperine: a burning aftertaste, indigestion, and reduced taste perception. Tree Peony may cause gastrointestinal upset — bloating, loss of appetite, diarrhea, or nausea — in some people. Very rarely, allergic reactions are possible. Stop and call your pharmacist if you develop a rash, difficulty breathing, or swelling.
What does each ingredient in UriVArx do?
We hold limited effectiveness data for this formula. Bioperine (black pepper) lacks proven benefits for the conditions listed in the facts. Tree Peony, Cinnamon bark, and the other ingredients are used in traditional herbal medicine, but strong human evidence for their specific effects isn't available in our data.
Is UriVArx safe for long-term use?
Safety for long-term use isn't well established. Cinnamon bark at high doses over extended periods raises concern about liver damage due to its coumarin content. Tree Peony and other ingredients lack robust long-term human safety studies. Discuss duration of use with your pharmacist.
Can Bioperine make my medications stronger?
Yes — Bioperine can increase blood levels of several medications, which may make them work more powerfully. That's why checking your exact medications with the tool on this page is essential before you start.
Does UriVArx contain any fillers?
Yes, it contains inactive ingredients: gelatin, silicon dioxide, magnesium stearate, and microcrystalline cellulose. These are standard binders and fillers in capsule supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

UriVArx label
Go deeper

The Full Monographs Behind UriVArx’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Peony

Interacts with 811 drugs

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formulas. Human evidence for most uses is lim...

Read the full Peony monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph →
Sources

Sources & How We Checked

UriVArx's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
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Cassia Cinnamon 20 references
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Rehmannia 3 references
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See these in context on the Rehmannia monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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