Drug & supplement interaction

Datura Wrightii + Gabapentin

Gabapentin brand names: Neurontin, Gralise.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Datura Wrightii and Gabapentin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Datura Wrightii and Gabapentin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Gabapentin and Datura Wrightii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Datura Wrightii safety at a glance

Datura Wrightii overall Avoid All parts are highly toxic and poisonings can be fatal; this plant should not be used as a supplement.
Pregnancy Likely Unsafe When plant parts are used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When plant parts are used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Gabapentin and Datura Wrightii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Gabapentin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Gabapentin is filed under 4 classifications — including anticonvulsants, cns depressants, oral drugs. Datura Wrightii has documented interactions with 2 drug classes — the most serious being anesthesia (moderate) and anticholinergic drugs (moderate) — and none of Gabapentin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Datura Wrightii Does Interact With Other Medications

Datura Wrightii has 226 moderate known drug interactions in our database — Gabapentin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 226 No known interaction 2,604 (incl. Gabapentin)
Taking anything else?

Check Another of Your Medications Against Datura Wrightii

Covers the 2,830 medications we’ve checked against Datura Wrightii. Pick one to open its full report.

What to actually watch for

What Datura Wrightii Itself Has Been Linked To

This is not an interaction — nothing below involves Gabapentin. It is the side-effect record for Datura Wrightii on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Datura Wrightii, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on Additional detail

    “Orally, Datura wrightii causes visual and auditory hallucinations, panic, respiratory depression, and death.”

    Datura Wrightii · Natural Medicines adverse-effect record, reported in depression.

    3 sources cited
    1. 26202. Adams, JD Jr, Garcia C. Spirit, Mind and Body in Chumash Healing. Evid Based Complement Alternat Med 2005;2(4):459-463. PubMed
    2. 26911. Garcia C, Adams J. Healing with medicinal plants of the west - cultural and scientific basis for their use. La Crescenta, CA: Abedus Press; 2005.
    3. 26933. Adams JD, Garcia C. The advantages of traditional chumash healing. Evid Based Complement Alternat Med 2005;2(1):19-23. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Datura Wrightii — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Gabapentin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Gabapentin column appears here.

Special populations

Datura Wrightii in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When plant parts are used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Datura Wrightii or Gabapentin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Datura Wrightii or Gabapentin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Gabapentin

This page covers Datura Wrightii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gabapentin page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 82 moderate · 17 minor.

From our pharmacist’s overview on the Gabapentin page

“Gabapentin (Neurontin, Gralise) calms overactive nerves, which means it already slows your nervous system down, and that is exactly what 78 of the 106 supplements on this list also do. So the dominant risk here is sedation stacked on sedation, extra drowsiness at best and dangerously slowed breathing at worst, and with seven entries ra…”

Reviewed by 2 · Jul 18, 2026

Open the Gabapentin interaction page

How much people look this up

Where Datura Wrightii and Gabapentin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Datura Wrightii
Steady interest

#969 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gabapentin
Top 5%

#42 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Datura Wrightii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Datura Wrightii and Gabapentin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Datura Wrightii

What is Datura Wrightii?

  • Traditional ritual and ceremonial use
  • Pain relief (traditional/topical)
  • Asthma and breathing complaints (historical)
  • Hallucinogenic/psychoactive effects
  • Skin and wound applications (folk use)

Datura wrightii (sacred datura or jimsonweed relative) is a highly poisonous desert plant that has been used in some traditional and ceremonial settings. It is not a safe dietary supplement — even small amounts can cause severe poisoning, hallucinations, and death. We strongly advise against using it.

Datura wrightii · Solanaceae · Leaves, flowers, seeds, and roots (all parts are toxic) · Traditional ceremonial preparations, topical pastes, smoked plant material (not a standard commercial supplement)

An interaction check asks whether these two react with each other — it does not ask whether Datura Wrightii is a good idea for someone in your situation. Here is what our Datura Wrightii record says about it on its own.

Datura Wrightii: dosing

There is no safe or established dose of Datura wrightii. Because the amount of toxic alkaloids varies enormously between plants and plant parts, there is no way to measure a safe amount at home.We do not provide dosing for this plant because we cannot recommend its use.

From our Datura Wrightii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Datura Wrightii monograph & all interactions
Medication

About Gabapentin

What Is Gabapentin Used For?

Brand names: Neurontin, Gralise

Gabapentin (brands include Neurontin, Relgaabi, Gabarone, Gralise, and Horizant) is primarily used to manage postherpetic neuralgia (PHN) — the nerve pain that lingers after a shingles outbreak — in adults. Neurontin, Relgaabi, Gabarone, and gabapentin capsules, tablets, and oral solution are also used as add-on therapy for partial onset seizures (a type of epilepsy) in adults and children aged 3 and older.

Horizant (gabapentin enacarbil extended-release tablet) has two specific approvals: treatment of moderate-to-severe primary restless legs syndrome (RLS) in adults, and management of postherpetic neuralgia in adults. Horizant is not recommended for people who need to sleep during the day and stay awake at night. Gralise is approved only for postherpetic neuralgia and cannot be substituted for other gabapentin products due to its different release profile.

Most-Reported Side Effects for Gabapentin

From FAERS, the FDA’s public side-effect reporting system (361,481 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 24,972 reports
Nausea 22,728 reports
Diarrhea 18,114 reports
Headache 17,897 reports
Dizziness 16,238 reports
See full Gabapentin drug information
Keep checking

Other Drugs & Datura Wrightii

Browse every other medication we’ve checked against Datura Wrightii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
226Moderate
0Minor
2,603No known interaction
226 Moderate 2,603 No interaction
Moderate

226 interactions

Showing 60 of 226 moderate interactions — see all 226 on the Datura Wrightii page.

No interaction 2,603 drugs checked — show the list

We also checked Datura Wrightii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,603 medications checked with no known interaction — see the full Datura Wrightii list.

See the full Datura Wrightii interactions page
See every supplement checked against Gabapentin, ranked by severity
Evidence & sources

Datura Wrightii References

The 4 references that drive our Datura Wrightii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Adams, JD Jr, Garcia C. Spirit, Mind and Body in Chumash Healing. Evid Based Complement Alternat Med 2005;2(4):459-463. PubMed
  2. Garcia C, Adams J. Healing with medicinal plants of the west - cultural and scientific basis for their use. La Crescenta, CA: Abedus Press; 2005.
  3. Evans WC, Woolley JG. The alkaloids of Datura meteloides D.C. J Chem Soc Perkin 1. 1965;4936-4939.
  4. Adams JD, Garcia C. The advantages of traditional chumash healing. Evid Based Complement Alternat Med 2005;2(1):19-23. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Datura Wrightii and Gabapentin Together: Common Questions

Is it safe to take Datura Wrightii with Gabapentin?
We do not list a known interaction between Datura Wrightii and Gabapentin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Datura Wrightii and Gabapentin combination checked?
Interactions in our licensed database are recorded against drug classes. Gabapentin is filed under 4 classifications, and Datura Wrightii has documented interactions with 2 drug classes — none of Gabapentin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Datura Wrightii interact with any other medications?
Yes. Datura Wrightii has 226 documented drug interactions in our database — Gabapentin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Gabapentin interact with any supplements?
Yes. Gabapentin has documented interactions with 106 supplements in our database — Datura Wrightii is not one of them. The Gabapentin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Datura Wrightii monograph Uses, safety profile, and every drug interaction in one place Gabapentin drug information The full plain-English guide to this medication Gabapentin supplement interactions Every supplement checked against Gabapentin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Gabapentin and Datura Wrightii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.