Drug & supplement interaction

Datura Wrightii + Dextromethorphan HBr, Guaifenesin

Dextromethorphan HBr, Guaifenesin brand names: Vicks Formula 44E Cough & Chest Congestion Relief, Pediatric Vicks Formula 44e Cough & Chest Congesti.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Datura Wrightii and Dextromethorphan HBr, Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Datura Wrightii and Dextromethorphan HBr, Guaifenesin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan HBr, Guaifenesin and Datura Wrightii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Datura Wrightii safety at a glance

Datura Wrightii overall Avoid All parts are highly toxic and poisonings can be fatal; this plant should not be used as a supplement.
Pregnancy Likely Unsafe When plant parts are used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When plant parts are used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan HBr, Guaifenesin and Datura Wrightii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dextromethorphan HBr, Guaifenesin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextromethorphan HBr, Guaifenesin is filed under 6 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 2d6 (cyp2d6) substrates. Datura Wrightii has documented interactions with 2 drug classes — the most serious being anesthesia (moderate) and anticholinergic drugs (moderate) — and none of Dextromethorphan HBr, Guaifenesin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Datura Wrightii Does Interact With Other Medications

Datura Wrightii has 226 moderate known drug interactions in our database — Dextromethorphan HBr, Guaifenesin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 226 No known interaction 2,604 (incl. Dextromethorphan HBr, Guaifenesin)
Taking anything else?

Check Another of Your Medications Against Datura Wrightii

Covers the 2,830 medications we’ve checked against Datura Wrightii. Pick one to open its full report.

What to actually watch for

What Datura Wrightii Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan HBr, Guaifenesin. It is the side-effect record for Datura Wrightii on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Datura Wrightii, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on Additional detail

    “Orally, Datura wrightii causes visual and auditory hallucinations, panic, respiratory depression, and death.”

    Datura Wrightii · Natural Medicines adverse-effect record, reported in depression.

    3 sources cited
    1. 26202. Adams, JD Jr, Garcia C. Spirit, Mind and Body in Chumash Healing. Evid Based Complement Alternat Med 2005;2(4):459-463. PubMed
    2. 26911. Garcia C, Adams J. Healing with medicinal plants of the west - cultural and scientific basis for their use. La Crescenta, CA: Abedus Press; 2005.
    3. 26933. Adams JD, Garcia C. The advantages of traditional chumash healing. Evid Based Complement Alternat Med 2005;2(1):19-23. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Datura Wrightii — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan HBr, Guaifenesin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan HBr, Guaifenesin.

Special populations

Datura Wrightii in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When plant parts are used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Dextromethorphan HBr, Guaifenesin

This page covers Datura Wrightii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan HBr, Guaifenesin page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 125 moderate · 42 minor.

From our pharmacist’s overview on the Dextromethorphan HBr, Guaifenesin page

“A bad cough tends to hit when supplements are already on the counter, and anyone reaching for Vicks Formula 44E (dextromethorphan HBr and guaifenesin) should treat this list with real care, since 4 of its 171 entries carry a major rating. Two themes dominate.”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan HBr, Guaifenesin interaction page

How much people look this up

Where Datura Wrightii and Dextromethorphan HBr, Guaifenesin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Datura Wrightii
Steady interest

#975 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextromethorphan HBr, Guaifenesin
Top half

#1,394 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Datura Wrightii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Datura Wrightii and Dextromethorphan HBr, Guaifenesin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Datura Wrightii

What is Datura Wrightii?

  • Traditional ritual and ceremonial use
  • Pain relief (traditional/topical)
  • Asthma and breathing complaints (historical)
  • Hallucinogenic/psychoactive effects
  • Skin and wound applications (folk use)

Datura wrightii (sacred datura or jimsonweed relative) is a highly poisonous desert plant that has been used in some traditional and ceremonial settings. It is not a safe dietary supplement — even small amounts can cause severe poisoning, hallucinations, and death. We strongly advise against using it.

Datura wrightii · Solanaceae · Leaves, flowers, seeds, and roots (all parts are toxic) · Traditional ceremonial preparations, topical pastes, smoked plant material (not a standard commercial supplement)

An interaction check asks whether these two react with each other — it does not ask whether Datura Wrightii is a good idea for someone in your situation. Here is what our Datura Wrightii record says about it on its own.

Datura Wrightii: dosing

There is no safe or established dose of Datura wrightii. Because the amount of toxic alkaloids varies enormously between plants and plant parts, there is no way to measure a safe amount at home.We do not provide dosing for this plant because we cannot recommend its use.

From our Datura Wrightii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Datura Wrightii monograph & all interactions
Medication

About Dextromethorphan HBr, Guaifenesin

Most-Reported Side Effects for Dextromethorphan HBr, Guaifenesin

From FAERS, the FDA’s public side-effect reporting system (1,675 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 140 reports
Pneumonia 123 reports
Nausea 120 reports
Cough 119 reports
Fatigue 118 reports
Keep checking

Other Drugs & Datura Wrightii

Browse every other medication we’ve checked against Datura Wrightii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
226Moderate
0Minor
2,603No known interaction
226 Moderate 2,603 No interaction
Moderate

226 interactions

Showing 60 of 226 moderate interactions — see all 226 on the Datura Wrightii page.

No interaction 2,603 drugs checked — show the list

We also checked Datura Wrightii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,603 medications checked with no known interaction — see the full Datura Wrightii list.

See the full Datura Wrightii interactions page
See every supplement checked against Dextromethorphan HBr, Guaifenesin, ranked by severity
Evidence & sources

Datura Wrightii References

The 4 references that drive our Datura Wrightii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Adams, JD Jr, Garcia C. Spirit, Mind and Body in Chumash Healing. Evid Based Complement Alternat Med 2005;2(4):459-463. PubMed
  2. Garcia C, Adams J. Healing with medicinal plants of the west - cultural and scientific basis for their use. La Crescenta, CA: Abedus Press; 2005.
  3. Evans WC, Woolley JG. The alkaloids of Datura meteloides D.C. J Chem Soc Perkin 1. 1965;4936-4939.
  4. Adams JD, Garcia C. The advantages of traditional chumash healing. Evid Based Complement Alternat Med 2005;2(1):19-23. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Datura Wrightii and Dextromethorphan HBr, Guaifenesin Together: Common Questions

Is it safe to take Datura Wrightii with Dextromethorphan HBr, Guaifenesin?
We do not list a known interaction between Datura Wrightii and Dextromethorphan HBr, Guaifenesin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Datura Wrightii and Dextromethorphan HBr, Guaifenesin combination checked?
Interactions in our licensed database are recorded against drug classes. Dextromethorphan HBr, Guaifenesin is filed under 6 classifications, and Datura Wrightii has documented interactions with 2 drug classes — none of Dextromethorphan HBr, Guaifenesin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Datura Wrightii interact with any other medications?
Yes. Datura Wrightii has 226 documented drug interactions in our database — Dextromethorphan HBr, Guaifenesin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dextromethorphan HBr, Guaifenesin interact with any supplements?
Yes. Dextromethorphan HBr, Guaifenesin has documented interactions with 171 supplements in our database — Datura Wrightii is not one of them. The Dextromethorphan HBr, Guaifenesin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Datura Wrightii monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan HBr, Guaifenesin supplement interactions Every supplement checked against Dextromethorphan HBr, Guaifenesin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan HBr, Guaifenesin and Datura Wrightii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.