Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Quinapril?

Hydrochlorothiazide, Quinapril brand name: Accuretic. Every interaction below applies to the brands too.

236 Interactions 10 Major 199 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Quinapril? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Quinapril against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

236 supplements and herbal ingredients have interactions with Hydrochlorothiazide, Quinapril on file in the HelloPharmacist interaction database — 10 rated major, 199 moderate, and 27 minor. The most serious involve American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 10 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Hydrochlorothiazide, Quinapril.

Major 10 Moderate 199 Minor 27 No known interaction 1,216

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Quinapril: Top Interactions at a Glance

The Hydrochlorothiazide, Quinapril supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 236 interacting ingredients — plus 1,216 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Quinapril Combinations Today

The Hydrochlorothiazide, Quinapril + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Capsicum + Hydrochlorothiazide, Quinaprili

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Read the full interaction Moderate Likelihood Possible Conjugated Linoleic Acid (cla) + Hydrochlorothiazide, Quinaprili

Theoretically, taking CLA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Gamma-aminobutyric Acid (gaba) + Hydrochlorothiazide, Quinaprili

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Theanine + Hydrochlorothiazide, Quinaprili

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Likely American Hellebore + Hydrochlorothiazide, Quinaprili

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydrochlorothiazide, Quinaprili

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Quinapril

All 1,452 ingredients in our database, ranked by severity — 236 with a Hydrochlorothiazide, Quinapril interaction on file and 1,216 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Quinapril?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Capsicum with Hydrochlorothiazide, Quinapril?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Full Capsicum + Hydrochlorothiazide, Quinapril answer

Can you take Conjugated Linoleic Acid (cla) with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CLA with antihypertensive drugs might increase the risk of hypotension.

Full Conjugated Linoleic Acid (cla) + Hydrochlorothiazide, Quinapril answer

Can you take Gamma-aminobutyric Acid (gaba) with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.

Full Gamma-aminobutyric Acid (gaba) + Hydrochlorothiazide, Quinapril answer

Can you take Theanine with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Hydrochlorothiazide, Quinapril answer

Can you take Reishi Mushroom with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Reishi Mushroom + Hydrochlorothiazide, Quinapril answer

Can you take Rhodiola with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Full Rhodiola + Hydrochlorothiazide, Quinapril answer

Can you take Rhubarb with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Hydrochlorothiazide, Quinapril answer

Can you take Rice Protein with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE).

Full Rice Protein + Hydrochlorothiazide, Quinapril answer

Can you take Rooibos with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with ACEIs may increase the therapeutic and adverse effects of ACEIs.

Full Rooibos + Hydrochlorothiazide, Quinapril answer

Can you take Royal Jelly with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Full Royal Jelly + Hydrochlorothiazide, Quinapril answer

Can you take Rue with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Hydrochlorothiazide, Quinapril answer

Can you take Saffron with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Hydrochlorothiazide, Quinapril answer

Can you take Sage with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Hydrochlorothiazide, Quinapril answer

Can you take Sea Buckthorn with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Hydrochlorothiazide, Quinapril answer

Can you take Senna with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Hydrochlorothiazide, Quinapril answer

Can you take Slippery Elm with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Hydrochlorothiazide, Quinapril answer

Can you take Sodium Bicarbonate with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Hydrochlorothiazide, Quinapril answer

Can you take Soy with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Hydrochlorothiazide, Quinapril answer

Can you take Squill with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Hydrochlorothiazide, Quinapril answer

Can you take St. John's Wort with Hydrochlorothiazide, Quinapril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Hydrochlorothiazide, Quinapril answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Quinapril is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Quinapril, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Quinapril sits in 9 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Quinapril through this category.

Related: does Hydrochlorothiazide, Quinapril deplete any nutrients?

Hydrochlorothiazide, Quinapril has 9 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Quinapril nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Quinapril

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Quinapril.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Quinapril & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Quinapril?
Our database currently documents 236 ingredients with a known Hydrochlorothiazide, Quinapril interaction (10 major, 199 moderate, 27 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 236. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Quinapril supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Quinapril?
Plenty of supplements coexist fine with Hydrochlorothiazide, Quinapril; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Accuretic have the same supplement interactions as Hydrochlorothiazide, Quinapril?
Yes — Accuretic all contain Hydrochlorothiazide, Quinapril, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Quinapril deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Quinapril has 9 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Quinapril nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Quinapril and my other medications?
This page covers Hydrochlorothiazide, Quinapril against supplements and herbal ingredients. Checking Hydrochlorothiazide, Quinapril against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.