Flurazepam

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Buprenorphine Esketamine Nasal Spray Nalbuphine Injection Morphine Injection Hydromorphone Rectal
21 Major 1 Moderate
All (22) Major (21) Moderate (1)

Major

Flurazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Flurazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Flurazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Flurazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Flurazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Flurazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Flurazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Flurazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Flurazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Flurazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Flurazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Flurazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Flurazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Flurazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Flurazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Flurazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Flurazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Flurazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Flurazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Flurazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Flurazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Flurazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.