1,3-dmaa + Dicloxacillin Injection
Dicloxacillin Injection brand name: Dynapen Injection.
We found no known interaction between 1,3-dmaa and Dicloxacillin Injection in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dicloxacillin Injection states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
1,3-dmaa and Dicloxacillin Injection
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dicloxacillin Injection and 1,3-dmaa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
1,3-dmaa safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Dicloxacillin Injection
Interactions in our licensed database are recorded against drug classes, not just single drug names. Dicloxacillin Injection is filed under 3 classifications — antibiotic drugs, nephrotoxic drugs, seizure threshold lowering drugs. 1,3-dmaa has documented interactions with 2 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate) and stimulant drugs (moderate) — and none of Dicloxacillin Injection’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
1,3-dmaa Does Interact With Other Medications
1,3-dmaa has 321 moderate known drug interactions in our database — Dicloxacillin Injection isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 1,3-dmaa
We haven’t checked that one against 1,3-dmaa yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 1,3-dmaa. Pick one to open its full report.
Some Dicloxacillin Injection Products Have a Food Rule — 1,3-dmaa Should Not Break It
At least one FDA label for a product containing Dicloxacillin Injection says to take it on an empty stomach. Most supplements — 1,3-dmaa included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Dicloxacillin Injection on its own and move 1,3-dmaa to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dicloxacillin Injection products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Patients weighing less than 40 kg (88 lbs) DRUG ADULTS CHILDREN Mild to Moderate Severe Mild to Moderate Severe Dicloxacillin 125 mg every 6 hours 250 mg every 6 hours 12.5 mg/kg/day 1 in equally divided doses every 6 hours 25 mg/kg/day 1 in equally divided doses every 6 hours Dicloxacillin is best absorbed when taken on an empty stomach, and should be administered at least 1 hour before or 2 hour
From the Dosage and Administration section of the FDA label we read for Dicloxacillin Injection — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Dicloxacillin Injection
This page covers 1,3-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dicloxacillin Injection page lists 39 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).
By severity: 2 major · 35 moderate · 2 minor.
From our pharmacist’s overview on the Dicloxacillin Injection page
“Dicloxacillin Injection (Dynapen) is a penicillin antibiotic used against serious bacterial infections, and this list earns real caution, chiefly for its two major-rated entries. Siberian cocklebur and asarabacca can each damage the kidneys, and pairing them with other kidney-stressing substances risks compounding that harm, so I would…”
Reviewed by 2 · Jul 18, 2026
Taking 1,3-dmaa as Part of a Dietary Supplement Product? Check It for Interactions
We hold 94 real supplement products containing 1,3-dmaa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1,3-dmaa. Even though 1,3-dmaa itself has no known interaction with Dicloxacillin Injection, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 1,3-dmaa and Dicloxacillin Injection Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#414 of 1,452 supplements looked up here in the last 7 days
#1,675 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,3-dmaa reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1,3-dmaa and Dicloxacillin Injection records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 1,3-dmaa
What is 1,3-dmaa?
- Energy and stimulation
- Pre-workout performance
- Weight loss
- Appetite suppression
- Focus and concentration
DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart problems, strokes, and deaths. The U.S. FDA and regulators in many countries have declared it illegal and unsafe in dietary supplements, so it should be avoided.
Synthetic compound (not a true plant part); sometimes claimed to come from geranium · Capsules, tablets, pre-workout powders (often as a hidden ingredient)
An interaction check asks whether these two react with each other — it does not ask whether 1,3-dmaa is a good idea for someone in your situation. Here is what our 1,3-dmaa record says about it on its own.
1,3-dmaa: dosing
There is no safe or established dose of DMAA. It is not approved as a dietary supplement ingredient, and we do not recommend taking it in any amount.Because DMAA may be hidden in some products, the safest approach is to avoid pre-workout or weight-loss supplements that list ingredients like dimethylamylamine, methylhexanamine, or Geranamine.
From our 1,3-dmaa monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & 1,3-dmaa
Browse every other medication we’ve checked against 1,3-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
321 interactions
- Phentermine ›
- Methylphenidate ›
- Propranolol ›
- Lidocaine ›
- Phenylpropanolamine ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Dextromethorphan ›
- Formoterol ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Diethylpropion ›
- Lofepramine ›
- Nortriptyline ›
- Propoxyphene ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Fluphenazine ›
- Modafinil ›
- Oxymetazoline Hydrochloride ›
- Paroxetine ›
- Timolol ›
- Tramadol ›
- Vortioxetine ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
- Caffeine (prescription Drug) ›
- Carvedilol ›
- Chlorpromazine ›
- Chlorpropamide ›
- Clomipramine ›
- Clozapine ›
- Cocaine Hydrochloride (prescription Drug) ›
- Desvenlafaxine ›
- Ephedrine Sulfate ›
- Fluoxetine ›
- Galantamine ›
- Hydrocodone ›
- Hydrocodone Bitartrate ›
- Imipramine ›
- Meperidine ›
- Methylphenidate Hydrochloride ›
- Metoprolol ›
- Nebivolol ›
- Oxycodone Hydrochloride ›
- Pemoline ›
- Pindolol ›
- Propafenone ›
- Pseudoephedrine Sulfate ›
- Quetiapine ›
- Risperidone ›
- Tamoxifen Citrate ›
- Tolterodine ›
Showing 60 of 321 moderate interactions — see all 321 on the 1,3-dmaa page.
No interaction 2,508 drugs checked — show the list
We also checked 1,3-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
Showing the 60 most looked-up of 2,508 medications checked with no known interaction — see the full 1,3-dmaa list.
1,3-dmaa References
The 21 references that drive our 1,3-dmaa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
- Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
- Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).
- McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
- McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
- Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
- Young C, Oladipo O, Frasier S, et al. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Mil Med 2012;177(12):1450-4. PubMed
- Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
- Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
- Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
- Bloomer RJ, Farney TM, Harvey IC, Alleman RJ. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. 2013 Nov;32(11):1126-36. PubMed
- Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
- Dolan SB, Gatch MB. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015 Jan 1;146:97-102. PubMed
- Dunn M. Have prohibition policies made the wrong decision? A critical review of studies investigating the effects of DMAA. Int J Drug Policy. 2017 Feb;40:26-34. PubMed
- Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. PubMed
- Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
- Palmer PG Jr. Deadly dimethylamylamine: "health" supplements are killing consumers while current regulations impede FDA action. J Leg Med. 2014;35(2):311-36. PubMed
- Schilling BK, Hammond KG, Bloomer RJ, Presley CS, Yates CR. Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men. BMC Pharmacol Toxicol. 2013 Oct 4;14:52. PubMed
- Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed
- Whitehead PN, Schilling BK, Farney TM, Bloomer RJ. Impact of a dietary supplement containing 1,3-dimethylamylamine on blood pressure and bloodborne markers of health: a 10-week intervention study. Nutr Metab Insights. 2012 Feb 2;5:33-9. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Dicloxacillin Injection Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Dicloxacillin Injection as a medicine that can lower these. This is not an interaction with 1,3-dmaa — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Dicloxacillin Injection nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 1,3-dmaa and Dicloxacillin Injection Together: Common Questions
Is it safe to take 1,3-dmaa with Dicloxacillin Injection?
Do 1,3-dmaa and Dicloxacillin Injection have any of the same side effects?
Should I take 1,3-dmaa and Dicloxacillin Injection at the same time of day?
How was the 1,3-dmaa and Dicloxacillin Injection combination checked?
Does 1,3-dmaa interact with any other medications?
Does Dicloxacillin Injection interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.