Drug & supplement interaction

Calotropis + Levonorgestrel

Levonorgestrel brand names: Plan B, Mirena, Levonelle One Step, Levonelle 1500, Norgeston, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Calotropis and Levonorgestrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Calotropis and Levonorgestrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levonorgestrel and Calotropis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calotropis safety at a glance

Calotropis overall Avoid The plant contains toxic cardiac glycosides and an irritant latex that can cause serious harm if swallowed or rubbed in the eyes.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levonorgestrel and Calotropis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levonorgestrel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levonorgestrel is filed under 6 classifications — including contraceptive drugs, cytochrome p450 1a2 (cyp1a2) inhibitors, topical drugs. Calotropis has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (moderate), diuretic drugs (moderate) and lithium (moderate) — and none of Levonorgestrel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calotropis Does Interact With Other Medications

Calotropis has 98 moderate known drug interactions in our database — Levonorgestrel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 98 No known interaction 2,732 (incl. Levonorgestrel)
Taking anything else?

Check Another of Your Medications Against Calotropis

Covers the 2,830 medications we’ve checked against Calotropis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Calotropis and Levonorgestrel May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Calotropis

    “Topically, calotropis has been reported to cause allergic contact dermatitis. In one case report, a 24-year-old male developed allergic dermatitis of the penis and scrotum after touching a calotropis plant with his hands and then spreading exposure to the penis and scrotum. The patient experienced redness, burning, lesions, and a watery discharge.”

    Calotropis · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 95217. Handa F, Sadana JK, Sharma PK. Allergic contact dermatitis due to the plant Calotropis procera (Vern: AK). A case report. Indian J Dermatol. 1984 Jul;29(3):27-9.

    “Topically, calotropis has been reported to cause allergic contact dermatitis.”

    Calotropis · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 95217. Handa F, Sadana JK, Sharma PK. Allergic contact dermatitis due to the plant Calotropis procera (Vern: AK). A case report. Indian J Dermatol. 1984 Jul;29(3):27-9.

    Levonorgestrel

    Listed in the ADVERSE REACTIONS section of the FDA label for Levonorgestrel. Read the label on DailyMed ›

Reported for Calotropis but not commonly for Levonorgestrel: seizures, a slow heartbeat, loss of vision and vomiting.

Effects for Levonorgestrel come from the ADVERSE REACTIONS section of its FDA label; effects for Calotropis come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 206,325 voluntary FDA FAERS reports for Levonorgestrel that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Calotropis in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Calotropis or Levonorgestrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calotropis or Levonorgestrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levonorgestrel

This page covers Calotropis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levonorgestrel page lists 191 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 142 moderate · 43 minor.

From our pharmacist’s overview on the Levonorgestrel page

“St. John's wort tops my worry list for anyone using levonorgestrel (Plan B, Mirena, and other birth control).”

Reviewed by 2 · Jul 18, 2026

Open the Levonorgestrel interaction page

How much people look this up

Where Calotropis and Levonorgestrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calotropis
Steady interest

#1,166 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levonorgestrel
Top half

#761 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calotropis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Calotropis and Levonorgestrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calotropis

What is Calotropis?

  • Skin conditions and wounds (traditional, topical)
  • Joint pain and inflammation
  • Digestive complaints
  • Coughs and respiratory issues
  • Traditional Ayurvedic and folk remedies

Calotropis is a milkweed-family plant long used in traditional medicine, but its milky latex and other parts are potentially toxic and can harm the eyes, skin, and heart. Human evidence for any health benefit is very limited, and the risk of poisoning is real, so it should not be taken internally without expert medical supervision.

Calotropis procera · Apocynaceae · Latex (milky sap), leaves, roots, and flowers · Traditional preparations such as dried plant powder, root or leaf extracts, and topical applications of latex; rarely standardized commercial products

An interaction check asks whether these two react with each other — it does not ask whether Calotropis is a good idea for someone in your situation. Here is what our Calotropis record says about it on its own.

Calotropis: dosing

There is no established safe or standardized dose of Calotropis. In general, internal use is best avoided.

From our Calotropis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calotropis monograph & all interactions
Medication

About Levonorgestrel

What Is Levonorgestrel Used For?

Brand names: Plan B, Mirena, Levonelle One Step, Levonelle 1500, Norgeston, Skyla, Liletta, Kyleena

Levonorgestrel is used in two very different ways, depending on the product.

The intrauterine systems (Mirena, Liletta, Kyleena and Skyla) prevent pregnancy for a set number of years. Mirena and Liletta are also used to treat heavy menstrual bleeding in women who choose intrauterine contraception. The oral tablets are used for emergency contraception, to reduce the chance of pregnancy after unprotected sex.

Most-Reported Side Effects for Levonorgestrel

From FAERS, the FDA’s public side-effect reporting system (206,325 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Device expulsion 45,536 reports
Device dislocation 20,447 reports
Menstruation irregular 15,061 reports
Vaginal haemorrhage 15,056 reports
Genital haemorrhage 11,164 reports
See full Levonorgestrel drug information
Keep checking

Other Drugs & Calotropis

Browse every other medication we’ve checked against Calotropis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
98Moderate
0Minor
2,731No known interaction
98 Moderate 2,731 No interaction
Moderate

98 interactions

Showing 60 of 98 moderate interactions — see all 98 on the Calotropis page.

No interaction 2,731 drugs checked — show the list

We also checked Calotropis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,731 medications checked with no known interaction — see the full Calotropis list.

See the full Calotropis interactions page
See every supplement checked against Levonorgestrel, ranked by severity
Evidence & sources

Calotropis References

The 7 references that drive our Calotropis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Al-Mezaine HS, Al-Rajhi AA, Al-Assiri A, Wagoner MD. Calotropis procera (ushaar) keratitis. Am J Ophthalmol. 2005 Jan;139(1):199-202. PubMed
  4. Al-Mezaine HS, Al-Amry MA, Al-Assiri A, et al. Corneal endothelial cytotoxicity of the Calotropis procera (ushaar) plant. Cornea. 2008 May;27(4):504-6. PubMed
  5. Basak SK, Bhaumik A, Mohanta A, Singhal P. Ocular toxicity by latex of Calotropis procera (Sodom apple). Indian J Ophthalmol. 2009 May-Jun;57(3):232-4. PubMed
  6. Biedner B, Rothkoff L, Witztum A. Calotropis procera (Sodom apple) latex keratoconjunctivitis. Isr J Med Sci. 1977 Sep;13(9):914-6.
  7. Handa F, Sadana JK, Sharma PK. Allergic contact dermatitis due to the plant Calotropis procera (Vern: AK). A case report. Indian J Dermatol. 1984 Jul;29(3):27-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calotropis and Levonorgestrel Together: Common Questions

Is it safe to take Calotropis with Levonorgestrel?
We do not list a known interaction between Calotropis and Levonorgestrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Calotropis and Levonorgestrel have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Calotropis and Levonorgestrel combination checked?
Interactions in our licensed database are recorded against drug classes. Levonorgestrel is filed under 6 classifications, and Calotropis has documented interactions with 4 drug classes — none of Levonorgestrel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calotropis interact with any other medications?
Yes. Calotropis has 98 documented drug interactions in our database — Levonorgestrel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levonorgestrel interact with any supplements?
Yes. Levonorgestrel has documented interactions with 191 supplements in our database — Calotropis is not one of them. The Levonorgestrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calotropis monograph Uses, safety profile, and every drug interaction in one place Levonorgestrel drug information The full plain-English guide to this medication Levonorgestrel supplement interactions Every supplement checked against Levonorgestrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levonorgestrel and Calotropis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.