Drug & supplement interaction

Burdock + Eltrombopag

Eltrombopag brand names: Promacta, Revolade, Alvaiz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Burdock and Eltrombopag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Eltrombopag states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Burdock and Eltrombopag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Eltrombopag and Burdock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burdock safety at a glance

Burdock overall Use caution Likely safe as a food and for short-term use in healthy adults, but human safety data are limited.
Pregnancy Avoid Avoid medicinal amounts during pregnancy due to lack of safety data and possible effects on the uterus.
Breastfeeding Avoid Not enough safety information, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

While burdock root has been traditionally used in herbal medicine for a variety of health conditions, its potential interactions with medications have not been well studied. Currently, there is only limited information available.

Burdock contains a variety of different compounds, includin arctigenin, arctiin, beta-eudesmol, caffeic acid, chlorogenic acid, diarctigenin, inulin, lappaol, tannin, trachelogenin, and sitosterol-beta-D-glucopyranoside, all of which can have a wide range of effects.

One of the only theoretical interactions that have been suggested is with anticoagulant and antiplatelet medications, as burdock root may have mild blood-thinning effects. This has only been seen in animal studies, however.

Further research is needed to fully understand the potential interactions between burdock root and medications.

—

Still wondering about combining Eltrombopag and Burdock? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Eltrombopag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Eltrombopag is filed under 2 classifications — hepatotoxic drugs, oral drugs. Burdock has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Eltrombopag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Burdock Does Interact With Other Medications

Burdock has 122 moderate known drug interactions in our database — Eltrombopag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Eltrombopag)
Taking anything else?

Check Another of Your Medications Against Burdock

Covers the 2,830 medications we’ve checked against Burdock. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Burdock and Eltrombopag May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • A low platelet count / Bleeding or bruising Worth acting on Additional detail

    Burdock

    “In one case report, a 38-year-old female developed immune-mediated thrombocytopenia after consuming a "cleansing" tea containing unknown amounts of burdock and yellow dock. The patient presented with bruising, mild weakness, and fatigue, which started 2-3 days after consuming the tea, and was found to have a platelet count of 5,000 per mcL.”

    Burdock · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 108971. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Burdock

    “A case of idiosyncratic drug-induced liver disease (DILI) is reported in a 36-year-old female who presented with abdominal pain after 1 month of taking an herbal liver detox tea containing burdock and other ingredients. Remarkable laboratory values included elevated liver enzymes, alkaline phosphatase, and total bilirubin. The patient received a loading dose of N-acetylcysteine and was hospitalized for 12 days.”

    Burdock · Natural Medicines adverse-effect record, reported in cirrhosis.

    1 source cited
    1. 112178. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

  • Dry mouth / Dizziness Additional detail

    Burdock

    “Anticholinergic reactions including dry mouth, dizziness, blurred vision, weakness, dilated pupils, inability to urinate, and bradycardia have been reported following the consumption of burdock products. However, these anticholinergic reactions are believed result from contamination of burdock with belladonna alkaloids.”

    Burdock · Natural Medicines adverse-effect record, reported in dry mouth.

    5 sources cited
    1. 12662. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
    2. 37421. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
    3. 37431. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
    4. 37434. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
    5. 37435. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

  • Stomach pain Additional detail

    Burdock

    Recorded for Burdock in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

  • Tiredness Additional detail

    Burdock

    Recorded for Burdock in the same Natural Medicines adverse-effect record shown under A low platelet count / Bleeding or bruising above.

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

  • A skin rash Additional detail

    Burdock

    “Orally, burdock is well tolerated when consumed as a food. Although a thorough evaluation of safety outcomes is lacking, there has been long-standing historical use of burdock with few noted adverse effects.

    Serious Adverse Effects (Rare):

    All ROAs: Allergic reactions, including contact dermatitis and anaphylaxis.”

    Burdock · Natural Medicines adverse-effect record, reported in dermatitis.

    “Contact dermatitis has been reported secondary to burdock, especially after prolonged use of the root oil. There are cases of allergic dermatitis secondary to using burdock plasters. Two males and a 14 year-old female developed erythematous and vesicular, pruritic, and exudative reactions in areas corresponding to the application of burdock root plasters. Reactions occurred up to 7 days after initial use.”

    Burdock · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 37422. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
    2. 12667. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.

    Eltrombopag

    Listed in the ADVERSE REACTIONS section of the FDA label for Eltrombopag. Read the label on DailyMed ›

Reported for Burdock but not commonly for Eltrombopag: trouble passing urine, low blood pressure, an allergic reaction and a severe allergic reaction.

Effects for Eltrombopag come from the ADVERSE REACTIONS section of its FDA label; effects for Burdock come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Eltrombopag Products Have a Food Rule — Burdock Should Not Break It

At least one FDA label for a product containing Eltrombopag says to take it with food. If you take Burdock on an empty stomach out of habit, keep them separate — and take Eltrombopag with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Eltrombopag products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Do not split, chew, or crush tablets and mix with food or liquids.

From the Dosage and Administration section of the FDA label we read for Eltrombopag — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Eltrombopag Is Prescribed For, and What Burdock Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Eltrombopag is a prescription medicine with approved uses on its FDA label. Burdock is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Eltrombopag is prescribed for: Eltrombopag treats thrombocytopenia (low platelet counts) in several different conditions. It is used for adults and children (age 1 and older, depending on the product) with persistent or chronic immune thrombocytopenia (ITP) — a condition where the immune system destroys platelets — when other treatments like steroids or immunoglobulins haven't worked well enough. It is also used to raise platelet counts in adults with chronic hepatitis C whose low platelet count prevents them from starting or staying on interferon-based antiviral therapy. Eltrombopag tablets (including Promacta) are also approved — alone or combined with immunosuppressive therapy — for adults and certain children (age 2 and older) with severe aplastic anemia, a serious bone marrow failure condition.

Read the rest of what Eltrombopag is prescribed for

Alvaiz (a specific brand) shares most of these uses but has product-specific dosing that is not interchangeable milligram-for-milligram with other eltrombopag products. The oral suspension formulation is approved for ITP and for refractory severe aplastic anemia, but is not approved for first-line severe aplastic anemia in combination with immunosuppressive therapy.

Burdock has been studied for:

  • Hepatitis studied, not established Burdock has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Burdock for hepatitis

    Although there is interest in using oral burdock for hepatitis, there is insufficient reliable information about the clinical effects of burdock for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Eltrombopag on your own; if you are taking Burdock for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Burdock or Eltrombopag

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Burdock or Eltrombopag, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Eltrombopag

This page covers Burdock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Eltrombopag page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 42 moderate · 9 minor.

From our pharmacist’s overview on the Eltrombopag page

“Eltrombopag (Promacta, Revolade) boosts platelet production, and because the drug itself can stress the liver, this list warrants genuine care. Thirty-eight of the 55 supplements and herbs here can injure the liver on their own, so combining them stacks risk on an organ your doctor is already watching with blood tests.”

Reviewed by 2 · Jul 18, 2026

Open the Eltrombopag interaction page

One more smart check

Taking Burdock as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,982 real supplement products containing Burdock, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Burdock. Even though Burdock itself has no known interaction with Eltrombopag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Burdock and Eltrombopag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burdock
Top 10%

#136 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Eltrombopag
Steady interest

#2,154 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Burdock reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Burdock and Eltrombopag records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burdock

What is Burdock?

Burdock
  • Skin conditions like acne and eczema
  • Digestive support
  • Diuretic ('detox') and blood purifier
  • Sore throat and cold symptoms
  • Antioxidant support

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is widely eaten as a vegetable and is generally considered low-risk for short-term use in healthy adults, but it should be avoided during pregnancy and breastfeeding and by people allergic to ragweed or daisy-family plants.

Arctium lappa · Asteraceae · Root, leaves, and seeds (fruit) · Tea, dried root, capsules, tinctures, liquid extracts, and fresh root used as food

An interaction check asks whether these two react with each other — it does not ask whether Burdock is a good idea for someone in your situation. Here is what our Burdock record says about it on its own.

Burdock: dosing

There is no well-established standard dose of burdock for any medical condition. Amounts vary widely depending on whether you use the fresh root, dried root tea, a tincture, or a capsule.The best approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Burdock monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burdock monograph & all interactions
Medication

About Eltrombopag

What Is Eltrombopag Used For?

Brand names: Promacta, Revolade, Alvaiz

Eltrombopag treats thrombocytopenia (low platelet counts) in several different conditions. It is used for adults and children (age 1 and older, depending on the product) with persistent or chronic immune thrombocytopenia (ITP) — a condition where the immune system destroys platelets — when other treatments like steroids or immunoglobulins haven't worked well enough. It is also used to raise platelet counts in adults with chronic hepatitis C whose low platelet count prevents them from starting or staying on interferon-based antiviral therapy.

Eltrombopag tablets (including Promacta) are also approved — alone or combined with immunosuppressive therapy — for adults and certain children (age 2 and older) with severe aplastic anemia, a serious bone marrow failure condition. Alvaiz (a specific brand) shares most of these uses but has product-specific dosing that is not interchangeable milligram-for-milligram with other eltrombopag products. The oral suspension formulation is approved for ITP and for refractory severe aplastic anemia, but is not approved for first-line severe aplastic anemia in combination with immunosuppressive therapy.

See full Eltrombopag drug information
Keep checking

Other Drugs & Burdock

Browse every other medication we’ve checked against Burdock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Burdock page.

No interaction 2,707 drugs checked — show the list

We also checked Burdock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Burdock list.

See the full Burdock interactions page
See every supplement checked against Eltrombopag, ranked by severity
Evidence & sources

Burdock References

The 11 references that drive our Burdock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Burdock and Eltrombopag Together: Common Questions

Is it safe to take Burdock with Eltrombopag?
We do not list a known interaction between Burdock and Eltrombopag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Burdock and Eltrombopag have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Burdock and Eltrombopag at the same time of day?
At least one FDA label for a product containing Eltrombopag says to take it with food. If you take Burdock on an empty stomach out of habit, keep them separate and take Eltrombopag with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Eltrombopag products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Burdock and Eltrombopag used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Burdock in each. That is a conversation for your prescriber, especially if Eltrombopag is being adjusted to a target.
How was the Burdock and Eltrombopag combination checked?
Interactions in our licensed database are recorded against drug classes. Eltrombopag is filed under 2 classifications, and Burdock has documented interactions with 1 drug class — none of Eltrombopag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Burdock interact with any other medications?
Yes. Burdock has 122 documented drug interactions in our database — Eltrombopag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Eltrombopag interact with any supplements?
Yes. Eltrombopag has documented interactions with 55 supplements in our database — Burdock is not one of them. The Eltrombopag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Burdock monograph Uses, safety profile, and every drug interaction in one place Eltrombopag drug information The full plain-English guide to this medication Eltrombopag supplement interactions Every supplement checked against Eltrombopag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Eltrombopag and Burdock?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.