Drug & supplement interaction

Chrysin + Ibuprofen, Acetaminophen

Ibuprofen, Acetaminophen brand name: Advil Dual Action.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ibuprofen, Acetaminophen falls into 3 drug categories that Chrysin can interact with; the most serious is rated moderate. Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chrysin and Ibuprofen, Acetaminophen

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Chrysin interacts with whole categories of medication. Ibuprofen, Acetaminophen falls into 3 of those categories, so it can interact with Chrysin in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 3

Why this applies to Ibuprofen, Acetaminophen

Ibuprofen, Acetaminophen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Chrysin interacts with.

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Advil Dual Action: it pairs ibuprofen (an NSAID) with acetaminophen. Ibuprofen on its own can already make it harder for your blood to clot and can irritate the stomach lining, so bleeding risk is the piece that matters here.

In test-tube studies, chrysin appears to slow down platelets (the cells that help your blood clump and stop bleeding). Stacked on top of ibuprofen, the theoretical concern is a little more bruising, nosebleeds, or stomach bleeding. I want to be honest though: this is based on lab work, not real patients, and chrysin is barely absorbed by the body, so the actual risk is probably low. Still, if you're on this combo regularly or notice unusual bruising or dark stools, check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
  3. Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
  4. Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. PubMed
  5. Liu G, Xie W, He AD, et al. Antiplatelet activity of chrysin via inhibiting platelet aIIbß3-mediated signaling pathway. Mol Nutr Food Res 2016;60(9):1984-93.
Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

2 of 3

Ibuprofen, Acetaminophen also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: the worry on paper is that chrysin can slow down a liver enzyme called CYP1A2. If that enzyme handled a big share of clearing this combo product, the medicine could build up and lead to more of the usual stuff, like stomach upset or, with higher ibuprofen levels, irritation of the gut or kidney strain. But that's not really how it plays out here.

The reality is reassuring. Both ibuprofen and acetaminophen rely mostly on other pathways, not CYP1A2, so this enzyme isn't a major route for either one. On top of that, your body absorbs very little chrysin and clears it fast, so it rarely reaches levels that matter. This flag comes only from test-tube work. Still, if you take this product often, it's worth a quick chat with your pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
  3. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  4. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
  5. Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
  6. Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
  7. Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. PubMed
  8. Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121 PubMed
  9. Moon, Y. J., Wang, X., and Morris, M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 2006;20(2):187-210. PubMed
  10. Tsyrlov, I. B., Mikhailenko, V. M., and Gelboin, H. V. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim.Biophys Acta 4-13-1994;1205(2):325-335. PubMed
  11. Noh K, Oh do G, Nepal MR, et al. Pharmacokinetic interaction of chrysin with caffeine in rats. Biomol Ther (Seoul) 2016;24(4):446-52. PubMed
Minor

GLUCURONIDATED DRUGS

3 of 3

Ibuprofen, Acetaminophen also falls under GLUCURONIDATED DRUGS.

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Advil Dual Action, which combines ibuprofen and acetaminophen. In test-tube studies, chrysin appears to speed up a liver pathway called UGT1A1, which helps your body clear out certain medications. Acetaminophen is partly cleared this way, so in theory chrysin could nudge it out of your system a little faster and make it slightly less effective for pain or fever. Neither of these is a prodrug, so this would mean a touch less benefit, not more side effects.

Honestly though, this is a very weak, theoretical concern. It comes from lab work, not real people, and chrysin is poorly absorbed to begin with. I wouldn't lose sleep over it, but if you take chrysin regularly, mention it to your pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  2. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  3. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chrysin Also Interacts With Other Medications

Chrysin has 178 moderate, 179 minor known drug interactions in our database — the Ibuprofen, Acetaminophen one above is among them. If you take anything else, check it against the full list below.

Moderate 178 Minor 179 No known interaction 2,473 (incl. Ibuprofen, Acetaminophen)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Acetaminophen

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Acetaminophen page lists 342 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 290 moderate · 45 minor.

From our pharmacist’s overview on the Ibuprofen, Acetaminophen page

“Advil Dual Action pairs ibuprofen, an NSAID with built-in stomach-bleeding risk, and acetaminophen, which the liver processes, so this interaction list deserves a careful read, not a skim. Most of the entries can add to bleeding risk, while smaller clusters put extra strain on the liver or kidneys.”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen, Acetaminophen interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Your product may carry other ingredients that interact with Ibuprofen, Acetaminophen too, on top of Chrysin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Ibuprofen, Acetaminophen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top 25%

#306 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Acetaminophen
Top 25%

#420 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Read the full Chrysin monograph & all interactions
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
178Moderate
179Minor
2,472No known interaction
178 Moderate 179 Minor 2,472 No interaction
Moderate

178 interactions

Showing 60 of 178 moderate interactions — see all 178 on the Chrysin page.

Minor

179 interactions

Showing 60 of 179 minor interactions — see all 179 on the Chrysin page.

No interaction 2,472 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,472 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Ibuprofen, Acetaminophen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chrysin monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Acetaminophen supplement interactions › Every supplement checked against Ibuprofen, Acetaminophen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chrysin and Ibuprofen, Acetaminophen Together: Common Questions

Can you take Chrysin with Ibuprofen, Acetaminophen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Chrysin and Ibuprofen, Acetaminophen?
Ibuprofen, Acetaminophen belongs to more than one drug category, and Chrysin interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Chrysin and Ibuprofen, Acetaminophen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.