Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Yok3D Ingredients & Drug Interactions

by USPlabs

Yok3D label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yok3D against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Yok3D is a dietary supplement by USPlabs with 4 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 1,053 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitis Vinifera L., Vitamin C, Trichopus Zeylanicus extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Yok3D by USPlabs

Ask about any prescription or over-the-counter medication and we check it for interactions with Yok3D by USPlabs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Yok3D by USPlabs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,350 mg) without saying how much of each component you get.

Yok3D contains 4 ingredients. The active ones are Vitamin C (a nutrient and antioxidant), Arginine Nitrate (which we cannot provide details on — we hold no data), Vitis Vinifera L. (grape extract, traditionally used for circulation), and Trichopus Zeylanicus extract (an herbal ingredient with very limited safety research).

The product also includes inactive ingredients — gelatin, calcium carbonate, silicon dioxide, vegetable stearate, and several food colorings — that serve as fillers, binders, and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vitamin C deficiency — rated "Effective" (Vitamin C) (Natural Medicines).
  • On file: Anemia of chronic disease — rated "Possibly Effective" (Vitamin C) (Natural Medicines).
  • On file: Atrial fibrillation — rated "Possibly Effective" (Vitamin C) (Natural Medicines).
  • On file: Cataracts — rated "Possibly Effective" (Vitamin C) (Natural Medicines).
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Grape) (Natural Medicines).

The evidence in our data is mixed and often limited. Vitamin C is effective for preventing vitamin C deficiency and rated possibly effective for a few conditions including anemia of chronic disease, cataracts, and exercise-related respiratory infections.

Vitis Vinifera (grape) is rated possibly effective for chronic venous insufficiency (poor circulation in the legs) but possibly ineffective for hay fever, chemotherapy nausea, and weight loss. Trichopus Zeylanicus has insufficient evidence to rate it for sexual dysfunction, obesity, or peptic ulcers — we simply don't have enough reliable studies.

Arginine Nitrate's effectiveness isn't covered in our data.

The evidence, ingredient by ingredient Vitamin C Grape Trichopus Zeylanicus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal doses, but high doses can trigger abdominal cramps, diarrhea, nausea, heartburn, and headache — effects more likely above 2 grams daily. Kidney stones are a risk in people prone to them.

Grape extract appears well tolerated; common side effects in studies are mild and include abdominal pain, diarrhea, headache, and nausea. Anaphylaxis to grape skin is rare but reported.

Trichopus Zeylanicus is the concern: human safety data are very limited, so use it cautiously and under professional guidance. For pregnancy, normal dietary vitamin C and grapes as food are fine, but avoid high-dose vitamin C supplements and concentrated grape supplements without your doctor's approval.

Trichopus Zeylanicus safety data in pregnancy are absent — avoid it during pregnancy. For breastfeeding, normal vitamin C is okay, but there isn't enough information on concentrated grape supplements or Trichopus Zeylanicus — talk to your pharmacist or doctor.

Side effects, ingredient by ingredient Vitamin C Grape Trichopus Zeylanicus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Grape, Vitamin C, Trichopus Zeylanicus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 1,054 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against these types before using Yok3D: estrogens (birth control, HRT) — Moderate risk; blood thinners and antiplatelet drugs — Moderate risk; chemotherapy drugs including alkylating agents and antitumor antibiotics — Moderate risk; levothyroxine for thyroid disease — Moderate risk; cyclosporine for transplant or immune conditions — Moderate risk; immunosuppressants — Moderate risk; and medications processed through liver enzyme pathways CYP3A4, CYP2D6, CYP2E1, and CYP1A2 — Moderate risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on birth control, hormone therapy, blood thinners, thyroid medication, or immunosuppressants, check your exact drugs with the tool on this page before starting Yok3D. The grape and vitamin C in this product can meaningfully change how some medications work.

Trichopus Zeylanicus has very limited safety research, so discuss it with your pharmacist if you're considering this product long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yok3D, straight from the product label.

Brand USPlabs
Barcode (UPC) 094922040176
Net contents 90 Capsule(s)
Market status Off market
Date entered into DSLD Dec 23, 2011
DSLD ID 3430
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yok3D by USPlabs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
30
UPC/BARCODE
094922040176
IngredientAmount% DV
Vitamin C100 mg167%
Proprietary Blend1350 mg--
Arginine Nitrate0 NP--
Vitis Vinifera L.0 NP--
Trichopus Zeylanicus extract0 NP--

Other ingredients: Gelatin, Calcium Carbonate, Silicon Dioxide, Vegetable Stearate, FD&C Red #40, FD&C Yellow #6, FD&C Blue #1, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, based on published kinetic data, take 3 capsules 90 minutes before a workout on empty stomach or 2-3 hours before a workout with or without food, whichever is more convenient for you. If training within 2 hours of waking, consume 3 capsules upon waking, with or without food. If you weigh 140 pounds or less, begin by taking 2 capsules. Once tolerance has been assessed, you may add 1 additional capsule per workout based upon the following weight chart: Bodyweight <140 lbs / 141-190 lbs / 191-230 lbs / 231 lbs + Dose 2 Capsules / 3 Capsules / 4 Capsules / 4-5 Capsules Take on workout days only. Use in conjunction with proper exercise & nutrition protocol for your desired results. Read more about Yok3d at Getyok3d.com DUE TO EXTREME POTENCY, DO NOT EXCEED 5CAPSULES IN ANY 24 HOUR PERIOD. USE FOR A MAXIMUM OF 12 WEEKS FOLLOWED BY AT LEAST 2 WEEKS OFF.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Pregnant or nursing women should not use this product.

Do not use if safety seal is broken or missing.

WARNING: This product is only intended to be consumed by healthy adults 18 years of age or older. Consult with your health care provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes or any other medication or product. DO NOT USE IF YOU ARE TAKING ERECTILE DYSFUNCTION MEDICATION. DO NOT TAKE ADDITIONAL NITRATES IN THE FORM OF MEDICATION OR DIETARY SUPPLEMENTS ALONG WITH THIS PRODUCT. Do not use antibacterial mouthwash within 4 hours of consuming Yok3d unless otherwise directed by a physician. Discontinue use 2 weeks prior to surgery. Do not combine with alcohol. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving.

FDA Disclaimer Statement

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.

General Statements

(9-5 EST Mon-Fri)

*Based on 3-5 capsules per workout, up to 4 workouts per week.

0-9492204017-6

following Good Manufacturing Practices (GMP)

MONTH + SUPPLY!*

Pharmacologically-Advanced Nitric Oxide Enhancing Breakthrough†

Small Dose. Ridiculous Pump.† Dominant Performance.†

General

L-023-01

Brand IP Statement(s)

Powergrape(R) is a registered trademark of Naturex Inc.

Seals/Symbols

USPlabs(TM) Ultra-Premium Supplements

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yok3D by USPlabs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yok3D label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yok3D by USPlabs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
100 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Proprietary Blend

1350 mg per serving

Other (inactive) ingredients: Gelatin, Calcium Carbonate, Silicon Dioxide, Vegetable Stearate, FD&C Red #40, FD&C Yellow #6, FD&C Blue #1, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yok3D by USPlabs Drug Interactions

Want to check YOUR meds against Yok3D?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,053Drugs
1,005 Moderate 48 Minor

Ingredients driving the most interactions

Vitis Vinifera L. 910
Vitamin C 207
Trichopus Zeylanicus extract 121

Individual Drug Interactions

The ingredients in Yok3D interact with 1,053 drugs. Click any drug to see the details.

3 of the 4 ingredients in Yok3D interact with drugs. Each result below shows which ingredient is responsible. Vitis Vinifera L. Vitamin C Trichopus Zeylanicus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Yok3D with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitis Vinifera L.9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Vitis Vinifera L. full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Trichopus Zeylanicus extract1 drug type · 121 drugs

Immunosuppressants

Theoretically, Trichopus zeylanicus might reduce the effects of immunosuppressants. Animal research suggests that Trichopus zeylanicus might have immunostimulant effects.

Likelihood Possible Evidence D
Trichopus Zeylanicus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yok3D, from the product label.

USPlabs

See all USPlabs products
Web Address
www.usplabsdirect.com
Pharmacist Counseling Corner

Yok3D by USPlabs: Common Questions

Does Yok3D by USPlabs interact with any medications?
Yes. Based on its ingredients, Yok3D has a known interaction with 1,053 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yok3D contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Yok3D with my birth control or hormone replacement therapy?
Not without checking with your pharmacist first. Vitamin C in this product can increase blood estrogen levels significantly — up to 55% in some cases — which might reduce how well your contraception works or change your HRT effects. Talk to your pharmacist about whether this product is safe for you.
What are the most common side effects of Vitamin C in this product?
At normal amounts, Vitamin C is well tolerated. But higher doses can cause abdominal cramps, diarrhea, heartburn, nausea, and headache. These are more likely if you take more than 2 grams daily. If you're prone to kidney stones, higher doses raise that risk too.
Is the grape extract in this product safe for people on blood thinners?
Theoretically, grape extracts may have antiplatelet effects and could increase bleeding risk if you're on blood thinners or antiplatelet drugs. The research isn't certain, but you should definitely tell your pharmacist or doctor about this product if you take those medications.
What is Trichopus Zeylanicus extract, and how safe is it?
It's a plant extract with very limited human safety research. The evidence isn't strong enough to say much about how well it works or how safe it really is. Use it cautiously and only under professional guidance — and avoid it entirely if you're pregnant or breastfeeding.
Is this product okay to use during pregnancy or breastfeeding?
Normal dietary vitamin C and grapes as food are fine, but avoid high-dose vitamin C supplements and concentrated grape supplements without your doctor's okay. Trichopus Zeylanicus is not established as safe — avoid it in pregnancy and don't use concentrated grape supplements while breastfeeding without talking to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yok3D label
Go deeper

The Full Monographs Behind Yok3D’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Trichopus Zeylanicus

Interacts with 121 drugs

Trichopus zeylanicus is a tropical herb traditionally used as a tonic to boost energy and resist stress, but human evidence is very limited and mostly based on animal or laboratory studies....

Read the full Trichopus Zeylanicus monograph →
Sources

Sources & How We Checked

Yok3D's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
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Grape 34 references
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See these in context on the Grape monograph →

Trichopus Zeylanicus 1 reference
  1. Singh B, Chandan BK, Sharma N, et al. Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II). Phytomedicine 2005;12:468-81. PubMed

See these in context on the Trichopus Zeylanicus monograph →

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