Fluconazole

Name: Fluconazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

166 interactions 13 explained in plain English

Also sold as: Diflucan

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Glasdegib Bedaquiline Sertraline Buprenorphine Ketoconazole Topical

16 Contraindicated 128 Major 22 Moderate

All (166) Contraindicated (16) Major (128) Moderate (22)

Moderate

Fluconazole Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Fluconazole Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Fluconazole Losartan Arbli Reduced conversion of losartan to its active metabolite (E-3174) Details Fluconazole Nateglinide Starlix® Increased risk of hypoglycemia Details Fluconazole Nicardipine Cardene Increased niCARdipine serum concentrations and toxicity (dizziness, hypotension, flushing, headache, peripheral edema) Details Fluconazole Nimodipine Nimotop Increased nimodipine serum levels Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.