Drug & supplement interaction

Corn Silk + Hydrochlorothiazide, Quinapril

Hydrochlorothiazide, Quinapril brand name: Accuretic.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Hydrochlorothiazide, Quinapril falls into 2 drug categories that Corn Silk can interact with; the most serious is rated moderate. Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Corn Silk and Hydrochlorothiazide, Quinapril

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Corn Silk interacts with whole categories of medication. Hydrochlorothiazide, Quinapril falls into 2 of those categories, so it can interact with Corn Silk in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Hydrochlorothiazide, Quinapril

Hydrochlorothiazide, Quinapril falls under ANTIHYPERTENSIVE DRUGS — the group Corn Silk interacts with.

Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.
Clinical research in both hypertensive and normotensive adults shows that taking corn silk extract lowers systolic and diastolic blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Accuretic combines two blood pressure medicines: hydrochlorothiazide (a water pill) and quinapril (an ACE inhibitor). Both already work to bring your numbers down. The concern here is simple addition. Corn silk has shown a mild blood-pressure-lowering effect of its own in some human studies, so stacking it on top of Accuretic could push your pressure lower than intended.

If that happens, you might feel dizzy or lightheaded, especially when standing up quickly, along with tiredness or a brief faint feeling. This is a theoretical concern based on how things work, not a heavily proven danger, and an occasional cup of corn silk tea is less likely to matter than concentrated extracts. Still, please check with your pharmacist or doctor before adding it, and don't change your Accuretic on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
Moderate

DIURETIC DRUGS

2 of 2

Hydrochlorothiazide, Quinapril also falls under DIURETIC DRUGS.

Taking corn silk with diuretic drugs might increase the risk of adverse effects such as hyponatremia and hypokalemia.
Clinical research shows that taking corn silk extract increases urine volume and promotes the urinary excretion of sodium and potassium. Some patients may require electrolyte supplementation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Accuretic combines two blood pressure medicines: hydrochlorothiazide (a water pill) and quinapril (an ACE inhibitor). The water pill already pulls extra fluid and salt out through your urine, and it tends to lower potassium and sodium. Corn silk seems to act as a mild natural diuretic too, so taking them together could nudge you to lose a bit more sodium and potassium than the medicine alone.

In real life, that might show up as dizziness, fatigue, muscle cramps, or feeling lightheaded when you stand up. Keep in mind this concern is mostly theoretical and based on how corn silk behaves, not strong human studies. An occasional cup of tea is unlikely to cause trouble, but before using concentrated corn silk supplements, please check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Corn Silk Also Interacts With Other Medications

Corn Silk has 289 moderate known drug interactions in our database — the Hydrochlorothiazide, Quinapril one above is among them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Hydrochlorothiazide, Quinapril)
Taking anything else?

Check Another of Your Medications Against Corn Silk

Covers the 2,830 medications we’ve checked against Corn Silk. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Quinapril

This page covers Corn Silk only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Quinapril page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

Open the Hydrochlorothiazide, Quinapril interaction page

One more smart check

Taking Corn Silk as Part of a Dietary Supplement Product? Check It for Interactions

We hold 58 real supplement products containing Corn Silk, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Silk. Your product may carry other ingredients that interact with Hydrochlorothiazide, Quinapril too, on top of Corn Silk — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Silk and Hydrochlorothiazide, Quinapril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Silk
Top half

#510 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Quinapril
Top half

#775 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Corn Silk

What is Corn Silk?

Corn Silk
  • Urinary tract and bladder problems
  • Mild fluid retention (diuretic)
  • Kidney and prostate concerns
  • Bedwetting in children
  • Soothing urinary irritation

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should not replace proven treatments. It is generally considered low-risk for short-term use in healthy adults, but talk with your pharmacist or doctor before trying it.

Read the full Corn Silk monograph & all interactions
Keep checking

Other Drugs & Corn Silk

Browse every other medication we’ve checked against Corn Silk — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
289Moderate
0Minor
2,540No known interaction
289 Moderate 2,540 No interaction
Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Corn Silk page.

No interaction 2,540 drugs checked — show the list

We also checked Corn Silk against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Corn Silk list.

See the full Corn Silk interactions page
See every supplement checked against Hydrochlorothiazide, Quinapril, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Corn Silk monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Quinapril supplement interactions › Every supplement checked against Hydrochlorothiazide, Quinapril, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Corn Silk and Hydrochlorothiazide, Quinapril Together: Common Questions

Can you take Corn Silk with Hydrochlorothiazide, Quinapril?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Corn Silk and Hydrochlorothiazide, Quinapril?
Hydrochlorothiazide, Quinapril belongs to more than one drug category, and Corn Silk interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Corn Silk and Hydrochlorothiazide, Quinapril interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.