Drug & supplement interaction

Chrysin + Aspirin, Ethoheptazine, Meprobamate

Aspirin, Ethoheptazine, Meprobamate brand name: Equagesic.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aspirin, Ethoheptazine, Meprobamate falls into 2 drug categories that Chrysin can interact with; the most serious is rated moderate. Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chrysin and Aspirin, Ethoheptazine, Meprobamate

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Chrysin interacts with whole categories of medication. Aspirin, Ethoheptazine, Meprobamate falls into 2 of those categories, so it can interact with Chrysin in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Aspirin, Ethoheptazine, Meprobamate

Aspirin, Ethoheptazine, Meprobamate falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Chrysin interacts with.

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the piece to keep an eye on with Equagesic: it contains aspirin, which already thins your blood a bit by keeping platelets from clumping together. Chrysin, in test-tube studies, seems to do something similar. So the worry is that pairing them could add up and nudge your bleeding risk a little higher. In real life that might look like easier bruising, nosebleeds, bleeding gums, or a cut that takes longer to stop.

I'll be honest, this is a theoretical concern based on lab work, not strong human evidence, and chrysin is barely absorbed when swallowed. The other ingredients (ethoheptazine and meprobamate) aren't really part of this. Still, before adding chrysin, run it by your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
  3. Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
  4. Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. PubMed
  5. Liu G, Xie W, He AD, et al. Antiplatelet activity of chrysin via inhibiting platelet aIIbß3-mediated signaling pathway. Mol Nutr Food Res 2016;60(9):1984-93.
Minor

GLUCURONIDATED DRUGS

2 of 2

Aspirin, Ethoheptazine, Meprobamate also falls under GLUCURONIDATED DRUGS.

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture with chrysin and Equagesic (the combo of aspirin, ethoheptazine, and meprobamate). This pain-and-anxiety medication isn't a prodrug, so it doesn't need to be switched on by your body to work. The theory on file is that chrysin might speed up an enzyme called UGT1A1, which helps clear certain medications out. If that happened, your body could remove parts of this drug a little faster, which in theory might make the pain relief or the calming effect feel weaker.

I want to be straight with you though: this is based only on test-tube research, the interaction is rated minor and unlikely, and your body barely absorbs chrysin in the first place. So real-world impact is probably tiny. Still, it's worth mentioning to your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  2. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  3. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chrysin Also Interacts With Other Medications

Chrysin has 178 moderate, 179 minor known drug interactions in our database — the Aspirin, Ethoheptazine, Meprobamate one above is among them. If you take anything else, check it against the full list below.

Moderate 178 Minor 179 No known interaction 2,473 (incl. Aspirin, Ethoheptazine, Meprobamate)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Ethoheptazine, Meprobamate

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Ethoheptazine, Meprobamate page lists 304 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 11 major · 260 moderate · 33 minor.

From our pharmacist’s overview on the Aspirin, Ethoheptazine, Meprobamate page

“Equagesic combines aspirin with two sedating pain relievers, ethoheptazine and meprobamate, which means supplements can go wrong in two directions at once, and this list earns genuine care before you mix in any of them. Most of the entries add to aspirin's blood-thinning effect and raise bleeding risk, while a large second group deepen…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Ethoheptazine, Meprobamate interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Your product may carry other ingredients that interact with Aspirin, Ethoheptazine, Meprobamate too, on top of Chrysin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Aspirin, Ethoheptazine, Meprobamate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top 25%

#289 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Ethoheptazine, Meprobamate
Top 5%

#137 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Read the full Chrysin monograph & all interactions
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
178Moderate
179Minor
2,472No known interaction
178 Moderate 179 Minor 2,472 No interaction
Moderate

178 interactions

Showing 60 of 178 moderate interactions — see all 178 on the Chrysin page.

Minor

179 interactions

Showing 60 of 179 minor interactions — see all 179 on the Chrysin page.

No interaction 2,472 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,472 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Aspirin, Ethoheptazine, Meprobamate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chrysin monograph › Uses, safety, and every drug interaction in one place Aspirin, Ethoheptazine, Meprobamate supplement interactions › Every supplement checked against Aspirin, Ethoheptazine, Meprobamate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chrysin and Aspirin, Ethoheptazine, Meprobamate Together: Common Questions

Can you take Chrysin with Aspirin, Ethoheptazine, Meprobamate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Chrysin and Aspirin, Ethoheptazine, Meprobamate?
Aspirin, Ethoheptazine, Meprobamate belongs to more than one drug category, and Chrysin interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Chrysin and Aspirin, Ethoheptazine, Meprobamate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.