Fluconazole

Major

Fluconazole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Fluconazole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Fluconazole Midazolam Nasal Spray Nayzilam Increased midazolam exposure and potential midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Fluconazole Midazolam Injection Nayzilam Increased midazolam exposure and potential midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Fluconazole Midostaurin Rydapt Increased sensitive CYP3A4 substrates exposure Details Fluconazole Mitapivat Aqvesme Increased mitapivat exposure Details Fluconazole Moxifloxacin Avelox Increased risk of QT interval prolongation Details Fluconazole Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Fluconazole Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Fluconazole Naloxegol Movantik Increased naloxegol exposure Details Fluconazole Neratinib Nerlynx Increased sensitive CYP3A4 substrates exposure Details Fluconazole Nevirapine Viramune Increased nevirapine exposure and an increased risk of nevirapine-related adverse events Details Fluconazole Nifedipine Adalat® Increased NIFEdipine exposure Details Fluconazole Nisoldipine Sular Increased nisoldipine exposure and an increased risk for nisoldipine toxicity Details Fluconazole Nitrofurantoin Furadantin Increased risk of hepatic and pulmonary toxicity Details Fluconazole Octreotide Bynfezia An increased risk of QT interval prolongation Details Fluconazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Fluconazole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Fluconazole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Fluconazole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Fluconazole Olaparib Lynparza Increased olaparib exposure Details Fluconazole Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Fluconazole Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Fluconazole Ospemifene Osphena Increased ospemifene exposure Details

Moderate

Fluconazole Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Fluconazole Brentuximab Vedotin Injection Adcetris Increased brentuximab vedotin exposure Details Fluconazole Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Fluconazole Cyclophosphamide Cytoxan® Reduced activation of cycloPHOSphamide to 4-hydroxycycloPHOSphamide and a risk of increased serum bilirubin and creatinine Details Fluconazole Cyclophosphamide Injection Cytoxan® Injection Reduced activation of cycloPHOSphamide to 4-hydroxycycloPHOSphamide and a risk of increased serum bilirubin and creatinine Details Fluconazole Dexamethasone Injection Decadron Increased dexAMETHasone exposure Details Fluconazole Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased dexAMETHasone exposure Details Fluconazole Diclofenac Ophthalmic Voltaren® Eye Drops Increased exposure of diclofenac Details Fluconazole Diclofenac Topical (Actinic Keratosis) Pennsaid Increased exposure of diclofenac Details Fluconazole Diclofenac Topical (Arthritis Pain) Pennsaid® Increased exposure of diclofenac Details Fluconazole Diclofenac Transdermal Patch Flector Increased exposure of diclofenac Details Fluconazole Dutasteride Avodart Increased dutasteride exposure and risk for toxicity Details Fluconazole Erlotinib Tarceva Increased erlotinib exposure Details Fluconazole Esomeprazole Nexium Increased esomeprazole plasma concentrations Details Fluconazole Esomeprazole Injection Nexium Increased esomeprazole plasma concentrations Details Fluconazole Guanfacine Intuniv Increased guanfacine exposure Details